4FRR
X-ray structure of Acetylcholine binding protein from Aplysia californica in presence of 3-((S)-azetidin-2-ylmethoxy)-5-((1S,2R)-2-(2-methoxyethyl)cyclopropyl)pyridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0VC A 301 |
| Chain | Residue |
| A | TYR93 |
| A | TRP147 |
| A | CYS190 |
| A | TYR195 |
| E | ARG79 |
| E | VAL108 |
| E | MET116 |
| E | ILE118 |
| E | HOH413 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | GLN58 |
| A | THR87 |
| A | PRO88 |
| A | ILE90 |
| A | PHE117 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | SER95 |
| A | ARG97 |
| A | PRO98 |
| A | VAL99 |
| A | HOH420 |
| E | VAL101 |
| E | LEU102 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | PRO21 |
| A | TRP86 |
| A | TYR149 |
| E | ARG79 |
| E | THR80 |
| E | SER81 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | GLN38 |
| A | SER167 |
| A | TYR169 |
| A | HOH447 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | LYS143 |
| A | GLN184 |
| A | GLN186 |
| C | ARG183 |
| C | PRO194 |
| C | ILE196 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 301 |
| Chain | Residue |
| B | GLU56 |
| B | GLN58 |
| B | ILE90 |
| B | GLN121 |
| B | HOH450 |
| B | HOH456 |
| B | HOH479 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| A | SER81 |
| A | ILE106 |
| B | PRO21 |
| B | TRP86 |
| B | TYR149 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0VC C 301 |
| Chain | Residue |
| B | ARG79 |
| B | VAL108 |
| B | MET116 |
| B | ILE118 |
| C | TYR93 |
| C | TRP147 |
| C | VAL148 |
| C | CYS190 |
| C | TYR195 |
| C | HOH414 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 302 |
| Chain | Residue |
| C | THR130 |
| C | GLY137 |
| C | THR139 |
| C | HOH479 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 303 |
| Chain | Residue |
| C | GLU56 |
| C | GLN58 |
| C | THR87 |
| C | PRO88 |
| C | ILE90 |
| C | PHE117 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL D 301 |
| Chain | Residue |
| D | TRP147 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 302 |
| Chain | Residue |
| D | ASN70 |
| D | ASN74 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0VC E 301 |
| Chain | Residue |
| D | ARG79 |
| D | VAL108 |
| D | MET116 |
| D | ILE118 |
| E | TYR93 |
| E | TRP147 |
| E | VAL148 |
| E | TYR188 |
| E | CYS190 |
| E | CYS191 |
| E | TYR195 |
| E | HOH407 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 302 |
| Chain | Residue |
| A | TYR93 |
| A | HOH488 |
| E | GLN38 |
| E | SER167 |
| E | TYR169 |
| E | HOH416 |
| E | HOH443 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL E 303 |
| Chain | Residue |
| B | THR76 |
| E | HOH457 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 304 |
| Chain | Residue |
| E | PRO88 |
| E | ILE90 |
| E | HOH439 |
| site_id | BC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0VC F 301 |
| Chain | Residue |
| F | CYS190 |
| F | CYS191 |
| F | TYR195 |
| J | ARG79 |
| J | VAL108 |
| J | MET116 |
| J | HOH422 |
| F | TYR93 |
| F | TRP147 |
| F | VAL148 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 302 |
| Chain | Residue |
| F | TRP86 |
| F | TYR149 |
| F | HOH457 |
| J | LYS10 |
| J | ARG79 |
| J | THR80 |
| J | SER81 |
| J | ILE106 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL F 303 |
| Chain | Residue |
| F | TYR54 |
| F | GLU56 |
| F | ILE90 |
| F | VAL99 |
| F | GLN121 |
| F | HOH417 |
| F | HOH431 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL G 301 |
| Chain | Residue |
| G | HOH459 |
| G | HOH460 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL G 302 |
| Chain | Residue |
| G | LEU165 |
| G | TYR168 |
| G | GLU175 |
| G | ILE176 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL G 303 |
| Chain | Residue |
| G | GLU56 |
| G | GLN58 |
| G | PRO88 |
| G | ILE90 |
| G | HOH451 |
| G | HOH466 |
| G | HOH468 |
| site_id | CC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0VC H 301 |
| Chain | Residue |
| G | ARG79 |
| G | MET116 |
| G | ILE118 |
| G | HOH412 |
| H | TYR93 |
| H | TRP147 |
| H | CYS190 |
| H | CYS191 |
| H | TYR195 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL H 302 |
| Chain | Residue |
| H | GLN58 |
| H | THR87 |
| H | PRO88 |
| H | PHE117 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL I 301 |
| Chain | Residue |
| I | GLN100 |
| I | VAL101 |
| I | HOH480 |
| J | PRO98 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL I 302 |
| Chain | Residue |
| I | TRP147 |
| I | HOH430 |
| I | HOH488 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL I 303 |
| Chain | Residue |
| H | GLN3 |
| I | LYS61 |
| I | ASN63 |
| I | SER64 |
| I | HOH481 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 0VC J 301 |
| Chain | Residue |
| I | ARG79 |
| I | VAL108 |
| I | ILE118 |
| J | TYR93 |
| J | TRP147 |
| J | VAL148 |
| J | CYS191 |
| J | TYR195 |
| J | HOH402 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL J 302 |
| Chain | Residue |
| F | MET126 |
| F | HOH430 |
| J | GLN38 |
| J | SER167 |
| J | HOH419 |
| J | HOH444 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL J 303 |
| Chain | Residue |
| I | LYS10 |
| I | ARG79 |
| J | PRO21 |
| J | TRP86 |
| J | TYR149 |
| J | HOH423 |
