4E1O
Human histidine decarboxylase complex with Histidine methyl ester (HME)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0016830 | molecular_function | carbon-carbon lyase activity |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0016830 | molecular_function | carbon-carbon lyase activity |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0016830 | molecular_function | carbon-carbon lyase activity |
C | 0016831 | molecular_function | carboxy-lyase activity |
C | 0019752 | biological_process | carboxylic acid metabolic process |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0006520 | biological_process | amino acid metabolic process |
D | 0016830 | molecular_function | carbon-carbon lyase activity |
D | 0016831 | molecular_function | carboxy-lyase activity |
D | 0019752 | biological_process | carboxylic acid metabolic process |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
E | 0006520 | biological_process | amino acid metabolic process |
E | 0016830 | molecular_function | carbon-carbon lyase activity |
E | 0016831 | molecular_function | carboxy-lyase activity |
E | 0019752 | biological_process | carboxylic acid metabolic process |
E | 0030170 | molecular_function | pyridoxal phosphate binding |
F | 0006520 | biological_process | amino acid metabolic process |
F | 0016830 | molecular_function | carbon-carbon lyase activity |
F | 0016831 | molecular_function | carboxy-lyase activity |
F | 0019752 | biological_process | carboxylic acid metabolic process |
F | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP A 1000 |
Chain | Residue |
A | TYR81 |
A | ASN302 |
A | LYS305 |
A | PVH1001 |
A | HOH1141 |
B | LEU353 |
B | SER354 |
A | THR149 |
A | VAL150 |
A | SER151 |
A | HIS194 |
A | GLY246 |
A | THR248 |
A | ASP273 |
A | ALA275 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE PVH A 1001 |
Chain | Residue |
A | TYR80 |
A | TYR81 |
A | PRO82 |
A | HIS194 |
A | LYS305 |
A | PLP1000 |
A | HOH1110 |
B | LEU102 |
B | TYR334 |
B | LEU353 |
B | SER354 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP B 1000 |
Chain | Residue |
A | LEU353 |
A | SER354 |
B | TYR81 |
B | THR149 |
B | VAL150 |
B | SER151 |
B | HIS194 |
B | GLY246 |
B | THR248 |
B | ASP273 |
B | ALA275 |
B | ASN302 |
B | LYS305 |
B | PVH1001 |
B | HOH1180 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PVH B 1001 |
Chain | Residue |
A | LEU102 |
A | TYR334 |
A | SER354 |
B | TYR80 |
B | TYR81 |
B | PRO82 |
B | HIS194 |
B | THR248 |
B | LYS305 |
B | ILE436 |
B | PLP1000 |
B | HOH1112 |
site_id | AC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP C 1000 |
Chain | Residue |
C | TYR81 |
C | THR149 |
C | VAL150 |
C | SER151 |
C | HIS194 |
C | GLY246 |
C | THR248 |
C | ASP273 |
C | ALA275 |
C | ASN302 |
C | LYS305 |
C | PVH1001 |
C | HOH1166 |
D | LEU353 |
D | SER354 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PVH C 1001 |
Chain | Residue |
C | TYR80 |
C | TYR81 |
C | PRO82 |
C | HIS194 |
C | THR248 |
C | LYS305 |
C | PLP1000 |
C | HOH1110 |
D | LEU102 |
D | TYR334 |
D | LEU335 |
D | SER354 |
site_id | AC7 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP D 1000 |
Chain | Residue |
C | LEU353 |
C | SER354 |
D | TYR81 |
D | THR149 |
D | VAL150 |
D | SER151 |
D | HIS194 |
D | GLY246 |
D | THR248 |
D | ASP273 |
D | ALA275 |
D | ASN302 |
D | LYS305 |
D | PVH1001 |
D | HOH1178 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PVH D 1001 |
Chain | Residue |
D | TYR80 |
D | TYR81 |
D | PRO82 |
D | HIS194 |
D | THR248 |
D | LYS305 |
D | ILE436 |
D | PLP1000 |
D | HOH1121 |
C | LEU102 |
C | TYR334 |
C | LEU335 |
C | SER354 |
site_id | AC9 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP E 1000 |
Chain | Residue |
E | TYR81 |
E | THR149 |
E | VAL150 |
E | SER151 |
E | HIS194 |
E | GLY246 |
E | THR248 |
E | ASP273 |
E | ALA275 |
E | ASN302 |
E | LYS305 |
E | PVH1001 |
F | LEU353 |
F | SER354 |
F | HOH1109 |
site_id | BC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PVH E 1001 |
Chain | Residue |
E | TYR80 |
E | TYR81 |
E | PRO82 |
E | HIS194 |
E | THR248 |
E | LYS305 |
E | ILE436 |
E | PLP1000 |
E | HOH1106 |
F | LEU102 |
F | TYR334 |
F | LEU353 |
F | SER354 |
site_id | BC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP F 1000 |
Chain | Residue |
E | LEU353 |
E | SER354 |
F | TYR81 |
F | THR149 |
F | VAL150 |
F | SER151 |
F | HIS194 |
F | GLY246 |
F | THR248 |
F | ASP273 |
F | ALA275 |
F | ASN302 |
F | LYS305 |
F | PVH1001 |
F | HOH1123 |
site_id | BC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PVH F 1001 |
Chain | Residue |
E | LEU102 |
E | TYR334 |
E | LEU353 |
E | SER354 |
F | TYR80 |
F | TYR81 |
F | PRO82 |
F | HIS194 |
F | THR248 |
F | LYS305 |
F | PLP1000 |
F | HOH1103 |
Functional Information from PROSITE/UniProt
site_id | PS00392 |
Number of Residues | 22 |
Details | DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFtFnpsKWMmVhFDCtgFWvK |
Chain | Residue | Details |
A | SER298-LYS319 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: |
Chain | Residue | Details |
D | TYR81 | |
D | HIS194 | |
E | TYR81 | |
E | HIS194 | |
F | TYR81 | |
F | HIS194 | |
A | TYR81 | |
A | HIS194 | |
B | TYR81 | |
B | HIS194 | |
C | TYR81 | |
C | HIS194 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
Chain | Residue | Details |
A | LYS305 | |
B | LYS305 | |
C | LYS305 | |
D | LYS305 | |
E | LYS305 | |
F | LYS305 |