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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4F52

Structure of a Glomulin-RBX1-CUL1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0006511biological_processubiquitin-dependent protein catabolic process
A0031625molecular_functionubiquitin protein ligase binding
B0000082biological_processG1/S transition of mitotic cell cycle
B0000109cellular_componentnucleotide-excision repair complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000165biological_processMAPK cascade
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006355biological_processregulation of DNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006513biological_processprotein monoubiquitination
B0006879biological_processintracellular iron ion homeostasis
B0006974biological_processDNA damage response
B0007283biological_processspermatogenesis
B0007346biological_processregulation of mitotic cell cycle
B0008270molecular_functionzinc ion binding
B0008283biological_processcell population proliferation
B0010506biological_processregulation of autophagy
B0010564biological_processregulation of cell cycle process
B0010824biological_processregulation of centrosome duplication
B0014033biological_processneural crest cell differentiation
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0019788molecular_functionNEDD8 transferase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0030510biological_processregulation of BMP signaling pathway
B0030891cellular_componentVCB complex
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031297biological_processreplication fork processing
B0031461cellular_componentcullin-RING ubiquitin ligase complex
B0031462cellular_componentCul2-RING ubiquitin ligase complex
B0031463cellular_componentCul3-RING ubiquitin ligase complex
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0031466cellular_componentCul5-RING ubiquitin ligase complex
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031625molecular_functionubiquitin protein ligase binding
B0032006biological_processregulation of TOR signaling
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032480biological_processnegative regulation of type I interferon production
B0032814biological_processregulation of natural killer cell activation
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0034599biological_processcellular response to oxidative stress
B0034644biological_processcellular response to UV
B0040029biological_processepigenetic regulation of gene expression
B0042110biological_processT cell activation
B0042127biological_processregulation of cell population proliferation
B0042752biological_processregulation of circadian rhythm
B0042770biological_processsignal transduction in response to DNA damage
B0042981biological_processregulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043687biological_processpost-translational protein modification
B0044314biological_processprotein K27-linked ubiquitination
B0044877molecular_functionprotein-containing complex binding
B0045116biological_processprotein neddylation
B0045732biological_processpositive regulation of protein catabolic process
B0045995biological_processregulation of embryonic development
B0046627biological_processnegative regulation of insulin receptor signaling pathway
B0046872molecular_functionmetal ion binding
B0050727biological_processregulation of inflammatory response
B0051298biological_processcentrosome duplication
B0051726biological_processregulation of cell cycle
B0060090molecular_functionmolecular adaptor activity
B0060173biological_processlimb development
B0060271biological_processcilium assembly
B0060964biological_processregulation of miRNA-mediated gene silencing
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061630molecular_functionubiquitin protein ligase activity
B0061663molecular_functionNEDD8 ligase activity
B0062197biological_processcellular response to chemical stress
B0070936biological_processprotein K48-linked ubiquitination
B0071230biological_processcellular response to amino acid stimulus
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
B0080135biological_processregulation of cellular response to stress
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090734cellular_componentsite of DNA damage
B0097602molecular_functioncullin family protein binding
B0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B0160240biological_processRNA polymerase II transcription initiation surveillance
B0160276biological_processnegative regulation of beige fat cell differentiation
B1900076biological_processregulation of cellular response to insulin stimulus
B1901524biological_processregulation of mitophagy
B1901525biological_processnegative regulation of mitophagy
B1901987biological_processregulation of cell cycle phase transition
B1902412biological_processregulation of mitotic cytokinesis
B1902499biological_processpositive regulation of protein autoubiquitination
B1902883biological_processnegative regulation of response to oxidative stress
B1904178biological_processnegative regulation of adipose tissue development
B1904263biological_processpositive regulation of TORC1 signaling
B1904415biological_processregulation of xenophagy
B1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
B2000001biological_processregulation of DNA damage checkpoint
B2000036biological_processregulation of stem cell population maintenance
B2000104biological_processnegative regulation of DNA-templated DNA replication
C0006511biological_processubiquitin-dependent protein catabolic process
C0031625molecular_functionubiquitin protein ligase binding
D0000082biological_processG1/S transition of mitotic cell cycle
D0000109cellular_componentnucleotide-excision repair complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000165biological_processMAPK cascade
D0000209biological_processprotein polyubiquitination
D0004842molecular_functionubiquitin-protein transferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006283biological_processtranscription-coupled nucleotide-excision repair
D0006289biological_processnucleotide-excision repair
D0006355biological_processregulation of DNA-templated transcription
D0006511biological_processubiquitin-dependent protein catabolic process
D0006513biological_processprotein monoubiquitination
D0006879biological_processintracellular iron ion homeostasis
D0006974biological_processDNA damage response
D0007283biological_processspermatogenesis
D0007346biological_processregulation of mitotic cell cycle
D0008270molecular_functionzinc ion binding
D0008283biological_processcell population proliferation
D0010506biological_processregulation of autophagy
D0010564biological_processregulation of cell cycle process
D0010824biological_processregulation of centrosome duplication
D0014033biological_processneural crest cell differentiation
D0016567biological_processprotein ubiquitination
D0016740molecular_functiontransferase activity
D0019005cellular_componentSCF ubiquitin ligase complex
D0019788molecular_functionNEDD8 transferase activity
D0030174biological_processregulation of DNA-templated DNA replication initiation
D0030510biological_processregulation of BMP signaling pathway
D0030891cellular_componentVCB complex
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031297biological_processreplication fork processing
D0031461cellular_componentcullin-RING ubiquitin ligase complex
D0031462cellular_componentCul2-RING ubiquitin ligase complex
D0031463cellular_componentCul3-RING ubiquitin ligase complex
D0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
D0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
D0031466cellular_componentCul5-RING ubiquitin ligase complex
D0031467cellular_componentCul7-RING ubiquitin ligase complex
D0031625molecular_functionubiquitin protein ligase binding
D0032006biological_processregulation of TOR signaling
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032480biological_processnegative regulation of type I interferon production
D0032814biological_processregulation of natural killer cell activation
D0034450molecular_functionubiquitin-ubiquitin ligase activity
D0034599biological_processcellular response to oxidative stress
D0034644biological_processcellular response to UV
D0040029biological_processepigenetic regulation of gene expression
D0042110biological_processT cell activation
D0042127biological_processregulation of cell population proliferation
D0042752biological_processregulation of circadian rhythm
D0042770biological_processsignal transduction in response to DNA damage
D0042981biological_processregulation of apoptotic process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043687biological_processpost-translational protein modification
D0044314biological_processprotein K27-linked ubiquitination
D0044877molecular_functionprotein-containing complex binding
D0045116biological_processprotein neddylation
D0045732biological_processpositive regulation of protein catabolic process
D0045995biological_processregulation of embryonic development
D0046627biological_processnegative regulation of insulin receptor signaling pathway
D0046872molecular_functionmetal ion binding
D0050727biological_processregulation of inflammatory response
D0051298biological_processcentrosome duplication
D0051726biological_processregulation of cell cycle
D0060090molecular_functionmolecular adaptor activity
D0060173biological_processlimb development
D0060271biological_processcilium assembly
D0060964biological_processregulation of miRNA-mediated gene silencing
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0061630molecular_functionubiquitin protein ligase activity
D0061663molecular_functionNEDD8 ligase activity
D0062197biological_processcellular response to chemical stress
D0070936biological_processprotein K48-linked ubiquitination
D0071230biological_processcellular response to amino acid stimulus
D0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
D0080135biological_processregulation of cellular response to stress
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090734cellular_componentsite of DNA damage
D0097602molecular_functioncullin family protein binding
D0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D0160240biological_processRNA polymerase II transcription initiation surveillance
D0160276biological_processnegative regulation of beige fat cell differentiation
D1900076biological_processregulation of cellular response to insulin stimulus
D1901524biological_processregulation of mitophagy
D1901525biological_processnegative regulation of mitophagy
D1901987biological_processregulation of cell cycle phase transition
D1902412biological_processregulation of mitotic cytokinesis
D1902499biological_processpositive regulation of protein autoubiquitination
D1902883biological_processnegative regulation of response to oxidative stress
D1904178biological_processnegative regulation of adipose tissue development
D1904263biological_processpositive regulation of TORC1 signaling
D1904415biological_processregulation of xenophagy
D1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
D2000001biological_processregulation of DNA damage checkpoint
D2000036biological_processregulation of stem cell population maintenance
D2000104biological_processnegative regulation of DNA-templated DNA replication
E0001570biological_processvasculogenesis
E0001819biological_processpositive regulation of cytokine production
E0005102molecular_functionsignaling receptor binding
E0005171molecular_functionhepatocyte growth factor receptor binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0007166biological_processcell surface receptor signaling pathway
E0008285biological_processnegative regulation of cell population proliferation
E0031461cellular_componentcullin-RING ubiquitin ligase complex
E0031462cellular_componentCul2-RING ubiquitin ligase complex
E0031463cellular_componentCul3-RING ubiquitin ligase complex
E0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
E0031625molecular_functionubiquitin protein ligase binding
E0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
E0032743biological_processpositive regulation of interleukin-2 production
E0040029biological_processepigenetic regulation of gene expression
E0042130biological_processnegative regulation of T cell proliferation
E0042327biological_processpositive regulation of phosphorylation
E0042692biological_processmuscle cell differentiation
E0055105molecular_functionubiquitin-protein transferase inhibitor activity
F0001570biological_processvasculogenesis
F0001819biological_processpositive regulation of cytokine production
F0005102molecular_functionsignaling receptor binding
F0005171molecular_functionhepatocyte growth factor receptor binding
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0007166biological_processcell surface receptor signaling pathway
F0008285biological_processnegative regulation of cell population proliferation
F0031461cellular_componentcullin-RING ubiquitin ligase complex
F0031462cellular_componentCul2-RING ubiquitin ligase complex
F0031463cellular_componentCul3-RING ubiquitin ligase complex
F0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
F0031625molecular_functionubiquitin protein ligase binding
F0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
F0032743biological_processpositive regulation of interleukin-2 production
F0040029biological_processepigenetic regulation of gene expression
F0042130biological_processnegative regulation of T cell proliferation
F0042327biological_processpositive regulation of phosphorylation
F0042692biological_processmuscle cell differentiation
F0055105molecular_functionubiquitin-protein transferase inhibitor activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 201
ChainResidue
BCYS42
BCYS45
BHIS80
BCYS83
site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 202
ChainResidue
BCYS75
BHIS77
BCYS94
BASP97
site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 203
ChainResidue
BCYS56
BCYS68
BHIS82
BCYS53
site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 201
ChainResidue
DCYS42
DCYS45
DHIS80
DCYS83
site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 202
ChainResidue
DCYS75
DHIS77
DCYS94
DASP97
site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 203
ChainResidue
DCYS53
DCYS56
DCYS68
DHIS82
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues45
DetailsZinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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