4EG2
2.2 Angstrom Crystal Structure of Cytidine deaminase from Vibrio cholerae in Complex with Zinc and Uridine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004126 | molecular_function | cytidine deaminase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009972 | biological_process | cytidine deamination |
A | 0016787 | molecular_function | hydrolase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004126 | molecular_function | cytidine deaminase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009972 | biological_process | cytidine deamination |
B | 0016787 | molecular_function | hydrolase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004126 | molecular_function | cytidine deaminase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0008270 | molecular_function | zinc ion binding |
C | 0009972 | biological_process | cytidine deamination |
C | 0016787 | molecular_function | hydrolase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0004126 | molecular_function | cytidine deaminase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0008270 | molecular_function | zinc ion binding |
D | 0009972 | biological_process | cytidine deamination |
D | 0016787 | molecular_function | hydrolase activity |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0004126 | molecular_function | cytidine deaminase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0008270 | molecular_function | zinc ion binding |
E | 0009972 | biological_process | cytidine deamination |
E | 0016787 | molecular_function | hydrolase activity |
E | 0042802 | molecular_function | identical protein binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0004126 | molecular_function | cytidine deaminase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0008270 | molecular_function | zinc ion binding |
F | 0009972 | biological_process | cytidine deamination |
F | 0016787 | molecular_function | hydrolase activity |
F | 0042802 | molecular_function | identical protein binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
G | 0003824 | molecular_function | catalytic activity |
G | 0004126 | molecular_function | cytidine deaminase activity |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0008270 | molecular_function | zinc ion binding |
G | 0009972 | biological_process | cytidine deamination |
G | 0016787 | molecular_function | hydrolase activity |
G | 0042802 | molecular_function | identical protein binding |
G | 0046872 | molecular_function | metal ion binding |
G | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
H | 0003824 | molecular_function | catalytic activity |
H | 0004126 | molecular_function | cytidine deaminase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0008270 | molecular_function | zinc ion binding |
H | 0009972 | biological_process | cytidine deamination |
H | 0016787 | molecular_function | hydrolase activity |
H | 0042802 | molecular_function | identical protein binding |
H | 0046872 | molecular_function | metal ion binding |
H | 0047844 | molecular_function | obsolete deoxycytidine deaminase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 301 |
Chain | Residue |
A | HIS102 |
A | CYS129 |
A | CYS132 |
A | URI302 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE URI A 302 |
Chain | Residue |
A | VAL101 |
A | HIS102 |
A | ALA103 |
A | GLU104 |
A | PRO128 |
A | CYS129 |
A | ZN301 |
A | HOH514 |
B | ALA232 |
A | PHE71 |
A | VAL73 |
A | ASN89 |
A | GLU91 |
A | THR100 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT A 303 |
Chain | Residue |
A | GLU253 |
A | PHE255 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 301 |
Chain | Residue |
B | HOH499 |
B | HOH604 |
B | HOH605 |
E | HOH551 |
E | HOH552 |
F | HOH559 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 302 |
Chain | Residue |
B | HIS102 |
B | CYS129 |
B | CYS132 |
B | URI303 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE URI B 303 |
Chain | Residue |
A | ALA232 |
A | ALA233 |
B | PHE71 |
B | VAL73 |
B | ASN89 |
B | GLU91 |
B | THR100 |
B | VAL101 |
B | HIS102 |
B | ALA103 |
B | GLU104 |
B | PRO128 |
B | CYS129 |
B | ZN302 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT B 304 |
Chain | Residue |
B | TYR65 |
B | GLU253 |
B | PHE255 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 301 |
Chain | Residue |
C | HIS102 |
C | CYS129 |
C | CYS132 |
C | URI302 |
site_id | AC9 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE URI C 302 |
Chain | Residue |
C | PHE71 |
C | ASN89 |
C | GLU91 |
C | THR100 |
C | VAL101 |
C | HIS102 |
C | ALA103 |
C | GLU104 |
C | PRO128 |
C | CYS129 |
C | ZN301 |
D | ALA232 |
D | ALA233 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 301 |
Chain | Residue |
D | HIS102 |
D | CYS129 |
D | CYS132 |
D | URI302 |
site_id | BC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE URI D 302 |
Chain | Residue |
C | PHE165 |
C | ALA232 |
C | ALA233 |
C | PHE234 |
D | PHE71 |
D | VAL73 |
D | ASN89 |
D | GLU91 |
D | THR100 |
D | VAL101 |
D | HIS102 |
D | ALA103 |
D | GLU104 |
D | PRO128 |
D | CYS129 |
D | ZN301 |
site_id | BC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT D 303 |
Chain | Residue |
B | ARG198 |
D | GLN40 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT D 304 |
Chain | Residue |
D | TYR65 |
D | GLU253 |
D | PHE255 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 301 |
Chain | Residue |
E | HIS102 |
E | CYS129 |
E | CYS132 |
E | URI302 |
site_id | BC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE URI E 302 |
Chain | Residue |
E | ALA103 |
E | GLU104 |
E | PRO128 |
E | CYS129 |
E | ZN301 |
F | ALA232 |
F | ALA233 |
F | PHE234 |
E | PHE71 |
E | VAL73 |
E | ASN89 |
E | GLU91 |
E | THR100 |
E | HIS102 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT E 303 |
Chain | Residue |
E | GLU253 |
E | PHE255 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT E 304 |
Chain | Residue |
E | ARG4 |
E | ALA66 |
E | GLU70 |
E | TYR72 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT E 305 |
Chain | Residue |
E | ASP51 |
E | LYS151 |
E | ARG152 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 301 |
Chain | Residue |
F | HIS102 |
F | CYS129 |
F | CYS132 |
F | URI302 |
site_id | CC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE URI F 302 |
Chain | Residue |
E | ALA232 |
E | ALA233 |
F | PHE71 |
F | VAL73 |
F | ASN89 |
F | GLU91 |
F | THR100 |
F | VAL101 |
F | HIS102 |
F | ALA103 |
F | GLU104 |
F | PRO128 |
F | CYS129 |
F | ZN301 |
site_id | CC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT F 303 |
Chain | Residue |
F | TYR65 |
F | GLU253 |
F | PHE255 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN G 301 |
Chain | Residue |
G | HIS102 |
G | CYS129 |
G | CYS132 |
G | URI302 |
site_id | CC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE URI G 302 |
Chain | Residue |
G | PHE71 |
G | VAL73 |
G | ASN89 |
G | GLU91 |
G | THR100 |
G | VAL101 |
G | HIS102 |
G | ALA103 |
G | GLU104 |
G | SER127 |
G | PRO128 |
G | CYS129 |
G | ZN301 |
H | ALA232 |
H | ALA233 |
H | PHE234 |
site_id | CC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT G 303 |
Chain | Residue |
G | GLU253 |
G | PHE255 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN H 301 |
Chain | Residue |
H | HIS102 |
H | CYS129 |
H | CYS132 |
H | URI302 |
site_id | CC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE URI H 302 |
Chain | Residue |
G | ALA232 |
G | PHE234 |
H | ASN89 |
H | GLU91 |
H | THR100 |
H | VAL101 |
H | HIS102 |
H | ALA103 |
H | GLU104 |
H | PRO128 |
H | CYS129 |
H | ZN301 |
Functional Information from PROSITE/UniProt
site_id | PS00903 |
Number of Residues | 35 |
Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEqcAIshawmkgekgvaditinfs..............PCgh......CrqfM |
Chain | Residue | Details |
A | HIS102-MSE136 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01558 |
Chain | Residue | Details |
A | GLU104 | |
B | GLU104 | |
C | GLU104 | |
D | GLU104 | |
E | GLU104 | |
F | GLU104 | |
G | GLU104 | |
H | GLU104 |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01558 |
Chain | Residue | Details |
G | ASN89 | |
G | HIS102 | |
G | CYS129 | |
G | CYS132 | |
H | ASN89 | |
H | HIS102 | |
H | CYS129 | |
H | CYS132 | |
E | CYS129 | |
E | CYS132 | |
F | ASN89 | |
F | HIS102 | |
F | CYS129 | |
F | CYS132 | |
A | ASN89 | |
A | HIS102 | |
A | CYS129 | |
A | CYS132 | |
B | ASN89 | |
B | HIS102 | |
B | CYS129 | |
B | CYS132 | |
C | ASN89 | |
C | HIS102 | |
C | CYS129 | |
C | CYS132 | |
D | ASN89 | |
D | HIS102 | |
D | CYS129 | |
D | CYS132 | |
E | ASN89 | |
E | HIS102 |