4G8M

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE G8M A 301

Chain	Residue
A	TYR58
A	TYR217
A	HOH428
A	HOH529
A	PRO86
A	THR88
A	ARG93
A	LEU135
A	GLY138
A	SER139
A	THR140
A	GLU190

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ARG28
A	HOH402
A	HOH438
A	HOH474
B	LYS180

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	ARG145
A	TRP156
A	ARG160

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG200
A	LYS255
B	HIS20

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	LYS42
A	HIS43
A	PRO164
A	GLN241

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 306

Chain	Residue
A	ASN19

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	ALA60
A	ASP136
A	SER137
A	GLY138
A	LYS141
A	ARG145
A	HOH516

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE G8M B 901

Chain	Residue
B	TYR58
B	PRO86
B	THR88
B	ARG93
B	LEU135
B	GLY138
B	SER139
B	THR140
B	GLU190
B	TYR217
B	HOH1013
B	HOH1025

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 902

Chain	Residue
B	ARG145
B	TRP156
B	ARG160
B	HOH1191

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 903

Chain	Residue
B	LYS113
B	HOH1186

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 904

Chain	Residue
B	HIS43
B	LYS237
B	GLN241

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 905

Chain	Residue
B	LYS1
B	THR2

---

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 906

Chain	Residue
B	SER105

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 907

Chain	Residue
B	ALA60
B	ASP136
B	SER137
B	GLY138
B	LYS141
B	GLU142
B	ARG145

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
B	SER139
B	THR140
B	GLU190
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190
B	PRO86
B	THR88
B	ARG93

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG61
A	ARG145
A	LYS237
B	ARG61
B	ARG145
B	LYS237

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118
B	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147
B	SER147

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181
B	SER181

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0
B	ASN0

---