Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 501 |
Chain | Residue |
A | HIS222 |
A | HIS226 |
A | HIS232 |
C | SER45 |
C | HOH204 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 502 |
Chain | Residue |
A | HIS172 |
A | ASP174 |
A | HIS187 |
A | HIS200 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 503 |
Chain | Residue |
A | ASP179 |
A | GLY180 |
A | SER182 |
A | LEU184 |
A | ASP202 |
A | GLU205 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 504 |
Chain | Residue |
A | ASP162 |
A | ASN194 |
A | GLY196 |
A | ASP198 |
A | HOH619 |
A | HOH663 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CA A 505 |
Chain | Residue |
A | ASP291 |
A | ASP335 |
A | SER383 |
A | ASP432 |
A | HOH605 |
A | HOH612 |
A | HOH669 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 506 |
Chain | Residue |
A | ILE293 |
A | ALA337 |
A | ALA385 |
A | VAL434 |
A | CL508 |
A | CL509 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA A 507 |
Chain | Residue |
A | ASP128 |
A | ASP203 |
A | GLU205 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CL A 508 |
Chain | Residue |
A | ALA292 |
A | ILE293 |
A | ALA337 |
A | ALA385 |
A | ALA433 |
A | VAL434 |
A | CA506 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 509 |
Chain | Residue |
A | ILE293 |
A | THR294 |
A | CA506 |
A | HOH621 |
A | HOH647 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 510 |
Chain | Residue |
A | LYS140 |
A | ASN215 |
A | TYR246 |
A | GLY248 |
A | LYS249 |
A | SER250 |
A | HIS251 |
A | PHE252 |
A | PGO520 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 512 |
Chain | Residue |
A | SER289 |
A | LEU290 |
A | ASP291 |
A | ASP432 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 513 |
Chain | Residue |
A | THR247 |
A | MET253 |
A | ARG306 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PGO A 514 |
Chain | Residue |
A | PRO236 |
A | GLY237 |
A | ALA238 |
A | ILE243 |
A | THR245 |
A | LEU322 |
A | HOH631 |
C | TYR46 |
C | HOH202 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PGO A 515 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 516 |
Chain | Residue |
A | GLY439 |
A | PGO517 |
B | ASP128 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO A 517 |
Chain | Residue |
A | TYR440 |
A | TRP455 |
A | PGO516 |
A | HOH675 |
B | PRO127 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 518 |
Chain | Residue |
A | GLU389 |
A | THR391 |
A | GLY392 |
site_id | BC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PGO A 519 |
Chain | Residue |
A | PRO281 |
A | ASP282 |
A | ASP285 |
A | SER287 |
A | LEU288 |
A | LYS304 |
A | PEG531 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO A 520 |
Chain | Residue |
A | LYS136 |
A | SER209 |
A | ASN215 |
A | GOL510 |
A | HOH650 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO A 521 |
Chain | Residue |
A | SER210 |
A | HOH680 |
B | TRP455 |
A | THR208 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PGO A 522 |
Chain | Residue |
A | GLN401 |
A | PRO417 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 523 |
Chain | Residue |
A | TYR125 |
A | HIS131 |
A | LEU419 |
site_id | CC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PGO A 524 |
Chain | Residue |
A | SER295 |
A | GLU339 |
A | PRO341 |
A | HIS387 |
A | GLU389 |
A | GLU436 |
A | HOH647 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO A 525 |
Chain | Residue |
A | TYR440 |
A | SER453 |
A | TRP455 |
A | SER456 |
A | VAL460 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO A 526 |
Chain | Residue |
A | TYR416 |
A | ARG418 |
A | ASP423 |
site_id | CC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PGO A 527 |
Chain | Residue |
A | TYR366 |
A | PRO367 |
site_id | CC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PEG A 528 |
Chain | Residue |
A | THR300 |
A | LEU311 |
A | ILE468 |
A | TRP470 |
A | HOH651 |
A | HOH654 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PEG A 529 |
Chain | Residue |
A | GLY248 |
A | LYS324 |
A | PRO331 |
A | ASN332 |
A | ARG333 |
A | ARG350 |
D | GLU33 |
site_id | DC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG A 530 |
Chain | Residue |
A | THR280 |
A | ASP282 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PEG A 531 |
Chain | Residue |
A | SER287 |
A | LEU288 |
A | SER289 |
A | LYS304 |
A | GLY446 |
A | PRO447 |
A | PGO519 |
site_id | DC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEG A 532 |
Chain | Residue |
A | PRO313 |
A | GLN314 |
A | SER325 |
C | PRO49 |
C | THR50 |
site_id | DC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 501 |
Chain | Residue |
B | HIS222 |
B | HIS226 |
B | HIS232 |
D | SER45 |
D | HOH207 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 502 |
Chain | Residue |
B | HIS172 |
B | ASP174 |
B | HIS187 |
B | HIS200 |
site_id | DC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 503 |
Chain | Residue |
B | ASP179 |
B | GLY180 |
B | SER182 |
B | LEU184 |
B | ASP202 |
B | GLU205 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 504 |
Chain | Residue |
B | ASP162 |
B | ASN194 |
B | GLY196 |
B | ASP198 |
B | HOH633 |
B | HOH713 |
site_id | DC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CA B 505 |
Chain | Residue |
B | ASP291 |
B | ASP335 |
B | SER383 |
B | ASP432 |
B | HOH606 |
B | HOH615 |
B | HOH661 |
site_id | EC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 506 |
Chain | Residue |
B | ILE293 |
B | ALA337 |
B | ALA385 |
B | VAL434 |
B | CL508 |
B | HOH617 |
site_id | EC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA B 507 |
Chain | Residue |
B | ASP128 |
B | ASP203 |
B | GLU205 |
site_id | EC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL B 508 |
Chain | Residue |
B | ILE293 |
B | ALA337 |
B | ALA385 |
B | VAL434 |
B | CA506 |
site_id | EC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 509 |
Chain | Residue |
B | GLU133 |
B | LYS136 |
B | LYS140 |
B | SER209 |
B | ASN215 |
B | GOL513 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 510 |
Chain | Residue |
B | HIS343 |
B | ASN358 |
B | HOH690 |
site_id | EC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 511 |
Chain | Residue |
A | PRO464 |
B | ASN445 |
B | ILE448 |
site_id | EC7 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 512 |
Chain | Residue |
A | ARG458 |
A | ILE459 |
A | VAL460 |
A | ARG461 |
B | GLU421 |
B | GLY426 |
B | ILE427 |
B | GLY428 |
B | HOH625 |
site_id | EC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL B 513 |
Chain | Residue |
B | LYS140 |
B | ASN215 |
B | TYR246 |
B | GLY248 |
B | LYS249 |
B | SER250 |
B | PHE252 |
B | GOL509 |
site_id | EC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 514 |
Chain | Residue |
B | LYS380 |
B | SER398 |
site_id | FC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 515 |
Chain | Residue |
B | PRO313 |
B | LYS437 |
B | HOH637 |
B | HOH658 |
D | PRO49 |
D | THR50 |
site_id | FC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO B 516 |
Chain | Residue |
B | LYS234 |
B | ASP235 |
B | PRO236 |
B | HOH687 |
site_id | FC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO B 517 |
Chain | Residue |
B | TYR195 |
B | ASP198 |
B | HIS200 |
site_id | FC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO B 518 |
Chain | Residue |
B | PRO376 |
B | GLU378 |
B | GLN401 |
site_id | FC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO B 519 |
Chain | Residue |
B | SER146 |
B | THR149 |
B | PRO150 |
B | LEU151 |
B | HOH715 |
site_id | FC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO B 520 |
Chain | Residue |
B | HIS232 |
B | SER233 |
B | LYS234 |
B | PRO242 |
D | PEG101 |
site_id | FC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PGO B 521 |
Chain | Residue |
B | THR110 |
B | LYS112 |
B | SER114 |
B | GLY192 |
B | HOH708 |
site_id | FC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO B 522 |
Chain | Residue |
B | TYR435 |
B | LYS437 |
B | GLN449 |
B | MET463 |
site_id | FC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO B 524 |
Chain | Residue |
B | MET253 |
B | PRO255 |
B | PRO278 |
B | ARG306 |
site_id | GC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PGO B 525 |
Chain | Residue |
B | HIS340 |
B | HIS387 |
B | ASP407 |
B | HOH691 |
site_id | GC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PGO B 526 |
Chain | Residue |
B | ARG297 |
B | ASP344 |
site_id | GC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PGO B 527 |
Chain | Residue |
B | ASP282 |
B | ASP285 |
site_id | GC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEG B 528 |
Chain | Residue |
B | SER211 |
B | THR245 |
B | TYR246 |
B | HOH712 |
D | HIS48 |
site_id | GC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PEG B 529 |
Chain | Residue |
B | TYR104 |
B | HOH669 |
site_id | GC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PEG B 530 |
Chain | Residue |
B | PRO236 |
B | PHE241 |
B | ILE243 |
B | THR245 |
B | GLN314 |
B | LEU322 |
B | SER325 |
B | HOH624 |
B | HOH692 |
site_id | GC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGO C 101 |
Chain | Residue |
C | ALA39 |
C | ARG41 |
C | TYR42 |
site_id | GC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PEG D 101 |
Chain | Residue |
B | PRO242 |
B | PGO520 |
D | ARG44 |
D | SER45 |
D | TYR47 |
D | HOH206 |
D | HOH210 |
Functional Information from PROSITE/UniProt
site_id | PS00024 |
Number of Residues | 16 |
Details | HEMOPEXIN Hemopexin domain signature. TKsfWpelPnRIDAAY |
Chain | Residue | Details |
A | THR323-TYR338 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA223 | |
B | ALA223 | |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
Chain | Residue | Details |
A | ASP128 | |
A | ASP202 | |
A | ASP203 | |
A | GLU205 | |
A | ASP291 | |
A | ILE293 | |
A | ASP335 | |
A | ALA337 | |
A | SER383 | |
A | ALA385 | |
A | ASP432 | |
A | ASP162 | |
A | VAL434 | |
B | ASP128 | |
B | ASP162 | |
B | ASP179 | |
B | GLY180 | |
B | SER182 | |
B | LEU184 | |
B | ASN194 | |
B | GLY196 | |
B | ASP198 | |
A | ASP179 | |
B | ASP202 | |
B | ASP203 | |
B | GLU205 | |
B | ASP291 | |
B | ILE293 | |
B | ASP335 | |
B | ALA337 | |
B | SER383 | |
B | ALA385 | |
B | ASP432 | |
A | GLY180 | |
B | VAL434 | |
A | SER182 | |
A | LEU184 | |
A | ASN194 | |
A | GLY196 | |
A | ASP198 | |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
Chain | Residue | Details |
A | HIS172 | |
B | ASP174 | |
B | HIS187 | |
B | HIS200 | |
B | HIS222 | |
B | HIS226 | |
B | HIS232 | |
B | MET240 | |
A | ASP174 | |
A | HIS187 | |
A | HIS200 | |
A | HIS222 | |
A | HIS226 | |
A | HIS232 | |
A | MET240 | |
B | HIS172 | |
Chain | Residue | Details |
A | TYR366 | |
B | TYR366 | |
Chain | Residue | Details |
A | ASN117 | |
B | ASN117 | |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN152 | |
B | ASN152 | |