4EME
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043171 | biological_process | peptide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0043171 | biological_process | peptide catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0043171 | biological_process | peptide catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS87 |
| A | ASP325 |
| A | GLU380 |
| A | ASP435 |
| A | ZN1002 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1002 |
| Chain | Residue |
| A | ASP325 |
| A | GLU381 |
| A | HIS535 |
| A | ZN1001 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1001 |
| Chain | Residue |
| B | HIS87 |
| B | ASP325 |
| B | GLU380 |
| B | ASP435 |
| B | ZN1002 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1002 |
| Chain | Residue |
| B | ASP325 |
| B | GLU380 |
| B | GLU381 |
| B | HIS535 |
| B | ZN1001 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 1001 |
| Chain | Residue |
| C | HIS87 |
| C | ASP325 |
| C | GLU380 |
| C | ASP435 |
| C | ZN1002 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1002 |
| Chain | Residue |
| C | ASP325 |
| C | GLU381 |
| C | HIS535 |
| C | ZN1001 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 1001 |
| Chain | Residue |
| D | HIS87 |
| D | ASP325 |
| D | GLU380 |
| D | ASP435 |
| D | ZN1002 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1002 |
| Chain | Residue |
| D | ASP325 |
| D | GLU381 |
| D | HIS535 |
| D | ZN1001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22709581, ECO:0007744|PDB:4EME |
| Chain | Residue | Details |
| A | HIS87 | |
| B | HIS535 | |
| C | HIS87 | |
| C | ASP325 | |
| C | GLU381 | |
| C | ASP435 | |
| C | HIS535 | |
| D | HIS87 | |
| D | ASP325 | |
| D | GLU381 | |
| D | ASP435 | |
| A | ASP325 | |
| D | HIS535 | |
| A | GLU381 | |
| A | ASP435 | |
| A | HIS535 | |
| B | HIS87 | |
| B | ASP325 | |
| B | GLU381 | |
| B | ASP435 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9ULA0 |
| Chain | Residue | Details |
| A | HIS161 | |
| B | TYR470 | |
| C | HIS161 | |
| C | GLU380 | |
| C | HIS438 | |
| C | LYS463 | |
| C | TYR470 | |
| D | HIS161 | |
| D | GLU380 | |
| D | HIS438 | |
| D | LYS463 | |
| A | GLU380 | |
| D | TYR470 | |
| A | HIS438 | |
| A | LYS463 | |
| A | TYR470 | |
| B | HIS161 | |
| B | GLU380 | |
| B | HIS438 | |
| B | LYS463 |
