4EL9

Structure of N-terminal kinase domain of RSK2 with afzelin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AFE A 400

Chain	Residue
A	ILE50
A	LEU214
A	HOH513
A	HOH639
A	HOH718
A	HOH750
A	HOH783
A	PHE79
A	LYS100
A	VAL131
A	LEU147
A	ASP148
A	LEU155
A	GLU197
A	LEU200

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGKVFlVkkisgsdarql.......YAMK

Chain	Residue	Details
A	LEU74-LYS100

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNILL

Chain	Residue	Details
A	ILE189-LEU201

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site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. VEVNHPFIVkL

Chain	Residue	Details
A	VAL123-LEU133

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PDPK1","evidences":[{"source":"PubMed","id":"10480933","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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