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4G56

Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis

Functional Information from GO Data
ChainGOidnamespacecontents
A0003714molecular_functiontranscription corepressor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006355biological_processregulation of DNA-templated transcription
A0006479biological_processprotein methylation
A0007088biological_processregulation of mitotic nuclear division
A0008168molecular_functionmethyltransferase activity
A0008469molecular_functionhistone arginine N-methyltransferase activity
A0016274molecular_functionprotein-arginine N-methyltransferase activity
A0018216biological_processpeptidyl-arginine methylation
A0032259biological_processmethylation
A0032922biological_processcircadian regulation of gene expression
A0033314biological_processmitotic DNA replication checkpoint signaling
A0034709cellular_componentmethylosome
A0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
A0035246biological_processpeptidyl-arginine N-methylation
A0044020molecular_functionhistone H4R3 methyltransferase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0048511biological_processrhythmic process
A0051301biological_processcell division
A0070612molecular_functionhistone H2AR3 methyltransferase activity
A0070888molecular_functionE-box binding
A0090161biological_processGolgi ribbon formation
A1901800biological_processpositive regulation of proteasomal protein catabolic process
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0007309biological_processoocyte axis specification
B0034709cellular_componentmethylosome
B0035097cellular_componenthistone methyltransferase complex
C0003714molecular_functiontranscription corepressor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006479biological_processprotein methylation
C0007088biological_processregulation of mitotic nuclear division
C0008168molecular_functionmethyltransferase activity
C0008469molecular_functionhistone arginine N-methyltransferase activity
C0016274molecular_functionprotein-arginine N-methyltransferase activity
C0018216biological_processpeptidyl-arginine methylation
C0032259biological_processmethylation
C0032922biological_processcircadian regulation of gene expression
C0033314biological_processmitotic DNA replication checkpoint signaling
C0034709cellular_componentmethylosome
C0035243molecular_functionprotein-arginine omega-N symmetric methyltransferase activity
C0035246biological_processpeptidyl-arginine N-methylation
C0044020molecular_functionhistone H4R3 methyltransferase activity
C0045892biological_processnegative regulation of DNA-templated transcription
C0048511biological_processrhythmic process
C0051301biological_processcell division
C0070612molecular_functionhistone H2AR3 methyltransferase activity
C0070888molecular_functionE-box binding
C0090161biological_processGolgi ribbon formation
C1901800biological_processpositive regulation of proteasomal protein catabolic process
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0007309biological_processoocyte axis specification
D0034709cellular_componentmethylosome
D0035097cellular_componenthistone methyltransferase complex
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE SAH A 701
ChainResidue
ALEU311
AMSE416
AGLU431
ALEU432
ALEU433
AGLU440
ACYS445
ATRP575
ATYR320
APHE323
ALYS329
AGLY361
AGLU388
ALYS389
AGLY414
AASP415

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE SAH C 701
ChainResidue
CLEU311
CTYR320
CPHE323
CLYS329
CGLY361
CGLU388
CLYS389
CGLY414
CASP415
CMSE416
CGLU431
CLEU432
CLEU433
CGLU440
CTRP575

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGgkDfSVKVWDL
ChainResidueDetails
BALA130-LEU144

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250
ChainResidueDetails
AGLU431
AGLU440
CGLU431
CGLU440

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING:
ChainResidueDetails
ATYR320
CGLU440
ALYS329
AGLU388
AGLY414
AGLU440
CTYR320
CLYS329
CGLU388
CGLY414

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O14744
ChainResidueDetails
APHE323
AGLU431
CPHE323
CGLU431

224201

PDB entries from 2024-08-28

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