4GA6
Crystal structure of AMP phosphorylase C-terminal deletion mutant in complex with substrates
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006196 | biological_process | AMP catabolic process |
| A | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| A | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| A | 0009032 | molecular_function | thymidine phosphorylase activity |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0042301 | molecular_function | phosphate ion binding |
| A | 0046125 | biological_process | pyrimidine deoxyribonucleoside metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006196 | biological_process | AMP catabolic process |
| B | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| B | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| B | 0009032 | molecular_function | thymidine phosphorylase activity |
| B | 0016208 | molecular_function | AMP binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0042301 | molecular_function | phosphate ion binding |
| B | 0046125 | biological_process | pyrimidine deoxyribonucleoside metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE AMP A 601 |
| Chain | Residue |
| A | HIS164 |
| A | THR203 |
| A | ASP256 |
| A | MET261 |
| A | SER264 |
| A | LYS288 |
| A | SO4602 |
| A | HOH839 |
| A | SER165 |
| A | ILE166 |
| A | GLY168 |
| A | SER194 |
| A | ALA196 |
| A | ILE197 |
| A | THR198 |
| A | SER199 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | HIS164 |
| A | SER165 |
| A | ASN175 |
| A | LYS191 |
| A | SER193 |
| A | THR203 |
| A | AMP601 |
| A | HOH708 |
| A | HOH742 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | HIS326 |
| A | PRO347 |
| A | GLY348 |
| A | SER349 |
| A | LYS455 |
| A | HOH820 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AMP B 601 |
| Chain | Residue |
| B | HIS164 |
| B | SER165 |
| B | ILE166 |
| B | GLY167 |
| B | GLY168 |
| B | SER193 |
| B | SER194 |
| B | ALA196 |
| B | ILE197 |
| B | THR198 |
| B | SER199 |
| B | THR203 |
| B | ASP256 |
| B | MET261 |
| B | SER264 |
| B | LYS288 |
| B | SO4602 |
| B | HOH795 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | HIS164 |
| B | SER165 |
| B | ASN175 |
| B | LYS191 |
| B | SER193 |
| B | THR203 |
| B | AMP601 |
| B | HOH728 |
| B | HOH785 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | HIS326 |
| B | GLY348 |
| B | SER349 |
| B | LYS455 |
| B | HOH798 |
Functional Information from PROSITE/UniProt
| site_id | PS00430 |
| Number of Residues | 82 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mkakirildmfsgrytvlineedakeaklhpddlvkieagkkavygsvalsnlvgkgevgisrdvldlhnfseg.........................................ETVSVIPA |
| Chain | Residue | Details |
| A | MET1-ALA82 |
| site_id | PS00647 |
| Number of Residues | 16 |
| Details | THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SSRAItsAAGTaDvVE |
| Chain | Residue | Details |
| A | SER193-GLU208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"23659790","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23659790","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
