4FMM
Dimeric Sec14 family homolog 3 from Saccharomyces cerevisiae presents some novel features of structure that lead to a surprising "dimer-monomer" state change induced by substrate binding
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0008526 | molecular_function | phosphatidylinositol transfer activity |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016126 | biological_process | sterol biosynthetic process |
| A | 0032934 | molecular_function | sterol binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043942 | biological_process | negative regulation of sexual sporulation resulting in formation of a cellular spore |
| A | 0071561 | cellular_component | nucleus-vacuole junction |
| A | 0071944 | cellular_component | cell periphery |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006869 | biological_process | lipid transport |
| B | 0008526 | molecular_function | phosphatidylinositol transfer activity |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0015914 | biological_process | phospholipid transport |
| B | 0016126 | biological_process | sterol biosynthetic process |
| B | 0032934 | molecular_function | sterol binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043942 | biological_process | negative regulation of sexual sporulation resulting in formation of a cellular spore |
| B | 0071561 | cellular_component | nucleus-vacuole junction |
| B | 0071944 | cellular_component | cell periphery |
| B | 0120009 | biological_process | intermembrane lipid transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | TRP84 |
| A | ARG92 |
| A | ILE185 |
| A | ARG236 |
| A | GLU330 |
| A | ARG334 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | HOH601 |
| A | LEU229 |
| A | GLN230 |
| A | TYR233 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | PRO273 |
| A | PHE274 |
| A | TYR287 |
| A | HOH606 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | MET188 |
| A | LYS311 |
| A | HIS314 |
| A | ARG334 |
| A | HOH582 |
| A | HOH589 |
| A | HOH614 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | GLY220 |
| A | GLY222 |
| A | LYS223 |
| B | TRP250 |
| B | ASP271 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 406 |
| Chain | Residue |
| A | LYS144 |
| A | GLN145 |
| A | GLN165 |
| A | HOH548 |
| B | TRP247 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 407 |
| Chain | Residue |
| A | THR64 |
| A | ASN68 |
| A | ASP73 |
| A | HOH537 |
| A | HOH562 |
| B | LYS223 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 401 |
| Chain | Residue |
| B | TRP84 |
| B | CYS89 |
| B | ARG92 |
| B | ILE185 |
| B | ARG236 |
| B | GLU330 |
| B | ARG334 |
| B | HOH505 |
| B | HOH644 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 402 |
| Chain | Residue |
| B | THR243 |
| B | TYR287 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| A | TRP247 |
| B | GLY220 |
| B | GLY222 |
| B | LYS223 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 404 |
| Chain | Residue |
| B | TRP84 |
| B | TYR93 |
| B | HIS232 |
| B | PRO234 |
| B | HOH505 |
| B | HOH547 |
| B | HOH548 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 405 |
| Chain | Residue |
| B | LYS26 |
| B | TYR150 |
| B | PHE187 |
| B | LYS311 |
| B | HOH546 |
