Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FU4

Human collagenase 3 (MMP-13) with peptide from pro-domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS222
A	HIS226
A	HIS232
C	ALA39
C	GLU40
C	CL101

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS200
A	HIS172
A	ASP174
A	HIS187

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP179
A	GLY180
A	SER182
A	LEU184
A	ASP202
A	GLU205

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	ASP162
A	ASN194
A	GLY196
A	ASP198

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 505

Chain	Residue
A	ASP291
A	ASP335
A	SER383
A	ASP432
A	HOH610

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 506

Chain	Residue
A	ILE293
A	ALA337
A	ALA385
A	VAL434
A	CL507

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 507

Chain	Residue
A	ILE293
A	ALA337
A	ALA385
A	VAL434
A	CA506

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 508

Chain	Residue
A	SER467

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 509

Chain	Residue
A	TYR440
A	GLU451
A	ARG461
C	ARG44

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 510

Chain	Residue
A	TYR416
A	ASP423
A	EDO514

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 511

Chain	Residue
A	HOH609

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 512

Chain	Residue
A	ASN194
A	TYR195

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 513

Chain	Residue
A	THR247
A	MET253
A	ARG306

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 514

Chain	Residue
A	EDO510

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 515

Chain	Residue
A	TYR440
A	TRP455

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 516

Chain	Residue
A	TYR104
A	ASN105
A	HOH626

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 517

Chain	Residue
A	GLN263
A	SER264

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 518

Chain	Residue
A	LYS234
A	ASP317

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
B	HIS222
B	HIS226
B	HIS232
D	SER45
D	CL101

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 502

Chain	Residue
B	HIS172
B	ASP174
B	HIS187
B	HIS200

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 503

Chain	Residue
B	ASP179
B	GLY180
B	SER182
B	LEU184
B	ASP202
B	GLU205

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 504

Chain	Residue
B	ASP162
B	ASN194
B	GLY196
B	ASP198

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 505

Chain	Residue
B	ASP291
B	ASP335
B	SER383
B	ASP432
B	HOH636
B	HOH653

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 506

Chain	Residue
B	ILE293
B	ALA337
B	ALA385
B	VAL434
B	CL507
B	HOH635

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 507

Chain	Residue
B	ALA292
B	ILE293
B	ALA337
B	ALA433
B	VAL434
B	CA506

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 508

Chain	Residue
B	PHE326
B	GLY359

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 509

Chain	Residue
B	ASP203
B	ASP204
B	GLU205
B	THR206
B	ASP128

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 510

Chain	Residue
B	THR247
B	PHE252
B	MET253
B	PRO255

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 511

Chain	Residue
A	PRO464
B	ASN445
B	ILE448

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 512

Chain	Residue
B	PRO236
B	THR280
B	PRO281
B	HOH645

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 513

Chain	Residue
B	THR391
B	LYS393
B	ILE454

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 514

Chain	Residue
B	TYR104

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 515

Chain	Residue
B	GLN260
B	SER264

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 516

Chain	Residue
B	GLN263
B	GLY267

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 517

Chain	Residue
B	GLY248
B	LYS249
B	SER250
B	HIS251
B	PHE252

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 518

Chain	Residue
B	LYS437
B	TYR442
B	GLN449
B	EDO519

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 519

Chain	Residue
B	TRP470
B	EDO518
D	TYR47

site_id	EC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 520

Chain	Residue
B	SER146
B	THR149
B	PRO150
B	LEU151
B	ASN152
B	GLY269
B	ASP270
B	HOH641

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL C 101

Chain	Residue
A	ALA186
A	HIS187
A	HIS226
A	ZN501
C	PHE38
C	ALA39
C	GLU40

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 102

Chain	Residue
A	ARG297
C	PRO49

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL D 101

Chain	Residue
B	HIS222
B	HIS226
B	ZN501
D	ARG44
D	SER45
D	TYR46

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D 102

Chain	Residue
B	HIS232
D	ARG44
D	SER45
D	TYR47

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. TKsfWpelPnRIDAAY

Chain	Residue	Details
A	THR323-TYR338

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Repeat: {"description":"Hemopexin 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	92
Details	Repeat: {"description":"Hemopexin 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	96
Details	Repeat: {"description":"Hemopexin 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	86
Details	Repeat: {"description":"Hemopexin 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	140
Details	Region: {"description":"Interaction with TIMP2"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	42
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	406
Details	Region: {"description":"Interaction with collagen"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8969305","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by PKDCC","evidences":[{"source":"PubMed","id":"25171405","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8576151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)