4EHC

Crystal structure of the C-terminal domain of Rv0977 of Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS-16
A	HIS-14
A	ASP36
A	ASP189

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	PRO120
A	ASN121
A	TYR262
A	HOH438

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	GLY28
A	GLN51
A	ASN52
A	HOH539
A	HOH575
A	ASN26

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 304

Chain	Residue
A	SER97
A	SER98
A	GLY101
A	THR102
A	HOH510
A	HOH592

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	SER170
A	THR171
A	ILE267
A	EDO310
A	HOH450

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	GLY41
A	LEU42
A	SER91
A	HOH416
A	HOH475

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	HIS-18
A	HIS-17
A	HIS-15
A	LEU158
A	GLY244
A	EDO328
A	HOH537
A	HOH541

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 308

Chain	Residue
A	PHE48
A	LEU49
A	GLN51
A	PHE53
A	TYR75
A	HOH506
A	HOH556

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 309

Chain	Residue
A	ASN156
A	THR163
A	TYR259
A	HOH422

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 310

Chain	Residue
A	PRO10
A	ALA148
A	GLY149
A	ILE169
A	SER170
A	THR171
A	PRO185
A	EDO305
A	HOH501

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 311

Chain	Residue
A	GLN224
A	THR225
A	LEU226
A	HOH562
A	HOH563
A	HOH564
A	HOH606

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 312

Chain	Residue
A	GLN12
A	PHE22
A	PRO32
A	SER110
A	HOH443

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 313

Chain	Residue
A	SER-12
A	GLU18
A	ARG109
A	ILE193
A	EDO327
A	HOH417
A	HOH523
A	HOH525

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 314

Chain	Residue
A	SER206
A	GLY207
A	GLN224
A	PHE239

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 315

Chain	Residue
A	SER-11
A	GLY-10
A	MSE30
A	PHE209
A	HOH421
A	HOH515

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 316

Chain	Residue
A	GLY111
A	ALA212
A	HOH407
A	HOH443
A	HOH522

---

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 317

Chain	Residue
A	PRO257
A	TYR259
A	LEU143
A	ASN156
A	GLY160
A	GLY161
A	ILE162
A	THR163

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 318

Chain	Residue
A	ILE57
A	SER76
A	PRO89
A	THR90
A	SER91
A	HOH504

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 319

Chain	Residue
A	GLY63
A	TYR64
A	LEU68
A	HOH583

---

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 320

Chain	Residue
A	THR17
A	THR50
A	ASN194
A	THR235
A	ASN236
A	HIS250
A	HOH589
A	HOH600

---

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 321

Chain	Residue
A	ALA7
A	THR8
A	PRO198
A	ALA200
A	LEU201
A	GLY243
A	GLY244
A	EDO322
A	HOH535

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 322

Chain	Residue
A	THR8
A	GLY82
A	ASN83
A	ALA200
A	EDO321
A	HOH452
A	HOH595

---

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 323

Chain	Residue
A	GLN29
A	PHE209
A	VAL210
A	PRO211
A	ALA212
A	HOH415
A	HOH465
A	HOH547

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 324

Chain	Residue
A	HIS-15
A	HIS-14
A	HIS-13

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 325

Chain	Residue
A	GLY161
A	LEU227
A	GLN256
A	THR271

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 326

Chain	Residue
A	LEU204
A	PRO205
A	GLY208
A	PHE209
A	PRO211
A	EDO331

---

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 327

Chain	Residue
A	HIS-14
A	PHE106
A	EDO313
A	HOH523
A	HOH525

---

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 328

Chain	Residue
A	HIS-18
A	HIS-15
A	HIS-16
A	SER-19
A	GLY66
A	EDO307
A	HOH583

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 329

Chain	Residue
A	PHE124
A	PRO125
A	GLY126
A	THR127

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 330

Chain	Residue
A	ASN15
A	SER108
A	ARG109
A	HOH512
A	HOH594

---

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 331

Chain	Residue
A	PRO205
A	SER206
A	GLY207
A	GLY208
A	ASP222
A	GLN224
A	EDO326

---

site_id	DC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 332

Chain	Residue
A	PRO10
A	PHE22
A	MSE30
A	PHE81
A	GLN183
A	HOH406
A	HOH492
A	HOH595

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23923105, ECO:0007744|PDB:4EHC

Chain	Residue	Details
A	ASP36
A	ASP189

---