4ETW
Structure of the Enzyme-ACP Substrate Gatekeeper Complex Required for Biotin Synthesis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009102 | biological_process | biotin biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0090499 | molecular_function | pimelyl-[acyl-carrier protein] methyl ester esterase activity |
| B | 0000035 | molecular_function | acyl binding |
| B | 0000036 | molecular_function | acyl carrier activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009102 | biological_process | biotin biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| C | 0090499 | molecular_function | pimelyl-[acyl-carrier protein] methyl ester esterase activity |
| D | 0000035 | molecular_function | acyl binding |
| D | 0000036 | molecular_function | acyl carrier activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZMK D 600 |
| Chain | Residue |
| C | GLY21 |
| C | LEU183 |
| C | HIS235 |
| D | SER535 |
| D | LEU536 |
| C | TRP22 |
| C | ALA82 |
| C | LEU83 |
| C | VAL124 |
| C | PHE128 |
| C | PHE143 |
| C | LEU146 |
| C | GLN147 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ZMK B 600 |
| Chain | Residue |
| A | GLY21 |
| A | TRP22 |
| A | ALA82 |
| A | LEU83 |
| A | VAL124 |
| A | LEU125 |
| A | PHE128 |
| A | PHE143 |
| A | GLN147 |
| A | LEU183 |
| A | HIS235 |
| B | SER535 |
| B | LEU536 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| D | ASP530-LEU545 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258 |
| Chain | Residue | Details |
| D | SER535 | |
| B | SER535 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01260 |
| Chain | Residue | Details |
| A | ASP207 | |
| A | HIS235 | |
| C | ASP207 | |
| C | HIS235 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01260 |
| Chain | Residue | Details |
| A | TRP22 | |
| A | ALA82 | |
| A | PHE143 | |
| A | HIS235 | |
| C | TRP22 | |
| C | ALA82 | |
| C | PHE143 | |
| C | HIS235 |
