4EHI
An X-ray Crystal Structure of a putative Bifunctional Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003937 | molecular_function | IMP cyclohydrolase activity |
| A | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003937 | molecular_function | IMP cyclohydrolase activity |
| B | 0004643 | molecular_function | phosphoribosylaminoimidazolecarboxamide formyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE BTB A 601 |
| Chain | Residue |
| A | SER6 |
| A | GLY124 |
| A | MSE127 |
| A | SO4606 |
| A | HOH895 |
| A | VAL7 |
| A | SER8 |
| A | THR30 |
| A | ASP49 |
| A | ASN99 |
| A | TYR101 |
| A | ASP121 |
| A | ILE122 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | TYR210 |
| A | SER239 |
| A | ASN241 |
| A | ASN242 |
| A | GLU319 |
| B | SER77 |
| B | ASP78 |
| B | GLU79 |
| B | ARG506 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | ARG506 |
| B | TYR210 |
| B | ASN241 |
| B | HOH806 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | ASN411 |
| A | THR429 |
| A | SER430 |
| A | ARG431 |
| A | HOH959 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | ASN213 |
| A | PRO214 |
| A | HIS215 |
| A | HOH917 |
| B | HIS74 |
| B | VAL505 |
| B | ARG506 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | LYS10 |
| A | GLY31 |
| A | GLY32 |
| A | BTB601 |
| A | HOH745 |
| A | HOH934 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | LYS276 |
| A | HIS285 |
| A | ASN418 |
| A | HOH932 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 601 |
| Chain | Residue |
| A | LYS338 |
| A | ARG339 |
| B | ALA0 |
| B | HIS81 |
| B | HOH751 |
| B | HOH775 |
| B | HOH860 |
| B | HOH902 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 602 |
| Chain | Residue |
| B | LYS10 |
| B | GLY32 |
| B | HOH757 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | ASN411 |
| B | SER430 |
| B | ARG431 |
| B | PRO461 |
