Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F0X

Crystal structure of human Malonyl-CoA Decarboxylase (Peroxisomal Isoform)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002931	biological_process	response to ischemia
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0005829	cellular_component	cytosol
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0007584	biological_process	response to nutrient
A	0010906	biological_process	regulation of glucose metabolic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019395	biological_process	fatty acid oxidation
A	0031998	biological_process	regulation of fatty acid beta-oxidation
A	0042802	molecular_function	identical protein binding
A	0046320	biological_process	regulation of fatty acid oxidation
A	0046321	biological_process	positive regulation of fatty acid oxidation
A	0050080	molecular_function	malonyl-CoA decarboxylase activity
A	2001294	biological_process	malonyl-CoA catabolic process
B	0002931	biological_process	response to ischemia
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0005829	cellular_component	cytosol
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0007584	biological_process	response to nutrient
B	0010906	biological_process	regulation of glucose metabolic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019395	biological_process	fatty acid oxidation
B	0031998	biological_process	regulation of fatty acid beta-oxidation
B	0042802	molecular_function	identical protein binding
B	0046320	biological_process	regulation of fatty acid oxidation
B	0046321	biological_process	positive regulation of fatty acid oxidation
B	0050080	molecular_function	malonyl-CoA decarboxylase activity
B	2001294	biological_process	malonyl-CoA catabolic process
C	0002931	biological_process	response to ischemia
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0005829	cellular_component	cytosol
C	0006085	biological_process	acetyl-CoA biosynthetic process
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0007584	biological_process	response to nutrient
C	0010906	biological_process	regulation of glucose metabolic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019395	biological_process	fatty acid oxidation
C	0031998	biological_process	regulation of fatty acid beta-oxidation
C	0042802	molecular_function	identical protein binding
C	0046320	biological_process	regulation of fatty acid oxidation
C	0046321	biological_process	positive regulation of fatty acid oxidation
C	0050080	molecular_function	malonyl-CoA decarboxylase activity
C	2001294	biological_process	malonyl-CoA catabolic process
D	0002931	biological_process	response to ischemia
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0005829	cellular_component	cytosol
D	0006085	biological_process	acetyl-CoA biosynthetic process
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0007584	biological_process	response to nutrient
D	0010906	biological_process	regulation of glucose metabolic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0019395	biological_process	fatty acid oxidation
D	0031998	biological_process	regulation of fatty acid beta-oxidation
D	0042802	molecular_function	identical protein binding
D	0046320	biological_process	regulation of fatty acid oxidation
D	0046321	biological_process	positive regulation of fatty acid oxidation
D	0050080	molecular_function	malonyl-CoA decarboxylase activity
D	2001294	biological_process	malonyl-CoA catabolic process
E	0002931	biological_process	response to ischemia
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005777	cellular_component	peroxisome
E	0005782	cellular_component	peroxisomal matrix
E	0005829	cellular_component	cytosol
E	0006085	biological_process	acetyl-CoA biosynthetic process
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0006637	biological_process	acyl-CoA metabolic process
E	0007584	biological_process	response to nutrient
E	0010906	biological_process	regulation of glucose metabolic process
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019395	biological_process	fatty acid oxidation
E	0031998	biological_process	regulation of fatty acid beta-oxidation
E	0042802	molecular_function	identical protein binding
E	0046320	biological_process	regulation of fatty acid oxidation
E	0046321	biological_process	positive regulation of fatty acid oxidation
E	0050080	molecular_function	malonyl-CoA decarboxylase activity
E	2001294	biological_process	malonyl-CoA catabolic process
F	0002931	biological_process	response to ischemia
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005777	cellular_component	peroxisome
F	0005782	cellular_component	peroxisomal matrix
F	0005829	cellular_component	cytosol
F	0006085	biological_process	acetyl-CoA biosynthetic process
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0006637	biological_process	acyl-CoA metabolic process
F	0007584	biological_process	response to nutrient
F	0010906	biological_process	regulation of glucose metabolic process
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019395	biological_process	fatty acid oxidation
F	0031998	biological_process	regulation of fatty acid beta-oxidation
F	0042802	molecular_function	identical protein binding
F	0046320	biological_process	regulation of fatty acid oxidation
F	0046321	biological_process	positive regulation of fatty acid oxidation
F	0050080	molecular_function	malonyl-CoA decarboxylase activity
F	2001294	biological_process	malonyl-CoA catabolic process
G	0002931	biological_process	response to ischemia
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005777	cellular_component	peroxisome
G	0005782	cellular_component	peroxisomal matrix
G	0005829	cellular_component	cytosol
G	0006085	biological_process	acetyl-CoA biosynthetic process
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0006637	biological_process	acyl-CoA metabolic process
G	0007584	biological_process	response to nutrient
G	0010906	biological_process	regulation of glucose metabolic process
G	0016829	molecular_function	lyase activity
G	0016831	molecular_function	carboxy-lyase activity
G	0019395	biological_process	fatty acid oxidation
G	0031998	biological_process	regulation of fatty acid beta-oxidation
G	0042802	molecular_function	identical protein binding
G	0046320	biological_process	regulation of fatty acid oxidation
G	0046321	biological_process	positive regulation of fatty acid oxidation
G	0050080	molecular_function	malonyl-CoA decarboxylase activity
G	2001294	biological_process	malonyl-CoA catabolic process
H	0002931	biological_process	response to ischemia
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005777	cellular_component	peroxisome
H	0005782	cellular_component	peroxisomal matrix
H	0005829	cellular_component	cytosol
H	0006085	biological_process	acetyl-CoA biosynthetic process
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0006637	biological_process	acyl-CoA metabolic process
H	0007584	biological_process	response to nutrient
H	0010906	biological_process	regulation of glucose metabolic process
H	0016829	molecular_function	lyase activity
H	0016831	molecular_function	carboxy-lyase activity
H	0019395	biological_process	fatty acid oxidation
H	0031998	biological_process	regulation of fatty acid beta-oxidation
H	0042802	molecular_function	identical protein binding
H	0046320	biological_process	regulation of fatty acid oxidation
H	0046321	biological_process	positive regulation of fatty acid oxidation
H	0050080	molecular_function	malonyl-CoA decarboxylase activity
H	2001294	biological_process	malonyl-CoA catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0OR B 501

Chain	Residue
B	ILE291
B	PHE422
B	HIS423
B	LEU293
B	GLY300
B	VAL301
B	GLU302
B	LEU303
B	GLY304
B	SER329
B	PRO330

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0OR D 501

Chain	Residue
D	ILE291
D	LEU293
D	GLY300
D	VAL301
D	GLU302
D	LEU303
D	GLY304
D	THR305
D	SER329
D	PRO330
D	PHE422
D	HIS423

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0OR E 501

Chain	Residue
E	ILE291
E	LEU293
E	GLY300
E	VAL301
E	GLU302
E	LEU303
E	GLY304
E	SER329
E	PRO330
E	PHE422
E	HIS423

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0OR G 501

Chain	Residue
G	ILE291
G	LEU293
G	GLY300
G	VAL301
G	GLU302
G	LEU303
G	GLY304
G	THR305
G	SER329
G	PRO330
G	PHE422
G	HIS423

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	600
Details	Region: {"description":"Alpha-helical domain"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	302
Details	Region: {"description":"Catalytic domain"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Motif: {"description":"Microbody targeting signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23791943","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"23791943","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	64
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	28
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99J39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99J39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99J39","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)