4EP7

Functional implications from the Cid1 poly(U) polymerase crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016779	molecular_function	nucleotidyltransferase activity
B	0016779	molecular_function	nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE UTP A 501

Chain	Residue
A	PHE88
A	SER211
A	TYR212
A	HIS336
A	MG503
A	MG505
A	HOH606
A	HOH619
A	HOH624
A	HOH664
A	HOH666
A	GLY89
A	HOH670
A	HOH685
A	HOH713
A	HOH725
A	HOH726
A	SER90
A	ASP103
A	ALA168
A	ASN171
A	THR172
A	LYS193
A	LYS197

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	ARG277

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 503

Chain	Residue
A	ASP103
A	UTP501
A	HOH685
A	HOH713
A	HOH725

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 504

Chain	Residue
A	LYS199
A	HOH616

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 505

Chain	Residue
A	ASN165
A	UTP501
A	HOH701

---

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE UTP B 501

Chain	Residue
B	PHE88
B	GLY89
B	SER90
B	ASP101
B	ASP103
B	ALA168
B	ASN171
B	THR172
B	LYS193
B	LYS197
B	SER211
B	TYR212
B	HIS336
B	MG503
B	MG504
B	HOH611
B	HOH617
B	HOH638
B	HOH712
B	HOH713
B	HOH714
B	HOH715
B	HOH716

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	LEU74

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 503

Chain	Residue
B	ASP101
B	ASP103
B	UTP501
B	HOH715

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 504

Chain	Residue
B	ASN165
B	UTP501
B	HOH634

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---