Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4EO4

Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004829	molecular_function	threonine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006435	biological_process	threonyl-tRNA aminoacylation
A	0008270	molecular_function	zinc ion binding
A	0016874	molecular_function	ligase activity
A	0070159	biological_process	mitochondrial threonyl-tRNA aminoacylation
A	0140101	molecular_function	catalytic activity, acting on a tRNA
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004829	molecular_function	threonine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006435	biological_process	threonyl-tRNA aminoacylation
B	0008270	molecular_function	zinc ion binding
B	0016874	molecular_function	ligase activity
B	0070159	biological_process	mitochondrial threonyl-tRNA aminoacylation
B	0140101	molecular_function	catalytic activity, acting on a tRNA
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004829	molecular_function	threonine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006435	biological_process	threonyl-tRNA aminoacylation
C	0008270	molecular_function	zinc ion binding
C	0016874	molecular_function	ligase activity
C	0070159	biological_process	mitochondrial threonyl-tRNA aminoacylation
C	0140101	molecular_function	catalytic activity, acting on a tRNA
D	0000166	molecular_function	nucleotide binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004829	molecular_function	threonine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006435	biological_process	threonyl-tRNA aminoacylation
D	0008270	molecular_function	zinc ion binding
D	0016874	molecular_function	ligase activity
D	0070159	biological_process	mitochondrial threonyl-tRNA aminoacylation
D	0140101	molecular_function	catalytic activity, acting on a tRNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SSA A 1001

Chain	Residue
A	MET131
A	GLN287
A	VAL288
A	GLN292
A	HIS319
A	GLY324
A	SER325
A	ARG328
A	ZN1003
A	HOH1101
A	ARG162
A	GLU164
A	THR173
A	ARG174
A	LEU175
A	PHE178
A	GLN180
A	ASP182

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SSA A 1002

Chain	Residue
A	VAL403
A	GLY404
A	ILE407
A	LYS408
A	ILE411
A	ARG434
A	ARG439
A	HOH1217
A	HOH1218
A	HOH1219
A	HOH1220

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1003

Chain	Residue
A	CYS133
A	HIS184
A	HIS319
A	SSA1001

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SSA B 1001

Chain	Residue
B	MET131
B	CYS133
B	ARG162
B	GLU164
B	THR173
B	ARG174
B	LEU175
B	PHE178
B	GLN180
B	ASP182
B	GLN287
B	VAL288
B	GLN292
B	HIS319
B	GLY324
B	SER325
B	ARG328
B	ZN1003
B	HOH1107

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SSA B 1002

Chain	Residue
B	VAL403
B	GLY404
B	LYS408
B	ILE411
B	ARG434
B	ARG436
B	ARG439
B	HOH1192
B	HOH1193
B	HOH1194
B	HOH1195

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1003

Chain	Residue
B	CYS133
B	HIS184
B	HIS319
B	SSA1001

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SSA C 1001

Chain	Residue
C	MET131
C	ARG162
C	GLU164
C	THR173
C	ARG174
C	LEU175
C	PHE178
C	GLN180
C	ASP182
C	TYR270
C	LYS273
C	GLN287
C	VAL288
C	GLN292
C	HIS319
C	GLY324
C	SER325
C	ARG328
C	ZN1003
C	HOH1135
C	HOH1137

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SSA C 1002

Chain	Residue
B	LYS408
B	HOH1195
C	VAL403
C	LYS408
C	ILE411
C	ARG434
C	ARG439
C	HOH1157
C	HOH1165
C	HOH1166

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1003

Chain	Residue
C	HIS184
C	HIS319
C	SSA1001
C	CYS133

site_id	BC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SSA D 1001

Chain	Residue
D	MET131
D	CYS133
D	ARG162
D	GLU164
D	THR173
D	LEU175
D	PHE178
D	GLN180
D	ASP182
D	TYR270
D	LYS273
D	GLN287
D	VAL288
D	GLN292
D	GLY324
D	SER325
D	ARG328
D	ZN1003
D	HOH1129

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SSA D 1002

Chain	Residue
A	HOH1220
D	VAL403
D	LYS408
D	ARG434
D	ARG439
D	HOH1156
D	HOH1157

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1003

Chain	Residue
D	CYS133
D	HIS184
D	HIS319
D	SSA1001

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)