4F4O
Structure of the Haptoglobin-Haemoglobin Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005344 | molecular_function | oxygen carrier activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005833 | cellular_component | hemoglobin complex |
| A | 0015671 | biological_process | oxygen transport |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048821 | biological_process | erythrocyte development |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005833 | cellular_component | hemoglobin complex |
| B | 0015671 | biological_process | oxygen transport |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0031721 | molecular_function | hemoglobin alpha binding |
| B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048821 | biological_process | erythrocyte development |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0030492 | molecular_function | hemoglobin binding |
| D | 0005344 | molecular_function | oxygen carrier activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005833 | cellular_component | hemoglobin complex |
| D | 0015671 | biological_process | oxygen transport |
| D | 0019825 | molecular_function | oxygen binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048821 | biological_process | erythrocyte development |
| E | 0005344 | molecular_function | oxygen carrier activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005833 | cellular_component | hemoglobin complex |
| E | 0015671 | biological_process | oxygen transport |
| E | 0019825 | molecular_function | oxygen binding |
| E | 0020037 | molecular_function | heme binding |
| E | 0031721 | molecular_function | hemoglobin alpha binding |
| E | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0048821 | biological_process | erythrocyte development |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0006508 | biological_process | proteolysis |
| F | 0030492 | molecular_function | hemoglobin binding |
| G | 0005344 | molecular_function | oxygen carrier activity |
| G | 0005506 | molecular_function | iron ion binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005833 | cellular_component | hemoglobin complex |
| G | 0015671 | biological_process | oxygen transport |
| G | 0019825 | molecular_function | oxygen binding |
| G | 0020037 | molecular_function | heme binding |
| G | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0048821 | biological_process | erythrocyte development |
| H | 0005344 | molecular_function | oxygen carrier activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005833 | cellular_component | hemoglobin complex |
| H | 0015671 | biological_process | oxygen transport |
| H | 0019825 | molecular_function | oxygen binding |
| H | 0020037 | molecular_function | heme binding |
| H | 0031721 | molecular_function | hemoglobin alpha binding |
| H | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0048821 | biological_process | erythrocyte development |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005576 | cellular_component | extracellular region |
| I | 0006508 | biological_process | proteolysis |
| I | 0030492 | molecular_function | hemoglobin binding |
| J | 0005344 | molecular_function | oxygen carrier activity |
| J | 0005506 | molecular_function | iron ion binding |
| J | 0005515 | molecular_function | protein binding |
| J | 0005833 | cellular_component | hemoglobin complex |
| J | 0015671 | biological_process | oxygen transport |
| J | 0019825 | molecular_function | oxygen binding |
| J | 0020037 | molecular_function | heme binding |
| J | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0048821 | biological_process | erythrocyte development |
| K | 0005344 | molecular_function | oxygen carrier activity |
| K | 0005515 | molecular_function | protein binding |
| K | 0005833 | cellular_component | hemoglobin complex |
| K | 0015671 | biological_process | oxygen transport |
| K | 0019825 | molecular_function | oxygen binding |
| K | 0020037 | molecular_function | heme binding |
| K | 0031721 | molecular_function | hemoglobin alpha binding |
| K | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0048821 | biological_process | erythrocyte development |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0030492 | molecular_function | hemoglobin binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 32 |
| Details | Peptide: {"description":"Hemopressin","featureId":"PRO_0000455926","evidences":[{"source":"UniProtKB","id":"P01946","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1136 |
| Details | Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7990139","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7990139","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P69905","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"distal binding residue","evidences":[{"source":"UniProtKB","id":"P80044","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10713517","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QPW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PGH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F4O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"UniProtKB","id":"P02086","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P68871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 968 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | Region: {"description":"Interaction with CD163","evidences":[{"source":"PubMed","id":"22922649","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 16 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22922649","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
