Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0047112 | molecular_function | pyruvate oxidase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0047112 | molecular_function | pyruvate oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR A 701 |
| Chain | Residue |
| A | LEU555 |
| A | ARG556 |
| A | LEU557 |
| A | ASP558 |
| A | MET561 |
| A | SER562 |
| A | HOH977 |
| A | HOH1633 |
| A | HOH1687 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR A 702 |
| Chain | Residue |
| A | PHE121 |
| A | ASN263 |
| A | ARG264 |
| A | FAD709 |
| A | HOH1258 |
| A | HOH1488 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 A 703 |
| Chain | Residue |
| A | GLY34 |
| A | GLY35 |
| A | SER36 |
| A | SER82 |
| A | PHE111 |
| A | GLN122 |
| A | ILE480 |
| A | TDM708 |
| A | HOH909 |
| A | HOH956 |
| A | HOH1679 |
| A | HOH1766 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 704 |
| Chain | Residue |
| A | TRP24 |
| A | LYS75 |
| A | TYR158 |
| A | TYR189 |
| A | HOH1032 |
| A | HOH1684 |
| B | HOH7778 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 705 |
| Chain | Residue |
| A | LYS433 |
| A | PRO437 |
| A | GLU438 |
| A | PRO466 |
| A | ALA533 |
| A | GLN534 |
| A | HOH1047 |
| A | HOH1225 |
| A | HOH1483 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 706 |
| Chain | Residue |
| A | ARG156 |
| A | HIS160 |
| A | HOH849 |
| A | HOH894 |
| A | HOH1701 |
| B | ASN286 |
| B | LYS311 |
| B | LYS314 |
| B | HOH7143 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 707 |
| Chain | Residue |
| A | ASP447 |
| A | ASN474 |
| A | GLN476 |
| A | TDM708 |
| A | HOH1632 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TDM A 708 |
| Chain | Residue |
| A | PRO33 |
| A | GLU59 |
| A | SER82 |
| A | PRO85 |
| A | HIS89 |
| A | GLN122 |
| A | VAL394 |
| A | ASP396 |
| A | ALA420 |
| A | MET422 |
| A | GLY446 |
| A | ASP447 |
| A | GLY448 |
| A | GLY449 |
| A | ASN474 |
| A | GLN476 |
| A | TYR477 |
| A | GLY478 |
| A | PHE479 |
| A | ILE480 |
| A | PO4703 |
| A | MG707 |
| A | FAD709 |
| A | HOH813 |
| A | HOH822 |
| A | HOH847 |
| A | HOH1632 |
| site_id | AC9 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A 709 |
| Chain | Residue |
| A | PHE289 |
| A | ASP306 |
| A | ILE307 |
| A | ASP308 |
| A | LYS311 |
| A | ALA324 |
| A | ASP325 |
| A | ALA326 |
| A | ASN398 |
| A | SER416 |
| A | ASN417 |
| A | PYR702 |
| A | TDM708 |
| A | HOH802 |
| A | HOH805 |
| A | HOH806 |
| A | HOH835 |
| A | HOH1350 |
| A | HOH1423 |
| A | HOH1642 |
| A | HIS101 |
| A | PHE121 |
| A | GLY220 |
| A | ILE221 |
| A | GLY222 |
| A | THR244 |
| A | TYR245 |
| A | ALA262 |
| A | ASN263 |
| A | ARG264 |
| A | VAL265 |
| A | GLY284 |
| A | ASN285 |
| A | ASN286 |
| A | PRO288 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 710 |
| Chain | Residue |
| A | TRP174 |
| A | THR487 |
| A | GLN489 |
| A | HOH978 |
| A | HOH1268 |
| A | HOH1630 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR B 701 |
| Chain | Residue |
| B | LEU555 |
| B | ARG556 |
| B | LEU557 |
| B | ASP558 |
| B | MET561 |
| B | SER562 |
| B | HOH7219 |
| B | HOH7320 |
| B | HOH7670 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR B 702 |
| Chain | Residue |
| B | PHE121 |
| B | ASN263 |
| B | ARG264 |
| B | FAD710 |
| B | HOH7316 |
| B | HOH7680 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 B 703 |
| Chain | Residue |
| B | GLY34 |
| B | GLY35 |
| B | SER36 |
| B | SER82 |
| B | PHE111 |
| B | GLN122 |
| B | ILE480 |
| B | TDM709 |
| B | HOH7057 |
| B | HOH7131 |
| B | HOH7828 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL B 704 |
| Chain | Residue |
| B | GLY25 |
| B | ASP27 |
| B | HIS28 |
| B | ASP69 |
| B | THR73 |
| B | LYS75 |
| B | ILE76 |
| B | ASN435 |
| B | HOH7034 |
| B | HOH7615 |
| B | HOH7802 |
| B | HOH7835 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 705 |
| Chain | Residue |
| A | HOH1012 |
| B | ALA569 |
| B | PHE570 |
| B | ARG573 |
| B | TYR574 |
| B | HOH7137 |
| B | HOH7144 |
| B | HOH7887 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 706 |
| Chain | Residue |
| B | LYS433 |
| B | PRO437 |
| B | GLU438 |
| B | PRO466 |
| B | ALA533 |
| B | GLN534 |
| B | HOH7346 |
| B | HOH7638 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 707 |
| Chain | Residue |
| B | PRO409 |
| B | ARG412 |
| B | HOH7114 |
| B | HOH7178 |
| B | HOH7395 |
| B | HOH7575 |
| B | HOH7792 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 708 |
| Chain | Residue |
| B | ASP447 |
| B | ASN474 |
| B | GLN476 |
| B | TDM709 |
| B | HOH7798 |
| site_id | CC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TDM B 709 |
| Chain | Residue |
| B | PRO33 |
| B | GLU59 |
| B | SER82 |
| B | PRO85 |
| B | HIS89 |
| B | GLN122 |
| B | VAL394 |
| B | ASP396 |
| B | ALA420 |
| B | MET422 |
| B | GLY446 |
| B | ASP447 |
| B | GLY448 |
| B | GLY449 |
| B | ASN474 |
| B | GLN476 |
| B | TYR477 |
| B | GLY478 |
| B | PHE479 |
| B | ILE480 |
| B | PO4703 |
| B | MG708 |
| B | FAD710 |
| B | HOH7010 |
| B | HOH7023 |
| B | HOH7045 |
| B | HOH7798 |
| site_id | CC2 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 710 |
| Chain | Residue |
| B | HIS101 |
| B | PHE121 |
| B | GLY220 |
| B | ILE221 |
| B | GLY222 |
| B | THR244 |
| B | TYR245 |
| B | PRO246 |
| B | ALA262 |
| B | ASN263 |
| B | ARG264 |
| B | VAL265 |
| B | GLY284 |
| B | ASN285 |
| B | ASN286 |
| B | TYR287 |
| B | PRO288 |
| B | PHE289 |
| B | ASP306 |
| B | ILE307 |
| B | ASP308 |
| B | LYS311 |
| B | ALA324 |
| B | ASP325 |
| B | ALA326 |
| B | ASN398 |
| B | SER416 |
| B | ASN417 |
| B | PYR702 |
| B | TDM709 |
| B | HOH7001 |
| B | HOH7003 |
| B | HOH7015 |
| B | HOH7019 |
| B | HOH7611 |
| B | HOH7675 |
| B | HOH7739 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IAaklnyPerqvFnLaGDGG |
| Chain | Residue | Details |
| A | ILE430-GLY449 | |
