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4FL2

Structural and Biophysical Characterization of the Syk Activation Switch

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001775biological_processcell activation
A0001784molecular_functionphosphotyrosine residue binding
A0001819biological_processpositive regulation of cytokine production
A0001820biological_processserotonin secretion
A0001945biological_processlymph vessel development
A0002092biological_processpositive regulation of receptor internalization
A0002223biological_processstimulatory C-type lectin receptor signaling pathway
A0002250biological_processadaptive immune response
A0002281biological_processmacrophage activation involved in immune response
A0002283biological_processneutrophil activation involved in immune response
A0002366biological_processleukocyte activation involved in immune response
A0002554biological_processserotonin secretion by platelet
A0002684biological_processpositive regulation of immune system process
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005102molecular_functionsignaling receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006606biological_processprotein import into nucleus
A0007159biological_processleukocyte cell-cell adhesion
A0007166biological_processcell surface receptor signaling pathway
A0007167biological_processenzyme-linked receptor protein signaling pathway
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0009887biological_processanimal organ morphogenesis
A0010543biological_processregulation of platelet activation
A0010803biological_processregulation of tumor necrosis factor-mediated signaling pathway
A0016170molecular_functioninterleukin-15 receptor binding
A0016301molecular_functionkinase activity
A0018108biological_processpeptidyl-tyrosine phosphorylation
A0019370biological_processleukotriene biosynthetic process
A0019722biological_processcalcium-mediated signaling
A0019815cellular_componentB cell receptor complex
A0019901molecular_functionprotein kinase binding
A0019902molecular_functionphosphatase binding
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0030183biological_processB cell differentiation
A0030593biological_processneutrophil chemotaxis
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031623biological_processreceptor internalization
A0032009cellular_componentearly phagosome
A0032481biological_processpositive regulation of type I interferon production
A0032725biological_processpositive regulation of granulocyte macrophage colony-stimulating factor production
A0032733biological_processpositive regulation of interleukin-10 production
A0032735biological_processpositive regulation of interleukin-12 production
A0032752biological_processpositive regulation of interleukin-3 production
A0032753biological_processpositive regulation of interleukin-4 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032757biological_processpositive regulation of interleukin-8 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032765biological_processpositive regulation of mast cell cytokine production
A0032928biological_processregulation of superoxide anion generation
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035325molecular_functionToll-like receptor binding
A0035556biological_processintracellular signal transduction
A0038063biological_processcollagen-activated tyrosine kinase receptor signaling pathway
A0038095biological_processFc-epsilon receptor signaling pathway
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038156biological_processinterleukin-3-mediated signaling pathway
A0042101cellular_componentT cell receptor complex
A0042169molecular_functionSH2 domain binding
A0042492biological_processgamma-delta T cell differentiation
A0042742biological_processdefense response to bacterium
A0043274molecular_functionphospholipase binding
A0043280biological_processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043303biological_processmast cell degranulation
A0043306biological_processpositive regulation of mast cell degranulation
A0043313biological_processregulation of neutrophil degranulation
A0043366biological_processbeta selection
A0043410biological_processpositive regulation of MAPK cascade
A0045087biological_processinnate immune response
A0045579biological_processpositive regulation of B cell differentiation
A0045588biological_processpositive regulation of gamma-delta T cell differentiation
A0045780biological_processpositive regulation of bone resorption
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046641biological_processpositive regulation of alpha-beta T cell proliferation
A0048514biological_processblood vessel morphogenesis
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050764biological_processregulation of phagocytosis
A0050776biological_processregulation of immune response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050853biological_processB cell receptor signaling pathway
A0051090biological_processregulation of DNA-binding transcription factor activity
A0051649biological_processestablishment of localization in cell
A0051712biological_processpositive regulation of killing of cells of another organism
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0071226biological_processcellular response to molecule of fungal origin
A0071396biological_processcellular response to lipid
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071639biological_processpositive regulation of monocyte chemotactic protein-1 production
A0090237biological_processregulation of arachidonic acid secretion
A0090330biological_processregulation of platelet aggregation
A0097110molecular_functionscaffold protein binding
A0097242biological_processamyloid-beta clearance
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1904263biological_processpositive regulation of TORC1 signaling
A1904646biological_processcellular response to amyloid-beta
A1990858biological_processcellular response to lectin
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 701
ChainResidue
AASN499
AASP512
AANP702
AHOH874
AHOH897

site_idAC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE ANP A 702
ChainResidue
AGLY383
AVAL385
AALA400
ALYS402
AVAL433
AGLU449
AMET450
AALA451
APRO455
AARG498
AASN499
ALEU501
AASP512
ATYR525
ALYS533
AMG701
AHOH801
AHOH807
AHOH831
AHOH846
AHOH874
AHOH897
AHOH937
ASER379
AGLY380
AASN381
APHE382

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues26
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGNFGTVKkGyyqmkkvvkt........VAVK
ChainResidueDetails
ALEU377-LYS402

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNVLL
ChainResidueDetails
APHE490-LEU502

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP494

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU377
ALYS402

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21469132, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR28

site_idSWS_FT_FI4
Number of Residues9
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:21469132
ChainResidueDetails
ASER44
ASER202
ASER295
ASER297
ASER316
ASER319
ASER350
ASER379
ASER579

site_idSWS_FT_FI5
Number of Residues11
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21469132
ChainResidueDetails
ATYR47
ATYR629
ATYR631
ATYR131
ATYR296
ATYR348
ATYR352
ATYR364
ATYR484
ATYR507
ATYR526

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:21469132
ChainResidueDetails
ATHR256
ATHR317
ATHR345
ATHR384
ATHR530
ATHR582

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by LYN => ECO:0000269|PubMed:21469132, ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR323

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:21469132
ChainResidueDetails
ATYR525

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P48025
ChainResidueDetails
ATYR546

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18369315, ECO:0000269|PubMed:21469132
ChainResidueDetails
ATYR630

223166

PDB entries from 2024-07-31

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