Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F1E

The Crystal Structure of a Human MitoNEET mutant with Asp 67 replaced by a Gly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0010506	biological_process	regulation of autophagy
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0010506	biological_process	regulation of autophagy
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	0010506	biological_process	regulation of autophagy
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0010506	biological_process	regulation of autophagy
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0010506	biological_process	regulation of autophagy
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0010506	biological_process	regulation of autophagy
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0010506	biological_process	regulation of autophagy
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0010506	biological_process	regulation of autophagy
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0051537	molecular_function	2 iron, 2 sulfur cluster binding
I	0010506	biological_process	regulation of autophagy
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0051537	molecular_function	2 iron, 2 sulfur cluster binding
J	0010506	biological_process	regulation of autophagy
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0051537	molecular_function	2 iron, 2 sulfur cluster binding
K	0010506	biological_process	regulation of autophagy
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0051537	molecular_function	2 iron, 2 sulfur cluster binding
L	0010506	biological_process	regulation of autophagy
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0010506	biological_process	regulation of autophagy
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
N	0010506	biological_process	regulation of autophagy
N	0043231	cellular_component	intracellular membrane-bounded organelle
N	0051537	molecular_function	2 iron, 2 sulfur cluster binding
O	0010506	biological_process	regulation of autophagy
O	0043231	cellular_component	intracellular membrane-bounded organelle
O	0051537	molecular_function	2 iron, 2 sulfur cluster binding
P	0010506	biological_process	regulation of autophagy
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0010506	biological_process	regulation of autophagy
Q	0043231	cellular_component	intracellular membrane-bounded organelle
Q	0051537	molecular_function	2 iron, 2 sulfur cluster binding
R	0010506	biological_process	regulation of autophagy
R	0043231	cellular_component	intracellular membrane-bounded organelle
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 201

Chain	Residue
A	CYS72
A	ARG73
A	CYS74
A	CYS83
A	ASP84
A	ALA86
A	HIS87
A	PRO100

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES B 201

Chain	Residue
B	ARG73
B	CYS74
B	CYS83
B	ASP84
B	ALA86
B	HIS87
B	CYS72

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES C 201

Chain	Residue
C	CYS72
C	ARG73
C	CYS74
C	SER77
C	CYS83
C	ASP84
C	ALA86
C	HIS87

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES D 500

Chain	Residue
D	CYS72
D	ARG73
D	CYS74
D	SER77
D	CYS83
D	ASP84
D	ALA86
D	HIS87

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES E 201

Chain	Residue
E	CYS72
E	ARG73
E	CYS74
E	CYS83
E	ASP84
E	GLY85
E	ALA86
E	HIS87

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES F 201

Chain	Residue
F	CYS72
F	ARG73
F	CYS74
F	CYS83
F	ASP84
F	ALA86
F	HIS87

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES G 201

Chain	Residue
G	CYS72
G	ARG73
G	CYS74
G	CYS83
G	ASP84
G	GLY85
G	ALA86
G	HIS87

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES H 201

Chain	Residue
H	CYS72
H	ARG73
H	CYS74
H	SER77
H	CYS83
H	ASP84
H	ALA86
H	HIS87

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES I 201

Chain	Residue
I	CYS72
I	ARG73
I	CYS74
I	CYS83
I	ASP84
I	GLY85
I	ALA86
I	HIS87

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES J 201

Chain	Residue
J	CYS72
J	ARG73
J	CYS74
J	CYS83
J	ASP84
J	GLY85
J	ALA86
J	HIS87

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES K 201

Chain	Residue
K	CYS72
K	ARG73
K	CYS74
K	CYS83
K	ASP84
K	GLY85
K	ALA86
K	HIS87

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES L 201

Chain	Residue
L	CYS72
L	ARG73
L	CYS74
L	CYS83
L	ASP84
L	GLY85
L	ALA86
L	HIS87

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FES M 201

Chain	Residue
M	ASP84
M	GLY85
M	ALA86
M	HIS87
M	CYS72
M	ARG73
M	CYS74
M	SER77
M	CYS83

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES N 201

Chain	Residue
N	CYS72
N	ARG73
N	CYS74
N	CYS83
N	ASP84
N	ALA86
N	HIS87

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES O 201

Chain	Residue
O	CYS72
O	ARG73
O	CYS74
O	CYS83
O	ASP84
O	ALA86
O	HIS87

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES P 201

Chain	Residue
P	CYS72
P	ARG73
P	CYS74
P	SER77
P	CYS83
P	ASP84
P	ALA86
P	HIS87

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES Q 201

Chain	Residue
Q	CYS72
Q	ARG73
Q	CYS74
Q	CYS83
Q	ASP84
Q	ALA86
Q	HIS87

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES R 201

Chain	Residue
R	CYS72
R	ARG73
R	CYS74
R	SER77
R	CYS83
R	ASP84
R	ALA86
R	HIS87

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Active site: {"description":"Schiff-base intermediate with pyridoxal 5'-phosphate","evidences":[{"source":"PubMed","id":"36194135","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17766439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17766440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17905743","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QD0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R13","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	54
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91WS0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	118
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25621951","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	54
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"25621951","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)