4FBW
Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030870 | cellular_component | Mre11 complex |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006302 | biological_process | double-strand break repair |
| B | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030870 | cellular_component | Mre11 complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 501 |
| Chain | Residue |
| A | ASP65 |
| A | ASN133 |
| A | HIS222 |
| A | HIS250 |
| A | MN502 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 502 |
| Chain | Residue |
| A | MN501 |
| A | ASP25 |
| A | HIS27 |
| A | ASP65 |
| A | HIS252 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 501 |
| Chain | Residue |
| B | ASP65 |
| B | ASN133 |
| B | HIS222 |
| B | HIS250 |
| B | MN502 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 502 |
| Chain | Residue |
| B | ASP25 |
| B | HIS27 |
| B | ASP65 |
| B | HIS252 |
| B | MN501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PIRSR","id":"PIRSR000882-1","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22705791","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FBQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FCX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
