4FKX
Crystal structure of nucleoside diphosphate kinase B from Trypanosoma brucei bound to CDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0006228 | biological_process | UTP biosynthetic process |
| A | 0006241 | biological_process | CTP biosynthetic process |
| A | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| A | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| A | 0016301 | molecular_function | kinase activity |
| A | 0097014 | cellular_component | ciliary plasm |
| B | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0006228 | biological_process | UTP biosynthetic process |
| B | 0006241 | biological_process | CTP biosynthetic process |
| B | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| B | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| B | 0016301 | molecular_function | kinase activity |
| B | 0097014 | cellular_component | ciliary plasm |
| C | 0004550 | molecular_function | nucleoside diphosphate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0006228 | biological_process | UTP biosynthetic process |
| C | 0006241 | biological_process | CTP biosynthetic process |
| C | 0009142 | biological_process | nucleoside triphosphate biosynthetic process |
| C | 0010608 | biological_process | post-transcriptional regulation of gene expression |
| C | 0016301 | molecular_function | kinase activity |
| C | 0097014 | cellular_component | ciliary plasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE CDP A 201 |
| Chain | Residue |
| A | LYS11 |
| A | ASN114 |
| A | MG202 |
| A | HOH340 |
| A | HOH392 |
| A | HOH393 |
| A | HOH394 |
| A | HOH395 |
| A | HOH396 |
| A | HOH437 |
| A | HOH457 |
| A | TYR51 |
| A | LEU54 |
| A | PHE59 |
| A | LEU63 |
| A | ARG87 |
| A | THR93 |
| A | VAL111 |
| A | GLY112 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | CDP201 |
| A | HOH392 |
| A | HOH393 |
| A | HOH394 |
| A | HOH395 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE CDP B 201 |
| Chain | Residue |
| B | LYS11 |
| B | TYR51 |
| B | LEU54 |
| B | PHE59 |
| B | LEU63 |
| B | ARG87 |
| B | THR93 |
| B | VAL111 |
| B | GLY112 |
| B | ASN114 |
| B | MG202 |
| B | HOH327 |
| B | HOH358 |
| B | HOH364 |
| B | HOH380 |
| B | HOH390 |
| B | HOH397 |
| B | HOH398 |
| B | HOH399 |
| B | HOH416 |
| B | HOH437 |
| B | HOH458 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | CDP201 |
| B | HOH364 |
| B | HOH397 |
| B | HOH398 |
| B | HOH399 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD B 203 |
| Chain | Residue |
| B | GLN49 |
| B | HIS50 |
| B | ILE52 |
| B | GLU128 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE CDP C 201 |
| Chain | Residue |
| C | LYS11 |
| C | LEU54 |
| C | PHE59 |
| C | LEU63 |
| C | ARG87 |
| C | THR93 |
| C | VAL111 |
| C | ASN114 |
| C | MG202 |
| C | HOH316 |
| C | HOH324 |
| C | HOH389 |
| C | HOH414 |
| C | HOH415 |
| C | HOH416 |
| C | HOH417 |
| C | HOH418 |
| C | HOH419 |
| C | HOH433 |
| C | HOH437 |
| C | HOH450 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 202 |
| Chain | Residue |
| C | CDP201 |
| C | HOH414 |
| C | HOH415 |
| C | HOH416 |
| C | HOH417 |
Functional Information from PROSITE/UniProt
| site_id | PS00469 |
| Number of Residues | 9 |
| Details | NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV |
| Chain | Residue | Details |
| A | ASN114-VAL122 |
