4G8T
Crystal structure of a glucarate dehydratase related protein, from actinobacillus succinogenes, target EFI-502312, with sodium and sulfate bound, ordered loop
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008872 | molecular_function | glucarate dehydratase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019394 | biological_process | glucarate catabolic process |
| A | 0042838 | biological_process | D-glucarate catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008872 | molecular_function | glucarate dehydratase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019394 | biological_process | glucarate catabolic process |
| B | 0042838 | biological_process | D-glucarate catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008872 | molecular_function | glucarate dehydratase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019394 | biological_process | glucarate catabolic process |
| C | 0042838 | biological_process | D-glucarate catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0008872 | molecular_function | glucarate dehydratase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019394 | biological_process | glucarate catabolic process |
| D | 0042838 | biological_process | D-glucarate catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ASN23 |
| A | HOH625 |
| A | HOH681 |
| A | HOH1103 |
| A | HIS28 |
| A | THR99 |
| A | TYR146 |
| A | PHE148 |
| A | LYS203 |
| A | ASN337 |
| A | HIS364 |
| A | ARG418 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | ASP231 |
| A | ASN233 |
| A | GLU256 |
| A | ASP257 |
| A | ASN285 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | ARG275 |
| A | GLY279 |
| A | LEU280 |
| A | PRO281 |
| A | ASP304 |
| A | HOH799 |
| A | HOH950 |
| A | HOH1102 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | THR86 |
| A | PHE87 |
| A | ASP89 |
| A | HIS90 |
| D | GLY430 |
| D | HOH706 |
| D | HOH957 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DTU A 505 |
| Chain | Residue |
| A | CYS168 |
| A | LYS194 |
| A | HOH629 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | ASN23 |
| B | HIS28 |
| B | THR99 |
| B | TYR146 |
| B | LYS203 |
| B | ASN337 |
| B | HIS364 |
| B | ARG418 |
| B | HOH636 |
| B | HOH654 |
| B | HOH718 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 502 |
| Chain | Residue |
| B | ASP231 |
| B | ASN233 |
| B | GLU256 |
| B | ASP257 |
| B | ASN285 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 503 |
| Chain | Residue |
| A | ASP134 |
| A | GLN323 |
| B | MET80 |
| B | THR314 |
| B | GLN316 |
| B | ARG320 |
| B | HOH713 |
| B | HOH782 |
| B | HOH846 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 504 |
| Chain | Residue |
| A | MET80 |
| A | THR314 |
| A | ARG320 |
| B | GLY133 |
| B | ASP134 |
| B | GLN323 |
| B | HOH705 |
| B | HOH733 |
| B | HOH930 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 505 |
| Chain | Residue |
| B | ARG275 |
| B | GLY279 |
| B | LEU280 |
| B | PRO281 |
| B | ASP304 |
| B | HOH700 |
| B | HOH992 |
| C | ARG276 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 506 |
| Chain | Residue |
| B | THR86 |
| B | PHE87 |
| B | ASP89 |
| B | HIS90 |
| B | HOH899 |
| C | ILE428 |
| C | PRO429 |
| C | GLY430 |
| C | TRP431 |
| C | HOH659 |
| C | HOH760 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DTT B 507 |
| Chain | Residue |
| B | CYS168 |
| B | HOH1024 |
| C | LYS154 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 C 501 |
| Chain | Residue |
| C | HOH634 |
| C | HOH684 |
| C | HOH1012 |
| C | ASN23 |
| C | HIS28 |
| C | THR99 |
| C | TYR146 |
| C | LYS203 |
| C | ASN337 |
| C | HIS364 |
| C | ARG418 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 502 |
| Chain | Residue |
| C | ASP231 |
| C | GLU256 |
| C | ASN285 |
| C | HOH728 |
| C | HOH746 |
| C | HOH1044 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 503 |
| Chain | Residue |
| B | ARG276 |
| B | GLY279 |
| B | HOH700 |
| C | ARG275 |
| C | GLY279 |
| C | LEU280 |
| C | PRO281 |
| C | ASP304 |
| C | HOH897 |
| C | HOH1055 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DTT C 504 |
| Chain | Residue |
| C | CYS168 |
| C | GLU193 |
| C | HOH751 |
| site_id | BC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 D 501 |
| Chain | Residue |
| D | ASN23 |
| D | HIS28 |
| D | THR99 |
| D | PHE148 |
| D | LYS203 |
| D | ASN337 |
| D | HIS364 |
| D | ARG418 |
| D | HOH626 |
| D | HOH635 |
| D | HOH945 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA D 502 |
| Chain | Residue |
| D | ASP231 |
| D | ASN233 |
| D | GLU256 |
| D | ASN285 |
| D | HOH715 |
| D | HOH753 |
| D | HOH1072 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT D 503 |
| Chain | Residue |
| D | CYS168 |
| D | GLU193 |
| D | LYS194 |
| D | HOH689 |
| D | HOH960 |
