Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F8H

X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RKE A 401

Chain	Residue
A	TYR23
A	ASN152
A	ASP153
A	ASP154
B	PHE174
B	LEU176
B	LYS183

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LMD A 402

Chain	Residue
A	ILE233
A	ALA237
A	ILE240
A	THR244
A	ASN245
B	THR244
B	LMD402
C	LMD405
E	ILE233
E	ALA234
E	ALA237
E	LMD402
A	ASP31
A	LYS33

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 A 403

Chain	Residue
A	PHE121
A	TYR194
A	TYR254
A	ASN307
A	PHE315

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 A 404

Chain	Residue
A	ARG118
A	MET252
A	MET261
A	LEU313
A	PHE314

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RKE B 401

Chain	Residue
B	TYR23
B	ASN152
B	ASP153
B	ASP154
C	VAL79
C	PHE174
C	LEU176
C	LYS183

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LMD B 402

Chain	Residue
A	ALA234
A	ALA237
A	LMD402
B	ASP31
B	LYS33
B	ILE233
B	ALA237
B	LEU241
B	THR244
B	ASN245
B	HOH507
C	LYS33
C	THR244
C	LMD402
C	LMD405

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 B 403

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	TYR254
B	ASN307
B	PHE315
B	PC1404

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PC1 B 404

Chain	Residue
B	ARG118
B	LEU313
B	PC1403

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RKE C 401

Chain	Residue
C	TYR23
C	ASN152
C	ASP153
C	ASP154
D	VAL79
D	PHE174
D	LEU176
D	LYS183

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMD C 402

Chain	Residue
B	ILE233
B	ALA234
B	ALA237
B	LMD402
C	ASP31
C	ILE233
C	THR244
C	ASN245
C	LMD405
D	LYS33
D	LMD402

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PC1 C 403

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	ILE198
C	LEU206
C	TYR254
C	ASN307
C	PHE315

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 C 404

Chain	Residue
B	PHE195
C	TYR251
C	MET252
C	MET261
C	LEU264

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMD C 405

Chain	Residue
B	LMD402
C	SER230
C	ILE233
C	LMD402
D	ILE233
D	LMD402
E	SER230
E	ILE233
E	LMD402
A	ILE233
A	LMD402
B	ILE233

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RKE D 401

Chain	Residue
D	TYR23
D	ASN152
D	ASP153
D	ASP154
E	PHE174
E	LEU176
E	LYS183

site_id	BC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LMD D 402

Chain	Residue
C	ALA234
C	ALA237
C	LMD402
C	LMD405
D	ASP31
D	ILE236
D	ALA237
D	ILE240
D	THR244
D	ASN245
E	LYS33
E	THR244
E	LMD402

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PC1 D 403

Chain	Residue
D	ARG118
D	TYR194
D	ILE198
D	TYR254
D	ASN307
D	PHE315

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 D 404

Chain	Residue
C	PHE195
D	ARG118
D	MET252
D	PHE260
D	LEU313

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RKE E 401

Chain	Residue
A	VAL79
A	PHE174
A	LEU176
A	LYS183
E	TYR23
E	ASN152
E	ASP153
E	ASP154

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LMD E 402

Chain	Residue
A	LYS33
A	THR244
A	LMD402
C	LMD405
D	ILE233
D	LMD402
E	ASP31
E	ILE233
E	ALA237
E	ILE240
E	THR244
E	ASN245

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 E 403

Chain	Residue
E	PHE121
E	GLU163
E	SER191
E	TYR194
E	TYR254
E	ASN307
E	PHE315

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 E 404

Chain	Residue
E	ARG118
E	TYR251
E	MET252
E	LEU313
E	PHE314

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)