4FD3

Crystal structure of apo-formed ymtOAR1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0005739	cellular_component	mitochondrion
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009060	biological_process	aerobic respiration
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0048038	molecular_function	quinone binding
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0005739	cellular_component	mitochondrion
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0009060	biological_process	aerobic respiration
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0048038	molecular_function	quinone binding
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0005739	cellular_component	mitochondrion
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0009060	biological_process	aerobic respiration
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0048038	molecular_function	quinone binding
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0005739	cellular_component	mitochondrion
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0009060	biological_process	aerobic respiration
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0048038	molecular_function	quinone binding
E	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0005739	cellular_component	mitochondrion
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0009060	biological_process	aerobic respiration
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0048038	molecular_function	quinone binding
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0005739	cellular_component	mitochondrion
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0009060	biological_process	aerobic respiration
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0048038	molecular_function	quinone binding

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. LhsgkmkvpgTsvYSASKAALsRFTeVLA

Chain	Residue	Details
A	LEU185-ALA213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	SER182
B	SER182
C	SER182
D	SER182
E	SER182
F	SER182

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR198
B	TYR198
C	TYR198
D	TYR198
E	TYR198
F	TYR198

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	ACT_SITE: Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	LYS202
B	LYS202
C	LYS202
D	LYS202
E	LYS202
F	LYS202

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	BINDING: BINDING => ECO:0007744|PDB:4FDA, ECO:0007744|PDB:4HBG

Chain	Residue	Details
A	THR13
B	ARG14
B	SER36
B	SER40
B	ASP66
B	PHE67
B	GLY122
B	TYR198
C	THR13
C	ARG14
C	SER36
A	ARG14
C	SER40
C	ASP66
C	PHE67
C	GLY122
C	TYR198
D	THR13
D	ARG14
D	SER36
D	SER40
D	ASP66
A	SER36
D	PHE67
D	GLY122
D	TYR198
E	THR13
E	ARG14
E	SER36
E	SER40
E	ASP66
E	PHE67
E	GLY122
A	SER40
E	TYR198
F	THR13
F	ARG14
F	SER36
F	SER40
F	ASP66
F	PHE67
F	GLY122
F	TYR198
A	ASP66
A	PHE67
A	GLY122
A	TYR198
B	THR13

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	BINDING: BINDING => ECO:0007744|PDB:4HBG

Chain	Residue	Details
A	ILE16
D	ILE16
D	LYS202
D	LEU230
E	ILE16
E	LYS202
E	LEU230
F	ILE16
F	LYS202
F	LEU230
A	LYS202
A	LEU230
B	ILE16
B	LYS202
B	LEU230
C	ILE16
C	LYS202
C	LEU230

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:L0E2Z4

Chain	Residue	Details
A	THR44
E	GLU77
F	THR44
F	GLU77
A	GLU77
B	THR44
B	GLU77
C	THR44
C	GLU77
D	THR44
D	GLU77
E	THR44

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:4FDA

Chain	Residue	Details
A	GLN125
E	GLU126
F	GLN125
F	GLU126
A	GLU126
B	GLN125
B	GLU126
C	GLN125
C	GLU126
D	GLN125
D	GLU126
E	GLN125

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	VAL231
B	VAL231
C	VAL231
D	VAL231
E	VAL231
F	VAL231

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