4EWE
Study on structure and function relationships in human Pirin with Manganese ion
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003712 | molecular_function | transcription coregulator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0007586 | biological_process | digestion |
| A | 0008127 | molecular_function | quercetin 2,3-dioxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016604 | cellular_component | nuclear body |
| A | 0030099 | biological_process | myeloid cell differentiation |
| A | 0030224 | biological_process | monocyte differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1001 |
| Chain | Residue |
| A | HIS56 |
| A | HIS58 |
| A | HIS101 |
| A | GLU103 |
| A | HOH1110 |
| A | HOH1160 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1002 |
| Chain | Residue |
| A | LYS46 |
| A | HOH1270 |
| A | ARG23 |
| A | ARG25 |
| A | GLU44 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | LYS141 |
| A | THR148 |
| A | ALA150 |
| A | ASP173 |
| A | LYS175 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | LYS144 |
| A | ASP145 |
| A | HIS182 |
| A | HOH1154 |
| A | HOH1302 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | ASP43 |
| A | HOH1174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14573596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20711196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ACL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
