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4EKD

Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001501biological_processskeletal system development
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007207biological_processphospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007507biological_processheart development
A0008217biological_processregulation of blood pressure
A0009791biological_processpost-embryonic development
A0010543biological_processregulation of platelet activation
A0016020cellular_componentmembrane
A0016322biological_processneuron remodeling
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0021884biological_processforebrain neuron development
A0030234molecular_functionenzyme regulator activity
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0032024biological_processpositive regulation of insulin secretion
A0042711biological_processmaternal behavior
A0042733biological_processembryonic digit morphogenesis
A0044297cellular_componentcell body
A0045202cellular_componentsynapse
A0045634biological_processregulation of melanocyte differentiation
A0046872molecular_functionmetal ion binding
A0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
A0048066biological_processdevelopmental pigmentation
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0086100biological_processendothelin receptor signaling pathway
A0099105biological_procession channel modulating, G protein-coupled receptor signaling pathway
A1904888biological_processcranial skeletal system development
A1990806biological_processligand-gated ion channel signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP A 401
ChainResidue
AGLU49
AVAL182
ACYS183
AASN274
ALYS275
AASP277
ALEU278
ACYS330
AALA331
ATHR332
AALF402
ASER50
AMG407
AHOH502
AHOH503
AGLY51
ALYS52
ASER53
ATHR54
ASER156
ALEU180
AARG181

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ALF A 402
ChainResidue
AGLY48
AGLU49
ALYS52
ASER53
APRO185
ATHR186
AGLY208
AGLN209
AGDP401
AMG407
AHOH501
AHOH502
AHOH503

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CO A 403
ChainResidue
AHIS105
AHIS109
ACL404
ACL405

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 404
ChainResidue
AHIS109
ACO403
ACL405

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 405
ChainResidue
AHIS105
AHIS109
ACO403
ACL404

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CO A 406
ChainResidue
AASP319
AASP321
BLYS142

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 407
ChainResidue
ASER53
ATHR186
AGDP401
AALF402
AHOH502
AHOH503

site_idAC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MES B 301
ChainResidue
AGLU119
ALYS120
ALYS133
AASP165
BASP85
BTRP113
BLYS120
BGLN174
BTYR178

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:20966218, ECO:0007744|PDB:7SQ2
ChainResidueDetails
ASER50
ALYS275
AASP277
AALA331
AGLY51
ALYS52
ATHR54
ASER156
ALEU180
AARG181
ACYS183
AASN274

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:20966218, ECO:0007744|PDB:7SQ2
ChainResidueDetails
ASER53
ATHR186

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: 5-glutamyl histamine => ECO:0000269|PubMed:23022564
ChainResidueDetails
AGLN209

226707

PDB entries from 2024-10-30

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