4E4L

JAK1 kinase (JH1 domain) in complex with compound 30

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0NH A 1201

Chain	Residue
A	GLY882
A	ASN1008
A	LEU1010
A	GLY1020
A	ASP1021
A	HOH1308
A	HOH1383
A	HOH1399
A	GLU883
A	VAL889
A	ALA906
A	MET956
A	GLU957
A	PHE958
A	LEU959
A	ARG1007

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 0NH A 1202

Chain	Residue
A	HOH1441
A	HOH1442
E	LEU881
E	GLY882
E	GLU883
E	VAL889
E	ALA906
E	GLU957
E	PHE958
E	LEU959
E	ARG1007
E	ASN1008
E	LEU1010
E	GLY1020
E	ASP1021

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 0NH B 1201

Chain	Residue
B	LEU881
B	GLY882
B	GLU883
B	VAL889
B	ALA906
B	GLU957
B	PHE958
B	LEU959
B	ARG1007
B	ASN1008
B	LEU1010
B	GLY1020
B	ASP1021
B	HOH1338
B	HOH1343

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0NH D 1201

Chain	Residue
D	GLY882
D	GLU883
D	VAL889
D	ALA906
D	GLU957
D	PHE958
D	LEU959
D	ARG1007
D	ASN1008
D	LEU1010
D	GLY1020
D	ASP1021
D	HOH1320
D	HOH1383

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGHFGKVElCrydpegdntgeq......VAVK

Chain	Residue	Details
A	LEU881-LYS908

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNVLV

Chain	Residue	Details
A	TYR999-VAL1011

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP1003
B	ASP1003
E	ASP1003
D	ASP1003

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU881
B	LEU881
E	LEU881
D	LEU881

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333

Chain	Residue	Details
A	LYS908
B	LYS908
E	LYS908
D	LYS908

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529

Chain	Residue	Details
A	PTR1034
A	PTR1035
B	PTR1034
B	PTR1035
E	PTR1034
E	PTR1035
D	PTR1034
D	PTR1035

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