4FFS
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Helicobacter pylori with butyl-thio-DADMe-Immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| A | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE BIG A 301 |
| Chain | Residue |
| A | ALA9 |
| A | VAL172 |
| A | GLU173 |
| A | MET174 |
| A | GLU175 |
| A | SER197 |
| A | ASP198 |
| A | PHE208 |
| A | HOH565 |
| A | MET10 |
| A | ILE52 |
| A | VAL78 |
| A | ALA79 |
| A | GLY80 |
| A | LEU104 |
| A | PHE153 |
| A | VAL154 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 302 |
| Chain | Residue |
| A | VAL23 |
| A | ASP24 |
| A | LYS185 |
| A | HOH409 |
| A | HOH607 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:20954236 |
| Chain | Residue | Details |
| A | GLU13 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:20954236 |
| Chain | Residue | Details |
| A | ASP198 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY80 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | VAL154 | |
| A | MET174 |
