4ENK
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-propylguanine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006281 | biological_process | DNA repair |
| A | 0006283 | biological_process | transcription-coupled nucleotide-excision repair |
| A | 0032132 | molecular_function | O6-alkylguanine-DNA binding |
| A | 0070911 | biological_process | global genome nucleotide-excision repair |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Required for phosphate rotation/nucleotide flipping => ECO:0000305|PubMed:19516334 |
| Chain | Residue | Details |
| A | TYR25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Arg finger, required for nucleotide flipping => ECO:0000305|PubMed:19516334 |
| Chain | Residue | Details |
| A | ARG39 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Critical for recognition of O(6)-alkylguanines, probes the electrostatic potential of the flipped base to distinguish between O(6)-alkylguanine and guanine => ECO:0000269|PubMed:23112169 |
| Chain | Residue | Details |
| A | ARG69 |
