Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4G5R

Structure of LGN GL4/Galphai3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0007194	biological_process	negative regulation of adenylate cyclase activity
A	0016020	cellular_component	membrane
A	0016239	biological_process	positive regulation of macroautophagy
A	0019001	molecular_function	guanyl nucleotide binding
A	0019003	molecular_function	GDP binding
A	0030496	cellular_component	midbody
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0036064	cellular_component	ciliary basal body
A	0046039	biological_process	GTP metabolic process
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
A	0070062	cellular_component	extracellular exosome
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0001664	molecular_function	G protein-coupled receptor binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
B	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B	0007194	biological_process	negative regulation of adenylate cyclase activity
B	0016020	cellular_component	membrane
B	0016239	biological_process	positive regulation of macroautophagy
B	0019001	molecular_function	guanyl nucleotide binding
B	0019003	molecular_function	GDP binding
B	0030496	cellular_component	midbody
B	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0036064	cellular_component	ciliary basal body
B	0046039	biological_process	GTP metabolic process
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0070062	cellular_component	extracellular exosome
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005765	cellular_component	lysosomal membrane
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005834	cellular_component	heterotrimeric G-protein complex
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
C	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C	0007194	biological_process	negative regulation of adenylate cyclase activity
C	0016020	cellular_component	membrane
C	0016239	biological_process	positive regulation of macroautophagy
C	0019001	molecular_function	guanyl nucleotide binding
C	0019003	molecular_function	GDP binding
C	0030496	cellular_component	midbody
C	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
C	0036064	cellular_component	ciliary basal body
C	0046039	biological_process	GTP metabolic process
C	0046872	molecular_function	metal ion binding
C	0051301	biological_process	cell division
C	0070062	cellular_component	extracellular exosome
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0001664	molecular_function	G protein-coupled receptor binding
D	0003924	molecular_function	GTPase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005765	cellular_component	lysosomal membrane
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005834	cellular_component	heterotrimeric G-protein complex
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
D	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D	0007194	biological_process	negative regulation of adenylate cyclase activity
D	0016020	cellular_component	membrane
D	0016239	biological_process	positive regulation of macroautophagy
D	0019001	molecular_function	guanyl nucleotide binding
D	0019003	molecular_function	GDP binding
D	0030496	cellular_component	midbody
D	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
D	0036064	cellular_component	ciliary basal body
D	0046039	biological_process	GTP metabolic process
D	0046872	molecular_function	metal ion binding
D	0051301	biological_process	cell division
D	0070062	cellular_component	extracellular exosome
E	0030695	molecular_function	GTPase regulator activity
F	0030695	molecular_function	GTPase regulator activity
G	0030695	molecular_function	GTPase regulator activity
Z	0030695	molecular_function	GTPase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP A 401

Chain	Residue
A	ALA41
A	ARG176
A	ARG178
A	ASN269
A	LYS270
A	ASP272
A	LEU273
A	CYS325
A	ALA326
A	THR327
E	ARG635
A	GLU43
E	ARG640
A	SER44
A	GLY45
A	LYS46
A	SER47
A	THR48
A	ASN149
A	SER151

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	HIS213

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP B 401

Chain	Residue
B	GLY42
B	GLU43
B	SER44
B	GLY45
B	LYS46
B	SER47
B	THR48
B	SER151
B	ARG176
B	ARG178
B	ASN269
B	LYS270
B	ASP272
B	LEU273
B	CYS325
B	ALA326
B	THR327
F	ARG635
F	ARG640

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT B 402

Chain	Residue
A	LYS271
A	PHE323
A	ASN331
A	VAL335
B	GLU275
B	THR295
B	TYR296
B	GLU297

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT B 403

Chain	Residue
A	GLU275
A	THR295
A	TYR296
A	GLU297
B	LYS271
B	HIS322
B	PHE323
B	ASN331

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 404

Chain	Residue
B	PHE199
B	HIS213

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP C 401

Chain	Residue
C	GLU43
C	SER44
C	GLY45
C	LYS46
C	SER47
C	THR48
C	ASP150
C	SER151
C	ARG176
C	ARG178
C	ASN269
C	LYS270
C	ASP272
C	LEU273
C	CYS325
C	ALA326
C	THR327
G	ARG635
G	ARG640

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CIT C 402

Chain	Residue
C	LYS271
C	HIS322
C	PHE323
C	ASN331
C	PHE334
D	GLU275
D	TYR296
D	GLU297

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT C 403

Chain	Residue
C	GLU275
C	THR295
C	TYR296
C	GLU297
D	LYS271
D	PHE323
D	ASN331

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 404

Chain	Residue
C	LYS35
C	HIS213

site_id	BC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP D 401

Chain	Residue
D	LYS46
D	SER47
D	THR48
D	ASP150
D	SER151
D	ARG176
D	ARG178
D	ASN269
D	LYS270
D	ASP272
D	LEU273
D	CYS325
D	ALA326
D	THR327
Z	ARG635
Z	ARG640
D	ALA41
D	GLY42
D	GLU43
D	SER44
D	GLY45

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	18
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	28
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	86
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19478087","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IHB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ODE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V4Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"ADP-ribosylarginine; by cholera toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22952234","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4G5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)