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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4EIY

Crystal structure of the chimeric protein of A2aAR-BRIL in complex with ZM241385 at 1.8A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ZMA A 2401

Chain	Residue
A	LEU85
A	HOH2521
A	HOH2524
A	HOH2585
A	HOH2668
A	PHE168
A	GLU169
A	MET177
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	MET270

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 2402

Chain	Residue
A	ASP52
A	SER91
A	HOH2529
A	HOH2552
A	HOH2579

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CLR A 2403

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	CLR2405
A	OLC2424
A	OLC2427

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CLR A 2404

Chain	Residue
A	LEU247
A	PRO248
A	CYS262
A	SER263
A	OLA2409

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CLR A 2405

Chain	Residue
A	LEU187
A	CYS254
A	PHE255
A	PHE258
A	CLR2403
A	OLA2409
A	OLC2424
A	OLC2427
A	HOH2603

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLA A 2406

Chain	Residue
A	THR65
A	THR68
A	OLA2408
A	OLC2424
A	HOH2657

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA A 2407

Chain	Residue
A	HIS264

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 2408

Chain	Residue
A	ILE10
A	OLA2406
A	OLA2420

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLA A 2409

Chain	Residue
A	PHE255
A	CYS262
A	CLR2404
A	CLR2405
A	OLC2424

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 2410

Chain	Residue
A	ILE3
A	SER7
A	THR11
A	HOH2667

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 2411

Chain	Residue
A	PHE44
A	ALA97
A	HOH2671

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA A 2412

Chain	Residue
A	HOH2611

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 2413

Chain	Residue
A	LEU198
A	ARG199
A	LEU202

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 2415

Chain	Residue
A	LEU19
A	LEU22
A	TRP29
A	VAL307

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLA A 2416

Chain	Residue
A	GLY5
A	SER6
A	TYR271
A	VAL275
A	HOH2504

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OLA A 2417

Chain	Residue
A	LEU192

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLA A 2418

Chain	Residue
A	PHE133
A	MET140
A	OLC2425

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLA A 2419

Chain	Residue
A	TYR290
A	ARG291

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLA A 2420

Chain	Residue
A	OLA2408
A	HOH2605

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLA A 2421

Chain	Residue
A	TRP32
A	VAL229
A	LYS233
A	HOH2673

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 2422

Chain	Residue
A	TYR179
A	PHE258
A	OLC2423
A	OLC2425
A	OLC2427
A	HOH2600

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLC A 2423

Chain	Residue
A	OLC2422
A	OLC2427

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OLC A 2424

Chain	Residue
A	OLA2409
A	HOH2657
A	HOH2674
A	PRO61
A	THR65
A	PHE70
A	CLR2403
A	CLR2405
A	OLA2406

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 2425

Chain	Residue
A	MET140
A	LEU141
A	TYR179
A	ALA184
A	OLA2418
A	OLC2422

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLB A 2426

Chain	Residue
A	CYS28
A	VAL31
A	TRP32
A	ARG205

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLC A 2427

Chain	Residue
A	PHE258
A	CLR2403
A	CLR2405
A	OLC2422
A	OLC2423

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OLC A 2428

Chain	Residue
A	TYR43
A	VAL46
A	PHE83
A	TRP129

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG A 2430

Chain	Residue
A	ARG120

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	LEU235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	SER277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

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PDB entries from 2025-06-11

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