4EYH
Human DNA polymerase iota incorporating dCTP opposite N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DCP B 501 |
| Chain | Residue |
| B | LEU35 |
| B | ASP126 |
| B | LYS214 |
| B | MG502 |
| B | MG504 |
| P | DC873 |
| T | DG8840 |
| T | DG841 |
| B | CYS37 |
| B | PHE38 |
| B | TYR39 |
| B | VAL64 |
| B | THR65 |
| B | TYR68 |
| B | ARG71 |
| B | LYS77 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 502 |
| Chain | Residue |
| B | ASP34 |
| B | LEU35 |
| B | DCP501 |
| B | HOH601 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | LYS237 |
| B | ILE239 |
| B | ILE242 |
| B | HOH624 |
| P | DC872 |
| P | HOH901 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 504 |
| Chain | Residue |
| B | ASP34 |
| B | GLU127 |
| B | DCP501 |
| P | DC873 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 213 |
| Details | Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 65 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
