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4FS2

Base pairing mechanism of N2,3-ethenoguanine with dCTP by human polymerase iota

Functional Information from GO Data
ChainGOidnamespacecontents
A0003684molecular_functiondamaged DNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006281biological_processDNA repair
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 501
ChainResidue
AASP34
ALEU35
AASP126
ADCP503
AMG505

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 502
ChainResidue
BDC12
BHOH101
ALYS237
AILE239
AILE242
AHOH677

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE DCP A 503
ChainResidue
AASP34
ALEU35
AASP36
ACYS37
APHE38
ATYR39
AVAL64
ATHR65
ATYR68
AARG71
ALYS77
AASP126
ALYS214
AMG501
AMG505
AHOH653
BDOC13
CEFG840
CDG841

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 504
ChainResidue
ASER106
AARG122
AGLY124
APHE125
AGLU127
AASN128
AHOH601

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 505
ChainResidue
AASP34
AASP126
AGLU127
AMG501
ADCP503
BDOC13

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216
ChainResidueDetails
AGLU127

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5
ChainResidueDetails
AASP34
ALEU35
AASP126

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N
ChainResidueDetails
ATYR39
AARG71

227111

PDB entries from 2024-11-06

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