4F8C

Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006508	biological_process	proteolysis
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008104	biological_process	protein localization
B	0009653	biological_process	anatomical structure morphogenesis
B	0016567	biological_process	protein ubiquitination
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030162	biological_process	regulation of proteolysis
B	0031386	molecular_function	protein tag activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0036211	biological_process	protein modification process
B	0045116	biological_process	protein neddylation
B	0070062	cellular_component	extracellular exosome
B	0072757	biological_process	cellular response to camptothecin
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0008104	biological_process	protein localization
D	0009653	biological_process	anatomical structure morphogenesis
D	0016567	biological_process	protein ubiquitination
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030162	biological_process	regulation of proteolysis
D	0031386	molecular_function	protein tag activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0036211	biological_process	protein modification process
D	0045116	biological_process	protein neddylation
D	0070062	cellular_component	extracellular exosome
D	0072757	biological_process	cellular response to camptothecin
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0150052	biological_process	regulation of postsynapse assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	LEU57
A	ASN60
A	VAL61
A	SER108
A	SER109
A	ARG111
A	HOH510

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	ILE235
A	ASP236
A	HIS239
A	ILE240
A	HIS226
A	GLY229

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 301

Chain	Residue
C	THR225
C	HIS226
C	ILE235
C	ASP236
C	HIS239
C	ILE240

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 302

Chain	Residue
C	LEU57
C	ASN60
C	VAL61
C	SER108
C	ARG111
C	HOH530

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Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
B	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:19308257, ECO:0000305|PubMed:22691497

Chain	Residue	Details
A	ALA117
C	ALA117
D	LEU8
D	ILE44

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q63KH5

Chain	Residue	Details
A	HIS173
A	GLN193
C	HIS173
C	GLN193

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P29595

Chain	Residue	Details
B	LYS48
D	LYS48

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000269|PubMed:38316879

Chain	Residue	Details
B	GLY76
D	GLY76

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