4FKK
Crystal structure of porcine aminopeptidase-N complexed with bestatin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0030154 | biological_process | cell differentiation |
| A | 0042277 | molecular_function | peptide binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHELAHQW |
| Chain | Residue | Details |
| A | VAL380-TRP389 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095 |
| Chain | Residue | Details |
| A | GLU384 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P15144 |
| Chain | Residue | Details |
| A | GLY347 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C |
| Chain | Residue | Details |
| A | HIS387 | |
| A | GLU406 | |
| A | HIS383 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144 |
| Chain | Residue | Details |
| A | TYR472 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Sulfotyrosine => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22876187, ECO:0007744|PDB:4F5C |
| Chain | Residue | Details |
| A | ASN314 | |
| A | ASN328 | |
| A | ASN506 | |
| A | ASN622 | |
| A | ASN646 | |
| A | ASN736 | |
| A | ASN82 | |
| A | ASN124 | |
| A | ASN229 | |
| A | ASN237 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN258 | |
| A | ASN286 | |
| A | ASN556 | |
| A | ASN569 |
