4G3D

Crystal structure of human NF-kappaB inducing kinase (NIK)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 701

Chain	Residue
A	ASN520
A	ASP534
A	HOH805

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 701

Chain	Residue
D	SER410
D	ASN520
D	ASP534

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 701

Chain	Residue
E	ASN520
E	ASP534

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGSFGEVHrMedkqtgfqc.........AVKK

Chain	Residue	Details
A	LEU406-LYS430

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IlHgDVKadNVLL

Chain	Residue	Details
A	ILE511-LEU523

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP515
B	ASP515
D	ASP515
E	ASP515

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
D	LEU406
D	LYS429
E	LEU406
E	LYS429
A	LEU406
A	LYS429
B	LEU406
B	LYS429

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20682767

Chain	Residue	Details
A	THR559
B	THR559
D	THR559
E	THR559

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