4FDJ
The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003943 | molecular_function | N-acetylgalactosamine-4-sulfatase activity |
| A | 0004065 | molecular_function | arylsulfatase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043890 | molecular_function | N-acetylgalactosamine-6-sulfatase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003943 | molecular_function | N-acetylgalactosamine-4-sulfatase activity |
| B | 0004065 | molecular_function | arylsulfatase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0043890 | molecular_function | N-acetylgalactosamine-6-sulfatase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 11 |
| Details | SULFATASE_2 Sulfatases signature 2. GYvSkiVGK.WH |
| Chain | Residue | Details |
| A | GLY132-HIS142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | DDZ79 | |
| B | DDZ79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P15289 |
| Chain | Residue | Details |
| A | HIS142 | |
| B | HIS142 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | ASP39 | |
| A | ASP40 | |
| A | ASP288 | |
| A | ASN289 | |
| B | ASP39 | |
| B | ASP40 | |
| B | ASP288 | |
| B | ASN289 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: via 3-oxoalanine => ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | DDZ79 | |
| B | DDZ79 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: 3-oxoalanine (Cys) => ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | DDZ79 | |
| B | DDZ79 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | ASN204 | |
| B | ASN204 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22940367 |
| Chain | Residue | Details |
| A | ASN423 | |
| B | ASN423 |
