Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4G56

Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006479	biological_process	protein methylation
A	0007088	biological_process	regulation of mitotic nuclear division
A	0008168	molecular_function	methyltransferase activity
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018216	biological_process	peptidyl-arginine methylation
A	0032259	biological_process	methylation
A	0032922	biological_process	circadian regulation of gene expression
A	0033314	biological_process	mitotic DNA replication checkpoint signaling
A	0034709	cellular_component	methylosome
A	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
A	0035246	biological_process	peptidyl-arginine N-methylation
A	0044020	molecular_function	histone H4R3 methyltransferase activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0048511	biological_process	rhythmic process
A	0051301	biological_process	cell division
A	0070612	molecular_function	histone H2AR3 methyltransferase activity
A	0070888	molecular_function	E-box binding
A	0090161	biological_process	Golgi ribbon formation
A	1901800	biological_process	positive regulation of proteasomal protein catabolic process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0007309	biological_process	oocyte axis specification
B	0034709	cellular_component	methylosome
B	0035097	cellular_component	histone methyltransferase complex
B	1990234	cellular_component	transferase complex
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006479	biological_process	protein methylation
C	0007088	biological_process	regulation of mitotic nuclear division
C	0008168	molecular_function	methyltransferase activity
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0018216	biological_process	peptidyl-arginine methylation
C	0032259	biological_process	methylation
C	0032922	biological_process	circadian regulation of gene expression
C	0033314	biological_process	mitotic DNA replication checkpoint signaling
C	0034709	cellular_component	methylosome
C	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
C	0035246	biological_process	peptidyl-arginine N-methylation
C	0044020	molecular_function	histone H4R3 methyltransferase activity
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0048511	biological_process	rhythmic process
C	0051301	biological_process	cell division
C	0070612	molecular_function	histone H2AR3 methyltransferase activity
C	0070888	molecular_function	E-box binding
C	0090161	biological_process	Golgi ribbon formation
C	1901800	biological_process	positive regulation of proteasomal protein catabolic process
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0007309	biological_process	oocyte axis specification
D	0034709	cellular_component	methylosome
D	0035097	cellular_component	histone methyltransferase complex
D	1990234	cellular_component	transferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 701

Chain	Residue
A	LEU311
A	MSE416
A	GLU431
A	LEU432
A	LEU433
A	GLU440
A	CYS445
A	TRP575
A	TYR320
A	PHE323
A	LYS329
A	GLY361
A	GLU388
A	LYS389
A	GLY414
A	ASP415

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH C 701

Chain	Residue
C	LEU311
C	TYR320
C	PHE323
C	LYS329
C	GLY361
C	GLU388
C	LYS389
C	GLY414
C	ASP415
C	MSE416
C	GLU431
C	LEU432
C	LEU433
C	GLU440
C	TRP575

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGgkDfSVKVWDL

Chain	Residue	Details
B	ALA130-LEU144

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O14744","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	82
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	80
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	38
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)