4FMB

VirA-Rab1 complex structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0004197	molecular_function	cysteine-type endopeptidase activity
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
E	0004197	molecular_function	cysteine-type endopeptidase activity
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AF3 B 201

Chain	Residue
A	ARG188
B	GDP202
B	MG203
B	HOH301
B	HOH303
A	GLN280
B	SER20
B	GLY21
B	LYS24
B	SER42
B	THR43
B	THR67
B	GLY69

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GDP B 202

Chain	Residue
A	ARG188
A	ARG191
B	ASP19
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	CYS26
B	TYR36
B	ASN124
B	LYS125
B	ASP127
B	LEU128
B	SER154
B	ALA155
B	LYS156
B	AF3201
B	MG203
B	HOH302
B	HOH303

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 203

Chain	Residue
B	SER25
B	THR43
B	AF3201
B	GDP202
B	HOH302
B	HOH303

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AF3 D 201

Chain	Residue
C	ARG188
C	GLN280
C	HOH501
D	SER20
D	GLY21
D	LYS24
D	SER42
D	THR43
D	THR67
D	GLY69
D	GDP202
D	MG203
D	HOH302

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP D 202

Chain	Residue
C	ARG188
C	ARG191
D	ASP19
D	GLY21
D	VAL22
D	GLY23
D	LYS24
D	SER25
D	CYS26
D	TYR36
D	ASN124
D	LYS125
D	ASP127
D	LEU128
D	SER154
D	ALA155
D	LYS156
D	AF3201
D	MG203
D	HOH302

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 203

Chain	Residue
D	SER25
D	THR43
D	AF3201
D	GDP202
D	HOH301
D	HOH302

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AF3 F 201

Chain	Residue
E	ARG188
E	GLN280
E	HOH501
F	SER20
F	GLY21
F	LYS24
F	THR43
F	THR67
F	GLY69
F	GDP202
F	MG203

---

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP F 202

Chain	Residue
F	TYR36
F	ASN124
F	LYS125
F	ASP127
F	LEU128
F	SER154
F	ALA155
F	LYS156
F	AF3201
F	MG203
F	HOH302
E	ARG188
E	ARG191
F	ASP19
F	GLY21
F	VAL22
F	GLY23
F	LYS24
F	SER25
F	CYS26

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 203

Chain	Residue
F	SER25
F	THR43
F	AF3201
F	GDP202
F	HOH301
F	HOH302

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKscL

Chain	Residue	Details
B	LEU14-LEU27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	273
Details	Region: {"description":"Tubulin-binding domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	51
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22939626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23588383","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23821544","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB1A in complex with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2FOL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FME","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JVS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22939626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23588383","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23821544","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB1A in complex with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FME","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IRU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JVS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22416225","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22939626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23588383","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB1A in complex with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"3TKL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FMD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FME","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JVS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"(Microbial infection) O-(2-cholinephosphoryl)serine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22158903","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32504010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	9
Details	Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32504010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32974215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P51153","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---