4G2C
DyP2 from Amycolatopsis sp. ATCC 39116
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016689 | molecular_function | manganese peroxidase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052750 | molecular_function | reactive-black-5:hydrogen-peroxide oxidoreductase activity |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140825 | molecular_function | lactoperoxidase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016689 | molecular_function | manganese peroxidase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052750 | molecular_function | reactive-black-5:hydrogen-peroxide oxidoreductase activity |
| B | 0055114 | biological_process | obsolete oxidation-reduction process |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140825 | molecular_function | lactoperoxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM A 501 |
| Chain | Residue |
| A | GLU186 |
| A | ILE324 |
| A | THR327 |
| A | ASN328 |
| A | ARG330 |
| A | ARG348 |
| A | PHE378 |
| A | PHE389 |
| A | GLN393 |
| A | ILE417 |
| A | VAL447 |
| A | TYR190 |
| A | HOH611 |
| A | HOH628 |
| A | HOH629 |
| A | HOH710 |
| A | VAL191 |
| A | ASP192 |
| A | GLY193 |
| A | ARG194 |
| A | SER195 |
| A | GLN251 |
| A | HIS323 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 502 |
| Chain | Residue |
| A | GLU260 |
| A | GLU286 |
| A | HOH677 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 503 |
| Chain | Residue |
| A | GLU224 |
| A | LYS343 |
| A | SER383 |
| A | ASN387 |
| A | GLN388 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 504 |
| Chain | Residue |
| A | PRO302 |
| A | GLY304 |
| A | HOH633 |
| B | GLN294 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 505 |
| Chain | Residue |
| A | ARG208 |
| A | VAL214 |
| A | ASP218 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 506 |
| Chain | Residue |
| A | ASP216 |
| A | SER308 |
| A | ASP310 |
| A | ARG367 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 507 |
| Chain | Residue |
| A | GLY315 |
| A | PRO319 |
| A | PHE320 |
| A | LYS426 |
| A | TYR427 |
| A | ACT508 |
| A | HOH711 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 508 |
| Chain | Residue |
| A | SER409 |
| A | PRO411 |
| A | ACT507 |
| A | HOH746 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 509 |
| Chain | Residue |
| A | SER311 |
| A | ASP312 |
| A | LYS313 |
| A | LEU314 |
| A | HOH795 |
| B | ASP209 |
| B | ACT511 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 510 |
| Chain | Residue |
| A | ALA34 |
| A | ARG37 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 511 |
| Chain | Residue |
| A | LYS120 |
| A | GLY386 |
| A | GLU390 |
| A | PHE391 |
| A | GLN394 |
| A | HOH708 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 512 |
| Chain | Residue |
| A | ASP205 |
| A | ARG208 |
| A | ASP209 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 513 |
| Chain | Residue |
| A | ASP192 |
| A | GLY350 |
| A | HOH831 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 514 |
| Chain | Residue |
| A | ASN58 |
| A | LEU466 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 515 |
| Chain | Residue |
| A | ARG254 |
| A | GLU340 |
| A | LYS343 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 516 |
| Chain | Residue |
| A | ALA112 |
| A | PRO406 |
| A | ASP407 |
| A | GLY408 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 517 |
| Chain | Residue |
| A | GLU73 |
| A | VAL74 |
| A | VAL83 |
| A | GLY84 |
| A | HOH707 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 518 |
| Chain | Residue |
| A | ARG39 |
| A | LEU40 |
| A | THR41 |
| A | GLY174 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 519 |
| Chain | Residue |
| A | ALA98 |
| A | THR99 |
| A | ALA335 |
| A | ILE395 |
| A | ASN399 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 520 |
| Chain | Residue |
| A | ALA221 |
| A | PRO222 |
| A | ACT527 |
| A | HOH754 |
| A | THR9 |
| A | SER220 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 521 |
| Chain | Residue |
| A | PRO197 |
| A | PRO219 |
| A | SER220 |
| A | ALA221 |
| A | GLN225 |
| A | ARG342 |
| A | LEU345 |
| A | HOH809 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 522 |
| Chain | Residue |
| A | ALA34 |
| A | PRO197 |
| A | LEU198 |
| A | ARG349 |
| A | HOH768 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 523 |
| Chain | Residue |
| A | LEU413 |
| A | ARG422 |
| A | ALA423 |
| A | GLN425 |
| A | PRO442 |
| A | ILE443 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 524 |
| Chain | Residue |
| A | PRO108 |
| A | THR111 |
| A | ALA112 |
| A | ASP407 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 525 |
| Chain | Residue |
| A | SER109 |
| A | ALA112 |
| A | GLY113 |
| A | ALA116 |
| A | ALA117 |
| A | LYS120 |
| A | GLU390 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 526 |
| Chain | Residue |
| A | GLY176 |
| A | LEU177 |
| A | ALA178 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 527 |
| Chain | Residue |
| A | THR10 |
| A | THR201 |
| A | VAL204 |
| A | SER220 |
| A | HIS357 |
| A | ACT520 |
| site_id | DC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM B 501 |
| Chain | Residue |
| B | GLU186 |
| B | TYR190 |
| B | VAL191 |
| B | ASP192 |
| B | GLY193 |
| B | ARG194 |
| B | SER195 |
| B | GLN251 |
| B | ARG284 |
| B | HIS323 |
| B | THR327 |
| B | ASN328 |
| B | ARG330 |
| B | ARG348 |
| B | PHE378 |
| B | PHE389 |
| B | ILE417 |
| B | HOH618 |
| B | HOH619 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN B 502 |
| Chain | Residue |
| B | GLU260 |
| B | GLU286 |
| B | ACT514 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 503 |
| Chain | Residue |
| A | ARG208 |
| A | ASP209 |
| B | SER311 |
| B | ASP312 |
| B | LYS313 |
| B | LEU314 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 504 |
| Chain | Residue |
| A | ASN215 |
| A | PRO365 |
| A | ARG367 |
| B | ASP310 |
| B | HOH734 |
| site_id | DC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 505 |
| Chain | Residue |
| B | PRO415 |
| B | ARG422 |
| B | ALA423 |
| B | GLN425 |
| B | PRO442 |
| B | ILE443 |
| B | HOH607 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 506 |
| Chain | Residue |
| B | GLY315 |
| B | PRO319 |
| B | PHE320 |
| B | HIS321 |
| B | LYS426 |
| B | TYR427 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 507 |
| Chain | Residue |
| B | VAL36 |
| B | HIS70 |
| B | GLU73 |
| B | VAL74 |
| B | VAL83 |
| B | HOH733 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 508 |
| Chain | Residue |
| B | ARG39 |
| B | LEU40 |
| B | THR41 |
| B | GLY174 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 509 |
| Chain | Residue |
| B | ALA106 |
| B | VAL228 |
| B | PRO229 |
| B | TYR243 |
| B | HOH753 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 510 |
| Chain | Residue |
| A | ASP310 |
| A | SER311 |
| B | ARG208 |
| B | ASN215 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 511 |
| Chain | Residue |
| A | ACT509 |
| B | ARG208 |
| B | ASP209 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 512 |
| Chain | Residue |
| B | LYS33 |
| B | ALA34 |
| B | ARG349 |
| B | HOH666 |
| site_id | EC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 513 |
| Chain | Residue |
| B | THR93 |
| B | ALA94 |
| B | HIS95 |
| B | ILE137 |
| B | GLU453 |
| B | HOH645 |
| B | HOH732 |
| site_id | EC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 514 |
| Chain | Residue |
| B | TYR190 |
| B | GLU275 |
| B | PHE285 |
| B | GLU286 |
| B | MN502 |
| B | HOH655 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 515 |
| Chain | Residue |
| A | ASP209 |
| A | HOH706 |
| B | GLN316 |
| B | GLY432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q47KB1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23054399","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"23054399","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4G2C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
