Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F52

Structure of a Glomulin-RBX1-CUL1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0031625	molecular_function	ubiquitin protein ligase binding
B	0000045	biological_process	autophagosome assembly
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000165	biological_process	MAPK cascade
B	0000209	biological_process	protein polyubiquitination
B	0000423	biological_process	mitophagy
B	0001837	biological_process	epithelial to mesenchymal transition
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006366	biological_process	transcription by RNA polymerase II
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006513	biological_process	protein monoubiquitination
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007040	biological_process	lysosome organization
B	0007283	biological_process	spermatogenesis
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008270	molecular_function	zinc ion binding
B	0008286	biological_process	insulin receptor signaling pathway
B	0010507	biological_process	negative regulation of autophagy
B	0010508	biological_process	positive regulation of autophagy
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0019221	biological_process	cytokine-mediated signaling pathway
B	0019788	molecular_function	NEDD8 transferase activity
B	0030163	biological_process	protein catabolic process
B	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
B	0030891	cellular_component	VCB complex
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0031461	cellular_component	cullin-RING ubiquitin ligase complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031669	biological_process	cellular response to nutrient levels
B	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032480	biological_process	negative regulation of type I interferon production
B	0032481	biological_process	positive regulation of type I interferon production
B	0032869	biological_process	cellular response to insulin stimulus
B	0034198	biological_process	cellular response to amino acid starvation
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0034644	biological_process	cellular response to UV
B	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
B	0038066	biological_process	p38MAPK cascade
B	0038202	biological_process	TORC1 signaling
B	0042110	biological_process	T cell activation
B	0042770	biological_process	signal transduction in response to DNA damage
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043687	biological_process	post-translational protein modification
B	0044877	molecular_function	protein-containing complex binding
B	0045116	biological_process	protein neddylation
B	0045727	biological_process	positive regulation of translation
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0046872	molecular_function	metal ion binding
B	0060090	molecular_function	molecular adaptor activity
B	0060337	biological_process	type I interferon-mediated signaling pathway
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061663	molecular_function	NEDD8 ligase activity
B	0062197	biological_process	cellular response to chemical stress
B	0070294	biological_process	renal sodium ion absorption
B	0070936	biological_process	protein K48-linked ubiquitination
B	0071230	biological_process	cellular response to amino acid stimulus
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0090734	cellular_component	site of DNA damage
B	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
B	0097602	molecular_function	cullin family protein binding
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	1900076	biological_process	regulation of cellular response to insulin stimulus
B	1901525	biological_process	negative regulation of mitophagy
B	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
B	1902499	biological_process	positive regulation of protein autoubiquitination
B	1902883	biological_process	negative regulation of response to oxidative stress
B	1904037	biological_process	positive regulation of epithelial cell apoptotic process
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
B	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0031625	molecular_function	ubiquitin protein ligase binding
D	0000045	biological_process	autophagosome assembly
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0000423	biological_process	mitophagy
D	0001837	biological_process	epithelial to mesenchymal transition
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007040	biological_process	lysosome organization
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008286	biological_process	insulin receptor signaling pathway
D	0010507	biological_process	negative regulation of autophagy
D	0010508	biological_process	positive regulation of autophagy
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032481	biological_process	positive regulation of type I interferon production
D	0032869	biological_process	cellular response to insulin stimulus
D	0034198	biological_process	cellular response to amino acid starvation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
D	0038066	biological_process	p38MAPK cascade
D	0038202	biological_process	TORC1 signaling
D	0042110	biological_process	T cell activation
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045727	biological_process	positive regulation of translation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070294	biological_process	renal sodium ion absorption
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901525	biological_process	negative regulation of mitophagy
D	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904037	biological_process	positive regulation of epithelial cell apoptotic process
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
E	0001570	biological_process	vasculogenesis
E	0001819	biological_process	positive regulation of cytokine production
E	0001843	biological_process	neural tube closure
E	0005102	molecular_function	signaling receptor binding
E	0005171	molecular_function	hepatocyte growth factor receptor binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0007166	biological_process	cell surface receptor signaling pathway
E	0008285	biological_process	negative regulation of cell population proliferation
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032743	biological_process	positive regulation of interleukin-2 production
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042130	biological_process	negative regulation of T cell proliferation
E	0042327	biological_process	positive regulation of phosphorylation
E	0042692	biological_process	muscle cell differentiation
E	0055105	molecular_function	ubiquitin-protein transferase inhibitor activity
E	0072359	biological_process	circulatory system development
F	0001570	biological_process	vasculogenesis
F	0001819	biological_process	positive regulation of cytokine production
F	0001843	biological_process	neural tube closure
F	0005102	molecular_function	signaling receptor binding
F	0005171	molecular_function	hepatocyte growth factor receptor binding
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0007166	biological_process	cell surface receptor signaling pathway
F	0008285	biological_process	negative regulation of cell population proliferation
F	0031461	cellular_component	cullin-RING ubiquitin ligase complex
F	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0040029	biological_process	epigenetic regulation of gene expression
F	0042130	biological_process	negative regulation of T cell proliferation
F	0042327	biological_process	positive regulation of phosphorylation
F	0042692	biological_process	muscle cell differentiation
F	0055105	molecular_function	ubiquitin-protein transferase inhibitor activity
F	0072359	biological_process	circulatory system development

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 201

Chain	Residue
B	CYS42
B	CYS45
B	HIS80
B	CYS83

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 202

Chain	Residue
B	CYS75
B	HIS77
B	CYS94
B	ASP97

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 203

Chain	Residue
B	CYS56
B	CYS68
B	HIS82
B	CYS53

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 201

Chain	Residue
D	CYS42
D	CYS45
D	HIS80
D	CYS83

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 202

Chain	Residue
D	CYS75
D	HIS77
D	CYS94
D	ASP97

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 203

Chain	Residue
D	CYS53
D	CYS56
D	CYS68
D	HIS82

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
E	ALA2
F	ALA2

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0000269\|PubMed:38605244, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DPL, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O, ECO:0007744\|PDB:8Q7H, ECO:0007744\|PDB:8RHZ

Chain	Residue	Details
B	CYS42
D	CYS75
D	HIS77
D	HIS80
D	CYS94
D	ASP97
B	CYS45
B	CYS75
B	HIS77
B	HIS80
B	CYS94
B	ASP97
D	CYS42
D	CYS45

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0000269\|PubMed:38605244, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DPL, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O, ECO:0007744\|PDB:7Z8B, ECO:0007744\|PDB:8Q7H, ECO:0007744\|PDB:8RHZ

Chain	Residue	Details
B	CYS53
B	CYS56
B	CYS68
B	HIS82
D	CYS53
D	CYS56
D	CYS68
D	HIS82

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:11961546, ECO:0000269\|PubMed:38605244, ECO:0007744\|PDB:1LDJ, ECO:0007744\|PDB:1LDK, ECO:0007744\|PDB:1U6G, ECO:0007744\|PDB:2HYE, ECO:0007744\|PDB:3DQV, ECO:0007744\|PDB:3RTR, ECO:0007744\|PDB:4F52, ECO:0007744\|PDB:4P5O, ECO:0007744\|PDB:8Q7H, ECO:0007744\|PDB:8RHZ

Chain	Residue	Details
B	CYS83
D	CYS83

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
B	THR9
D	THR9

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)