4G0N
Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GNP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | ASP30 |
| A | GLU31 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | GLY13 |
| A | ALA146 |
| A | LYS147 |
| A | MG203 |
| A | HOH301 |
| A | HOH317 |
| A | HOH335 |
| A | HOH344 |
| A | HOH364 |
| A | HOH365 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 202 |
| Chain | Residue |
| A | ASP107 |
| A | TYR137 |
| A | ACT205 |
| A | HOH345 |
| A | HOH346 |
| A | HOH347 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 203 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | ASP57 |
| A | GNP201 |
| A | HOH335 |
| A | HOH344 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 204 |
| Chain | Residue |
| A | HOH332 |
| A | HOH332 |
| A | HOH332 |
| A | HOH333 |
| A | HOH333 |
| A | HOH333 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 205 |
| Chain | Residue |
| A | ARG97 |
| A | ASP107 |
| A | ASP108 |
| A | VAL109 |
| A | MET111 |
| A | TYR137 |
| A | CA202 |
| A | HOH345 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTU A 206 |
| Chain | Residue |
| A | ARG68 |
| A | ASP92 |
| A | GLN95 |
| A | TYR96 |
| A | GLN99 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 75 |
| Details | Domain: {"description":"RBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00262","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
