4F86
Structure analysis of Geranyl diphosphate methyltransferase in complex with GPP and sinefungin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008169 | molecular_function | C-methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042214 | biological_process | terpene metabolic process |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008169 | molecular_function | C-methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0042214 | biological_process | terpene metabolic process |
| B | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0008169 | molecular_function | C-methyltransferase activity |
| C | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0032259 | biological_process | methylation |
| C | 0042214 | biological_process | terpene metabolic process |
| C | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0008169 | molecular_function | C-methyltransferase activity |
| D | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032259 | biological_process | methylation |
| D | 0042214 | biological_process | terpene metabolic process |
| D | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0008169 | molecular_function | C-methyltransferase activity |
| E | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0032259 | biological_process | methylation |
| E | 0042214 | biological_process | terpene metabolic process |
| E | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0008169 | molecular_function | C-methyltransferase activity |
| F | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0032259 | biological_process | methylation |
| F | 0042214 | biological_process | terpene metabolic process |
| F | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| G | 0000287 | molecular_function | magnesium ion binding |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0008169 | molecular_function | C-methyltransferase activity |
| G | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0032259 | biological_process | methylation |
| G | 0042214 | biological_process | terpene metabolic process |
| G | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| H | 0000287 | molecular_function | magnesium ion binding |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0008169 | molecular_function | C-methyltransferase activity |
| H | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0032259 | biological_process | methylation |
| H | 0042214 | biological_process | terpene metabolic process |
| H | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| I | 0000287 | molecular_function | magnesium ion binding |
| I | 0008168 | molecular_function | methyltransferase activity |
| I | 0008169 | molecular_function | C-methyltransferase activity |
| I | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| I | 0016740 | molecular_function | transferase activity |
| I | 0032259 | biological_process | methylation |
| I | 0042214 | biological_process | terpene metabolic process |
| I | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| J | 0000287 | molecular_function | magnesium ion binding |
| J | 0008168 | molecular_function | methyltransferase activity |
| J | 0008169 | molecular_function | C-methyltransferase activity |
| J | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| J | 0016740 | molecular_function | transferase activity |
| J | 0032259 | biological_process | methylation |
| J | 0042214 | biological_process | terpene metabolic process |
| J | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| K | 0000287 | molecular_function | magnesium ion binding |
| K | 0008168 | molecular_function | methyltransferase activity |
| K | 0008169 | molecular_function | C-methyltransferase activity |
| K | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| K | 0016740 | molecular_function | transferase activity |
| K | 0032259 | biological_process | methylation |
| K | 0042214 | biological_process | terpene metabolic process |
| K | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| L | 0000287 | molecular_function | magnesium ion binding |
| L | 0008168 | molecular_function | methyltransferase activity |
| L | 0008169 | molecular_function | C-methyltransferase activity |
| L | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| L | 0016740 | molecular_function | transferase activity |
| L | 0032259 | biological_process | methylation |
| L | 0042214 | biological_process | terpene metabolic process |
| L | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG A 501 |
| Chain | Residue |
| A | GLN30 |
| A | GLN140 |
| A | CYS162 |
| A | ASN163 |
| A | MET164 |
| A | ASN180 |
| A | GLU181 |
| A | SER182 |
| A | TYR185 |
| A | VAL186 |
| A | GPP502 |
| A | HIS57 |
| A | HIS58 |
| A | GLY113 |
| A | CYS114 |
| A | GLY115 |
| A | SER119 |
| A | THR135 |
| A | LEU136 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GPP A 502 |
| Chain | Residue |
| A | TRP37 |
| A | ARG42 |
| A | VAL44 |
| A | ASN45 |
| A | HIS57 |
| A | TYR59 |
| A | GLU181 |
| A | MET184 |
| A | PHE230 |
| A | ARG268 |
| A | PHE281 |
| A | SFG501 |
| A | MG503 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 503 |
| Chain | Residue |
| A | VAL44 |
| A | ASN45 |
| A | HIS58 |
| A | GLU89 |
| A | GPP502 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SFG B 501 |
| Chain | Residue |
| B | GLN30 |
| B | TRP37 |
| B | HIS57 |
| B | HIS58 |
| B | ASP111 |
| B | GLY113 |
| B | CYS114 |
| B | GLY115 |
| B | SER119 |
| B | THR135 |
| B | LEU136 |
| B | GLN140 |
| B | CYS162 |
| B | ASN163 |
| B | MET164 |
| B | ASN180 |
| B | GLU181 |
| B | SER182 |
| B | TYR185 |
| B | VAL186 |
| B | GPP502 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GPP B 502 |
| Chain | Residue |
| B | TRP37 |
| B | ARG42 |
| B | VAL44 |
| B | ASN45 |
| B | HIS57 |
| B | HIS58 |
| B | TYR59 |
| B | GLU181 |
| B | MET184 |
| B | PHE230 |
| B | ARG268 |
| B | SFG501 |
| B | MG503 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | ASN45 |
| B | HIS58 |
| B | GLU89 |
| B | GPP502 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SFG C 501 |
| Chain | Residue |
| C | TRP37 |
| C | HIS57 |
| C | HIS58 |
| C | GLY113 |
| C | CYS114 |
| C | GLY115 |
| C | THR135 |
| C | LEU136 |
| C | GLN140 |
| C | CYS162 |
| C | ASN163 |
| C | MET164 |
| C | ASN180 |
| C | GLU181 |
| C | SER182 |
| C | TYR185 |
| C | VAL186 |
| C | GPP502 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GPP C 502 |
| Chain | Residue |
| C | MET184 |
| C | TYR185 |
| C | GLY210 |
| C | PHE230 |
| C | ARG268 |
| C | THR275 |
| C | PHE281 |
| C | PHE290 |
| C | SFG501 |
| C | MG503 |
| C | ARG42 |
| C | VAL44 |
| C | ASN45 |
| C | HIS57 |
| C | HIS58 |
| C | TYR59 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 503 |
| Chain | Residue |
| C | ASN45 |
| C | HIS58 |
| C | GLU89 |
| C | TYR264 |
| C | GPP502 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SFG D 501 |
| Chain | Residue |
| D | GLN30 |
| D | TRP37 |
| D | HIS57 |
| D | HIS58 |
| D | GLY113 |
| D | GLY115 |
| D | THR135 |
| D | LEU136 |
| D | GLN140 |
| D | CYS162 |
| D | ASN163 |
| D | MET164 |
| D | ASN180 |
| D | GLU181 |
| D | SER182 |
| D | TYR185 |
| D | VAL186 |
| D | GPP502 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GPP D 502 |
| Chain | Residue |
| D | TRP37 |
| D | ARG42 |
| D | VAL44 |
| D | ASN45 |
| D | HIS57 |
| D | HIS58 |
| D | TYR59 |
| D | GLU181 |
| D | MET184 |
| D | TYR185 |
| D | PHE230 |
| D | ARG268 |
| D | PHE281 |
| D | SFG501 |
| D | MG503 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 503 |
| Chain | Residue |
| D | ASN45 |
| D | HIS58 |
| D | GLU89 |
| D | TYR264 |
| D | GPP502 |
| site_id | BC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG E 501 |
| Chain | Residue |
| E | GLN30 |
| E | ILE33 |
| E | TRP37 |
| E | HIS57 |
| E | HIS58 |
| E | GLY113 |
| E | GLY115 |
| E | THR135 |
| E | LEU136 |
| E | GLN140 |
| E | CYS162 |
| E | ASN163 |
| E | MET164 |
| E | ASN180 |
| E | GLU181 |
| E | SER182 |
| E | TYR185 |
| E | VAL186 |
| E | GPP502 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GPP E 502 |
| Chain | Residue |
| E | TRP37 |
| E | ARG42 |
| E | VAL44 |
| E | ASN45 |
| E | HIS57 |
| E | TYR59 |
| E | GLU181 |
| E | MET184 |
| E | TYR185 |
| E | PHE230 |
| E | ARG268 |
| E | SFG501 |
| E | MG503 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG E 503 |
| Chain | Residue |
| E | ASN45 |
| E | HIS58 |
| E | GLU89 |
| E | GPP502 |
| site_id | BC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG F 501 |
| Chain | Residue |
| F | TRP37 |
| F | TYR55 |
| F | HIS57 |
| F | HIS58 |
| F | GLY113 |
| F | CYS114 |
| F | GLY115 |
| F | SER119 |
| F | THR135 |
| F | LEU136 |
| F | GLN140 |
| F | CYS162 |
| F | ASN163 |
| F | MET164 |
| F | ASN180 |
| F | GLU181 |
| F | SER182 |
| F | TYR185 |
| F | GPP502 |
| site_id | BC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GPP F 502 |
| Chain | Residue |
| F | TRP37 |
| F | ARG42 |
| F | VAL44 |
| F | ASN45 |
| F | HIS57 |
| F | TYR59 |
| F | GLU181 |
| F | MET184 |
| F | TYR185 |
| F | GLY210 |
| F | ILE234 |
| F | ARG268 |
| F | PHE281 |
| F | PHE290 |
| F | SFG501 |
| F | MG503 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 503 |
| Chain | Residue |
| F | ASN45 |
| F | HIS58 |
| F | GLU89 |
| F | GPP502 |
| site_id | CC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG G 501 |
| Chain | Residue |
| G | ILE33 |
| G | TRP37 |
| G | HIS57 |
| G | HIS58 |
| G | GLY113 |
| G | CYS114 |
| G | GLY115 |
| G | THR135 |
| G | LEU136 |
| G | GLN140 |
| G | CYS162 |
| G | ASN163 |
| G | MET164 |
| G | ASN180 |
| G | GLU181 |
| G | SER182 |
| G | TYR185 |
| G | VAL186 |
| G | GPP502 |
| site_id | CC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GPP G 502 |
| Chain | Residue |
| G | TRP37 |
| G | ARG42 |
| G | VAL44 |
| G | ASN45 |
| G | HIS57 |
| G | TYR59 |
| G | GLU181 |
| G | MET184 |
| G | TYR185 |
| G | ILE226 |
| G | PHE230 |
| G | ARG268 |
| G | THR275 |
| G | PHE281 |
| G | SFG501 |
| G | MG503 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG G 503 |
| Chain | Residue |
| G | ASN45 |
| G | HIS58 |
| G | GLU89 |
| G | GPP502 |
| site_id | CC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG H 501 |
| Chain | Residue |
| H | TRP37 |
| H | HIS57 |
| H | HIS58 |
| H | GLY113 |
| H | CYS114 |
| H | GLY115 |
| H | SER119 |
| H | THR135 |
| H | LEU136 |
| H | GLN140 |
| H | CYS162 |
| H | ASN163 |
| H | MET164 |
| H | ASN180 |
| H | GLU181 |
| H | SER182 |
| H | TYR185 |
| H | VAL186 |
| H | GPP502 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GPP H 502 |
| Chain | Residue |
| H | TRP37 |
| H | ARG42 |
| H | HIS57 |
| H | TYR59 |
| H | GLU181 |
| H | MET184 |
| H | TYR185 |
| H | GLY210 |
| H | ARG268 |
| H | THR275 |
| H | PHE281 |
| H | SFG501 |
| H | MG503 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG H 503 |
| Chain | Residue |
| H | HIS58 |
| H | GLU89 |
| H | GPP502 |
| site_id | CC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SFG I 501 |
| Chain | Residue |
| I | GLN30 |
| I | TRP37 |
| I | HIS57 |
| I | HIS58 |
| I | GLY113 |
| I | CYS114 |
| I | GLY115 |
| I | THR135 |
| I | LEU136 |
| I | GLN140 |
| I | CYS162 |
| I | ASN163 |
| I | MET164 |
| I | ASN180 |
| I | GLU181 |
| I | SER182 |
| I | TYR185 |
| I | VAL186 |
| I | GPP502 |
| site_id | CC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GPP I 502 |
| Chain | Residue |
| I | ARG42 |
| I | VAL44 |
| I | ASN45 |
| I | HIS57 |
| I | HIS58 |
| I | TYR59 |
| I | GLU181 |
| I | MET184 |
| I | GLY210 |
| I | PHE230 |
| I | ARG268 |
| I | PHE281 |
| I | SFG501 |
| I | MG503 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG I 503 |
| Chain | Residue |
| I | ASN45 |
| I | HIS58 |
| I | GLU89 |
| I | GPP502 |
| site_id | DC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SFG J 501 |
| Chain | Residue |
| J | GLN30 |
| J | TRP37 |
| J | HIS57 |
| J | HIS58 |
| J | ASP111 |
| J | GLY113 |
| J | CYS114 |
| J | GLY115 |
| J | SER119 |
| J | THR135 |
| J | LEU136 |
| J | GLN140 |
| J | CYS162 |
| J | ASN163 |
| J | MET164 |
| J | ASN180 |
| J | GLU181 |
| J | SER182 |
| J | TYR185 |
| J | VAL186 |
| site_id | DC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GPP J 502 |
| Chain | Residue |
| J | TRP37 |
| J | ARG42 |
| J | ASN45 |
| J | HIS57 |
| J | HIS58 |
| J | TYR59 |
| J | GLU181 |
| J | MET184 |
| J | TYR185 |
| J | PHE230 |
| J | ARG268 |
| J | PHE281 |
| J | MG503 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG J 503 |
| Chain | Residue |
| J | ASN45 |
| J | HIS58 |
| J | GLU89 |
| J | GPP502 |
| site_id | DC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SFG K 501 |
| Chain | Residue |
| K | HIS57 |
| K | HIS58 |
| K | GLY113 |
| K | GLY115 |
| K | SER119 |
| K | THR135 |
| K | LEU136 |
| K | GLN140 |
| K | CYS162 |
| K | ASN163 |
| K | MET164 |
| K | ASN180 |
| K | GLU181 |
| K | SER182 |
| K | TYR185 |
| K | VAL186 |
| K | GPP502 |
| site_id | DC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GPP K 502 |
| Chain | Residue |
| K | ASN45 |
| K | HIS57 |
| K | HIS58 |
| K | TYR59 |
| K | GLU181 |
| K | MET184 |
| K | PHE230 |
| K | ARG268 |
| K | THR275 |
| K | SFG501 |
| K | MG503 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG K 503 |
| Chain | Residue |
| K | ASN45 |
| K | HIS58 |
| K | GLU89 |
| K | GPP502 |
| site_id | DC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SFG L 501 |
| Chain | Residue |
| L | GLN30 |
| L | TRP37 |
| L | HIS57 |
| L | HIS58 |
| L | GLY113 |
| L | GLY115 |
| L | THR135 |
| L | LEU136 |
| L | GLN140 |
| L | CYS162 |
| L | ASN163 |
| L | MET164 |
| L | ASN180 |
| L | GLU181 |
| L | SER182 |
| L | TYR185 |
| L | VAL186 |
| site_id | DC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GPP L 502 |
| Chain | Residue |
| L | TRP37 |
| L | ARG42 |
| L | ASN45 |
| L | HIS57 |
| L | TYR59 |
| L | GLU181 |
| L | MET184 |
| L | PHE230 |
| L | ARG268 |
| L | MG503 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG L 503 |
| Chain | Residue |
| L | ASN45 |
| L | HIS58 |
| L | GLU89 |
| L | GPP502 |
