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4ENO

Crystal structure of oxidized human nm23-H1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003723molecular_functionRNA binding
A0004536molecular_functionDNA nuclease activity
A0004550molecular_functionnucleoside diphosphate kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005769cellular_componentearly endosome
A0005829cellular_componentcytosol
A0006183biological_processGTP biosynthetic process
A0006228biological_processUTP biosynthetic process
A0006241biological_processCTP biosynthetic process
A0006259biological_processDNA metabolic process
A0006897biological_processendocytosis
A0007399biological_processnervous system development
A0007595biological_processlactation
A0008285biological_processnegative regulation of cell population proliferation
A0008408molecular_function3'-5' exonuclease activity
A0009117biological_processnucleotide metabolic process
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0030154biological_processcell differentiation
A0030879biological_processmammary gland development
A0032587cellular_componentruffle membrane
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043024molecular_functionribosomal small subunit binding
A0043388biological_processpositive regulation of DNA binding
A0046872molecular_functionmetal ion binding
A0050679biological_processpositive regulation of epithelial cell proliferation
A0070062cellular_componentextracellular exosome
B0000287molecular_functionmagnesium ion binding
B0003723molecular_functionRNA binding
B0004536molecular_functionDNA nuclease activity
B0004550molecular_functionnucleoside diphosphate kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005769cellular_componentearly endosome
B0005829cellular_componentcytosol
B0006183biological_processGTP biosynthetic process
B0006228biological_processUTP biosynthetic process
B0006241biological_processCTP biosynthetic process
B0006259biological_processDNA metabolic process
B0006897biological_processendocytosis
B0007399biological_processnervous system development
B0007595biological_processlactation
B0008285biological_processnegative regulation of cell population proliferation
B0008408molecular_function3'-5' exonuclease activity
B0009117biological_processnucleotide metabolic process
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0030154biological_processcell differentiation
B0030879biological_processmammary gland development
B0032587cellular_componentruffle membrane
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043024molecular_functionribosomal small subunit binding
B0043388biological_processpositive regulation of DNA binding
B0046872molecular_functionmetal ion binding
B0050679biological_processpositive regulation of epithelial cell proliferation
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 A 201
ChainResidue
ALYS12
ATYR52
AHIS118

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 B 201
ChainResidue
BLYS12
BTYR52
BHIS118
BHOH304

Functional Information from PROSITE/UniProt
site_idPS00469
Number of Residues9
DetailsNDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSV
ChainResidueDetails
AASN115-VAL123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Pros-phosphohistidine intermediate => ECO:0000269|PubMed:1851158
ChainResidueDetails
AHIS118
BHIS118

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
ALYS12
BTHR94
BARG105
BASN115
APHE60
AARG88
ATHR94
AARG105
AASN115
BLYS12
BPHE60
BARG88

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER120
ASER122
ASER125
BSER120
BSER122
BSER125

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS100
BLYS100

221716

PDB entries from 2024-06-26

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