Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F0X

Crystal structure of human Malonyl-CoA Decarboxylase (Peroxisomal Isoform)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002931	biological_process	response to ischemia
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0007584	biological_process	response to nutrient
A	0010906	biological_process	regulation of glucose metabolic process
A	0016831	molecular_function	carboxy-lyase activity
A	0019395	biological_process	fatty acid oxidation
A	0031998	biological_process	regulation of fatty acid beta-oxidation
A	0042802	molecular_function	identical protein binding
A	0046320	biological_process	regulation of fatty acid oxidation
A	0046321	biological_process	positive regulation of fatty acid oxidation
A	0050080	molecular_function	malonyl-CoA decarboxylase activity
A	2001294	biological_process	malonyl-CoA catabolic process
B	0002931	biological_process	response to ischemia
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0007584	biological_process	response to nutrient
B	0010906	biological_process	regulation of glucose metabolic process
B	0016831	molecular_function	carboxy-lyase activity
B	0019395	biological_process	fatty acid oxidation
B	0031998	biological_process	regulation of fatty acid beta-oxidation
B	0042802	molecular_function	identical protein binding
B	0046320	biological_process	regulation of fatty acid oxidation
B	0046321	biological_process	positive regulation of fatty acid oxidation
B	0050080	molecular_function	malonyl-CoA decarboxylase activity
B	2001294	biological_process	malonyl-CoA catabolic process
C	0002931	biological_process	response to ischemia
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006085	biological_process	acetyl-CoA biosynthetic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0007584	biological_process	response to nutrient
C	0010906	biological_process	regulation of glucose metabolic process
C	0016831	molecular_function	carboxy-lyase activity
C	0019395	biological_process	fatty acid oxidation
C	0031998	biological_process	regulation of fatty acid beta-oxidation
C	0042802	molecular_function	identical protein binding
C	0046320	biological_process	regulation of fatty acid oxidation
C	0046321	biological_process	positive regulation of fatty acid oxidation
C	0050080	molecular_function	malonyl-CoA decarboxylase activity
C	2001294	biological_process	malonyl-CoA catabolic process
D	0002931	biological_process	response to ischemia
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006085	biological_process	acetyl-CoA biosynthetic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0007584	biological_process	response to nutrient
D	0010906	biological_process	regulation of glucose metabolic process
D	0016831	molecular_function	carboxy-lyase activity
D	0019395	biological_process	fatty acid oxidation
D	0031998	biological_process	regulation of fatty acid beta-oxidation
D	0042802	molecular_function	identical protein binding
D	0046320	biological_process	regulation of fatty acid oxidation
D	0046321	biological_process	positive regulation of fatty acid oxidation
D	0050080	molecular_function	malonyl-CoA decarboxylase activity
D	2001294	biological_process	malonyl-CoA catabolic process
E	0002931	biological_process	response to ischemia
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006085	biological_process	acetyl-CoA biosynthetic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0006637	biological_process	acyl-CoA metabolic process
E	0007584	biological_process	response to nutrient
E	0010906	biological_process	regulation of glucose metabolic process
E	0016831	molecular_function	carboxy-lyase activity
E	0019395	biological_process	fatty acid oxidation
E	0031998	biological_process	regulation of fatty acid beta-oxidation
E	0042802	molecular_function	identical protein binding
E	0046320	biological_process	regulation of fatty acid oxidation
E	0046321	biological_process	positive regulation of fatty acid oxidation
E	0050080	molecular_function	malonyl-CoA decarboxylase activity
E	2001294	biological_process	malonyl-CoA catabolic process
F	0002931	biological_process	response to ischemia
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006085	biological_process	acetyl-CoA biosynthetic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0006637	biological_process	acyl-CoA metabolic process
F	0007584	biological_process	response to nutrient
F	0010906	biological_process	regulation of glucose metabolic process
F	0016831	molecular_function	carboxy-lyase activity
F	0019395	biological_process	fatty acid oxidation
F	0031998	biological_process	regulation of fatty acid beta-oxidation
F	0042802	molecular_function	identical protein binding
F	0046320	biological_process	regulation of fatty acid oxidation
F	0046321	biological_process	positive regulation of fatty acid oxidation
F	0050080	molecular_function	malonyl-CoA decarboxylase activity
F	2001294	biological_process	malonyl-CoA catabolic process
G	0002931	biological_process	response to ischemia
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005777	cellular_component	peroxisome
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0006085	biological_process	acetyl-CoA biosynthetic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0006637	biological_process	acyl-CoA metabolic process
G	0007584	biological_process	response to nutrient
G	0010906	biological_process	regulation of glucose metabolic process
G	0016831	molecular_function	carboxy-lyase activity
G	0019395	biological_process	fatty acid oxidation
G	0031998	biological_process	regulation of fatty acid beta-oxidation
G	0042802	molecular_function	identical protein binding
G	0046320	biological_process	regulation of fatty acid oxidation
G	0046321	biological_process	positive regulation of fatty acid oxidation
G	0050080	molecular_function	malonyl-CoA decarboxylase activity
G	2001294	biological_process	malonyl-CoA catabolic process
H	0002931	biological_process	response to ischemia
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005777	cellular_component	peroxisome
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0006085	biological_process	acetyl-CoA biosynthetic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0006637	biological_process	acyl-CoA metabolic process
H	0007584	biological_process	response to nutrient
H	0010906	biological_process	regulation of glucose metabolic process
H	0016831	molecular_function	carboxy-lyase activity
H	0019395	biological_process	fatty acid oxidation
H	0031998	biological_process	regulation of fatty acid beta-oxidation
H	0042802	molecular_function	identical protein binding
H	0046320	biological_process	regulation of fatty acid oxidation
H	0046321	biological_process	positive regulation of fatty acid oxidation
H	0050080	molecular_function	malonyl-CoA decarboxylase activity
H	2001294	biological_process	malonyl-CoA catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0OR B 501

Chain	Residue
B	ILE291
B	PHE422
B	HIS423
B	LEU293
B	GLY300
B	VAL301
B	GLU302
B	LEU303
B	GLY304
B	SER329
B	PRO330

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0OR D 501

Chain	Residue
D	ILE291
D	LEU293
D	GLY300
D	VAL301
D	GLU302
D	LEU303
D	GLY304
D	THR305
D	SER329
D	PRO330
D	PHE422
D	HIS423

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0OR E 501

Chain	Residue
E	ILE291
E	LEU293
E	GLY300
E	VAL301
E	GLU302
E	LEU303
E	GLY304
E	SER329
E	PRO330
E	PHE422
E	HIS423

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0OR G 501

Chain	Residue
G	ILE291
G	LEU293
G	GLY300
G	VAL301
G	GLU302
G	LEU303
G	GLY304
G	THR305
G	SER329
G	PRO330
G	PHE422
G	HIS423

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:23791943

Chain	Residue	Details
A	SER329
B	SER329
C	SER329
D	SER329
E	SER329
F	SER329
G	SER329
H	SER329

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:23791943

Chain	Residue	Details
A	HIS423
B	HIS423
C	HIS423
D	HIS423
E	HIS423
F	HIS423
G	HIS423
H	HIS423

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLN299
D	GLN299
D	SER329
D	HIS423
E	GLN299
E	SER329
E	HIS423
F	GLN299
F	SER329
F	HIS423
G	GLN299
A	SER329
G	SER329
G	HIS423
H	GLN299
H	SER329
H	HIS423
A	HIS423
B	GLN299
B	SER329
B	HIS423
C	GLN299
C	SER329
C	HIS423

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Essential for catalytic activity => ECO:0000250

Chain	Residue	Details
A	LYS211
B	LYS211
C	LYS211
D	LYS211
E	LYS211
F	LYS211
G	LYS211
H	LYS211

site_id	SWS_FT_FI5
Number of Residues	32
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q99J39

Chain	Residue	Details
A	LYS59
C	LYS211
C	LYS389
C	LYS472
D	LYS59
D	LYS211
D	LYS389
D	LYS472
E	LYS59
E	LYS211
E	LYS389
A	LYS211
E	LYS472
F	LYS59
F	LYS211
F	LYS389
F	LYS472
G	LYS59
G	LYS211
G	LYS389
G	LYS472
H	LYS59
A	LYS389
H	LYS211
H	LYS389
H	LYS472
A	LYS472
B	LYS59
B	LYS211
B	LYS389
B	LYS472
C	LYS59

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q99J39

Chain	Residue	Details
A	LYS168
B	LYS168
C	LYS168
D	LYS168
E	LYS168
F	LYS168
G	LYS168
H	LYS168

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q99J39

Chain	Residue	Details
A	LYS222
B	LYS222
C	LYS222
D	LYS222
E	LYS222
F	LYS222
G	LYS222
H	LYS222

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)