4FBP

CONFORMATIONAL TRANSITION OF FRUCTOSE-1,6-BISPHOSPHATASE: STRUCTURE COMPARISON BETWEEN THE AMP COMPLEX (T FORM) AND THE FRUCTOSE 6-PHOSPHATE COMPLEX (R FORM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003824	molecular_function	catalytic activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006111	biological_process	regulation of gluconeogenesis
A	0016208	molecular_function	AMP binding
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045820	biological_process	negative regulation of glycolytic process
A	0046580	biological_process	negative regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0071286	biological_process	cellular response to magnesium ion
A	0071466	biological_process	cellular response to xenobiotic stimulus
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003824	molecular_function	catalytic activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0006002	biological_process	fructose 6-phosphate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006111	biological_process	regulation of gluconeogenesis
B	0016208	molecular_function	AMP binding
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030308	biological_process	negative regulation of cell growth
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0045820	biological_process	negative regulation of glycolytic process
B	0046580	biological_process	negative regulation of Ras protein signal transduction
B	0046872	molecular_function	metal ion binding
B	0048029	molecular_function	monosaccharide binding
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0071286	biological_process	cellular response to magnesium ion
B	0071466	biological_process	cellular response to xenobiotic stimulus
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0003824	molecular_function	catalytic activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006000	biological_process	fructose metabolic process
C	0006002	biological_process	fructose 6-phosphate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006111	biological_process	regulation of gluconeogenesis
C	0016208	molecular_function	AMP binding
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030308	biological_process	negative regulation of cell growth
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0045820	biological_process	negative regulation of glycolytic process
C	0046580	biological_process	negative regulation of Ras protein signal transduction
C	0046872	molecular_function	metal ion binding
C	0048029	molecular_function	monosaccharide binding
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0071286	biological_process	cellular response to magnesium ion
C	0071466	biological_process	cellular response to xenobiotic stimulus
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003824	molecular_function	catalytic activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006111	biological_process	regulation of gluconeogenesis
D	0016208	molecular_function	AMP binding
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030308	biological_process	negative regulation of cell growth
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045820	biological_process	negative regulation of glycolytic process
D	0046580	biological_process	negative regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0071286	biological_process	cellular response to magnesium ion
D	0071466	biological_process	cellular response to xenobiotic stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP A 338

Chain	Residue
A	VAL17
A	LYS112
A	TYR113
A	ARG140
A	VAL160
A	MET177
A	HOH628
A	GLN20
A	GLY21
A	ALA24
A	GLY26
A	THR27
A	GLU29
A	MET30
A	THR31

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP B 338

Chain	Residue
B	VAL17
B	GLN20
B	GLY21
B	ALA24
B	GLY26
B	THR27
B	GLY28
B	GLU29
B	MET30
B	THR31
B	LYS112
B	TYR113
B	ARG140
B	MET177
B	HOH465
C	HOH409

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AMP C 338

Chain	Residue
D	VAL17
D	GLN20
D	GLY21
D	THR27
D	GLY28
D	GLU29
D	MET30
D	THR31
D	LYS112
D	TYR113

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP D 338

Chain	Residue
C	VAL17
C	GLN20
C	GLY21
C	GLY26
C	THR27
C	GLY28
C	GLU29
C	MET30
C	THR31
C	LYS112
C	TYR113
C	ARG140
C	VAL160
C	MET177
D	HOH543

---

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA

Chain	Residue	Details
A	GLY273-ALA285

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12595528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1312721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14530289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17933867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1849642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2157849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12595528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1312721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14530289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17933867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1849642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2157849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12595528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1312721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14530289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17933867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1849642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2157849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12595528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1312721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14530289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17933867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1849642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2157849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10913263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12595528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1312721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14530289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15767255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17933867","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1849642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2157849","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2164670","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1EYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FBP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FJ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FSA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KZ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LEV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YXI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2F3D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H45","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"6296821","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P09467","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA2
Number of Residues	7
Details	M-CSA 546

Chain	Residue	Details
B	ASP74	electrostatic stabiliser, proton acceptor, proton donor
B	GLU97	metal ligand
B	GLU98	electrostatic stabiliser
B	ASP118	metal ligand
B	LEU120	metal ligand
B	ASP121	metal ligand
B	GLU280	metal ligand

---

site_id	MCSA3
Number of Residues	7
Details	M-CSA 546

Chain	Residue	Details
C	ASP74	electrostatic stabiliser, proton acceptor, proton donor
C	GLU97	metal ligand
C	GLU98	electrostatic stabiliser
C	ASP118	metal ligand
C	LEU120	metal ligand
C	ASP121	metal ligand
C	GLU280	metal ligand

---

site_id	MCSA4
Number of Residues	7
Details	M-CSA 546

Chain	Residue	Details
D	ASP74	electrostatic stabiliser, proton acceptor, proton donor
D	GLU97	metal ligand
D	GLU98	electrostatic stabiliser
D	ASP118	metal ligand
D	LEU120	metal ligand
D	ASP121	metal ligand
D	GLU280	metal ligand

---

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
A	GLU98
A	ASP74

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
B	GLU98
B	ASP74

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
C	GLU98
C	ASP74

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eyi

Chain	Residue	Details
D	GLU98
D	ASP74

---

site_id	MCSA1
Number of Residues	7
Details	M-CSA 546

Chain	Residue	Details
A	ASP74	electrostatic stabiliser, proton acceptor, proton donor
A	GLU97	metal ligand
A	GLU98	electrostatic stabiliser
A	ASP118	metal ligand
A	LEU120	metal ligand
A	ASP121	metal ligand
A	GLU280	metal ligand

---