4EDH
The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with ADP,TMP and Mg.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE TMP A 301 |
| Chain | Residue |
| A | GLU39 |
| A | GLN105 |
| A | PHE155 |
| A | HOH422 |
| A | HOH440 |
| A | HOH441 |
| A | HOH472 |
| A | HOH600 |
| A | HOH601 |
| A | PRO40 |
| A | ARG50 |
| A | MET70 |
| A | ARG74 |
| A | ARG96 |
| A | ALA100 |
| A | THR101 |
| A | TYR104 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP A 302 |
| Chain | Residue |
| A | GLY13 |
| A | ALA14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | THR18 |
| A | ARG145 |
| A | ALA186 |
| A | LEU188 |
| A | PRO189 |
| A | LEU190 |
| A | VAL193 |
| A | MG303 |
| A | HOH408 |
| A | HOH475 |
| A | HOH532 |
| A | HOH536 |
| A | HOH552 |
| A | HOH576 |
| A | HOH600 |
| A | HOH603 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 303 |
| Chain | Residue |
| A | SER17 |
| A | ADP302 |
| A | HOH472 |
| A | HOH599 |
| A | HOH600 |
| A | HOH603 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TRS A 304 |
| Chain | Residue |
| A | ASP185 |
| A | GLY187 |
| A | HOH442 |
| A | HOH526 |
| B | PRO138 |
| B | ILE141 |
| B | ASP185 |
| B | GLY187 |
| B | HOH431 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 305 |
| Chain | Residue |
| A | ARG128 |
| A | ARG180 |
| A | HOH594 |
| A | HOH598 |
| B | EDO304 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE TMP B 301 |
| Chain | Residue |
| B | GLU12 |
| B | GLU39 |
| B | PRO40 |
| B | ARG50 |
| B | MET70 |
| B | ARG74 |
| B | ARG96 |
| B | ALA100 |
| B | THR101 |
| B | TYR104 |
| B | GLN105 |
| B | PHE155 |
| B | HOH414 |
| B | HOH415 |
| B | HOH416 |
| B | HOH536 |
| B | HOH621 |
| B | HOH622 |
| B | HOH623 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP B 302 |
| Chain | Residue |
| A | ASP126 |
| A | HOH515 |
| B | GLY13 |
| B | ALA14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | THR18 |
| B | ARG145 |
| B | ALA186 |
| B | LEU188 |
| B | LEU190 |
| B | MG303 |
| B | HOH430 |
| B | HOH434 |
| B | HOH481 |
| B | HOH490 |
| B | HOH578 |
| B | HOH583 |
| B | HOH621 |
| B | HOH624 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | ADP302 |
| B | HOH621 |
| B | HOH622 |
| B | HOH623 |
| B | HOH624 |
| B | SER17 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| A | ALA177 |
| A | GLU179 |
| A | SO4305 |
| B | ARG38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY10 | |
| B | GLY10 |
