Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4EV6

The complete structure of CorA magnesium transporter from Methanocaldococcus jannaschii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UMQ A 401

Chain	Residue
A	ASP86
A	LEU184
A	PHE187
A	LEU191
A	THR88
A	TYR147
A	ILE150
A	LEU151
A	ASN153
A	LEU154
A	GLU157
A	LYS176

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ A 402

Chain	Residue
A	GLN291
A	TRP294
B	TYR283
E	GLU212
E	HOH558

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	LEU118

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 404

Chain	Residue
A	ASP70

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 405

Chain	Residue
A	ASP72
A	ASN98
A	MG408
A	MG409

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 406

Chain	Residue
A	GLU69

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 407

Chain	Residue
A	GLU162

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 408

Chain	Residue
A	MG405
A	HOH516

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 409

Chain	Residue
A	GLU71
A	ASP72
A	MG405
A	HOH527

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE UMQ B 401

Chain	Residue
B	GLN291
B	TRP294
C	TYR283
C	UMQ401

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ B 402

Chain	Residue
A	MET297
B	ILE276
B	TYR277
B	PRO285
B	LEU299

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 404

Chain	Residue
B	THR264

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UMQ C 401

Chain	Residue
A	TYR205
A	PRO207
B	PHE293
B	TRP294
B	UMQ401
C	ILE273
C	ILE276
C	TYR277
C	PRO285
C	ASN289
C	LEU299

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 404

Chain	Residue
C	GLU69

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ D 401

Chain	Residue
B	GLU212
C	GLN291
C	TRP294
D	TYR283
D	LEU286

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 402

Chain	Residue
D	GLU155

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 403

Chain	Residue
D	GLU157

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 404

Chain	Residue
D	VAL237

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 405

Chain	Residue
D	ASP219
D	ASP223

site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 406

Chain	Residue
D	LYS204

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 407

Chain	Residue
D	ASP54
D	ASP70
D	PHE73

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 409

Chain	Residue
D	ILE57
D	LEU75

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 410

Chain	Residue
D	GLY49
D	ILE50
D	HOH513

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 411

Chain	Residue
D	ILE126
D	VAL127

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ E 401

Chain	Residue
A	TYR283
E	GLN291
E	TRP294
E	HOH559
E	HOH560

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE UMQ E 402

Chain	Residue
E	LYS9
E	ASP10
E	ILE119
E	LEU135
E	HIS138

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 404

Chain	Residue
E	VAL67
E	HOH524

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 406

Chain	Residue
A	GLU155
E	TYR186
E	HOH562

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG E 407

Chain	Residue
E	ASP54
E	ILE57
E	GLU68
E	ASP70

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG E 410

Chain	Residue
E	LYS204

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 411

Chain	Residue
E	VAL67
E	LYS204

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1310
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-LYS258
E	ARG312-ILE317
A	ARG312-ILE317
B	MET1-LYS258
B	ARG312-ILE317
C	MET1-LYS258
C	ARG312-ILE317
D	MET1-LYS258
D	ARG312-ILE317
E	MET1-LYS258

site_id	SWS_FT_FI2
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:23091000

Chain	Residue	Details
A	ILE259-MET279
E	GLN291-PHE311
A	GLN291-PHE311
B	ILE259-MET279
B	GLN291-PHE311
C	ILE259-MET279
C	GLN291-PHE311
D	ILE259-MET279
D	GLN291-PHE311
E	ILE259-MET279

site_id	SWS_FT_FI3
Number of Residues	50
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN280-PRO290
B	ASN280-PRO290
C	ASN280-PRO290
D	ASN280-PRO290
E	ASN280-PRO290

site_id	SWS_FT_FI4
Number of Residues	5
Details	SITE: Essential for ion permeation => ECO:0000250\|UniProtKB:Q9WZ31

Chain	Residue	Details
A	ASN254
B	ASN254
C	ASN254
D	ASN254
E	ASN254

site_id	SWS_FT_FI5
Number of Residues	5
Details	SITE: Important for closing the ion permeation pathway in the closed state => ECO:0000269\|PubMed:23091000

Chain	Residue	Details
A	LEU260
B	LEU260
C	LEU260
D	LEU260
E	LEU260

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Threonine that confers selectivity for Co(2+) transport => ECO:0000250\|UniProtKB:Q9WZ31

Chain	Residue	Details
A	THR261
B	THR261
C	THR261
D	THR261
E	THR261

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)