4E1O
Human histidine decarboxylase complex with Histidine methyl ester (HME)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016830 | molecular_function | carbon-carbon lyase activity |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016830 | molecular_function | carbon-carbon lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016830 | molecular_function | carbon-carbon lyase activity |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0030170 | molecular_function | pyridoxal phosphate binding |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016830 | molecular_function | carbon-carbon lyase activity |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019752 | biological_process | carboxylic acid metabolic process |
| F | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 1000 |
| Chain | Residue |
| A | TYR81 |
| A | ASN302 |
| A | LYS305 |
| A | PVH1001 |
| A | HOH1141 |
| B | LEU353 |
| B | SER354 |
| A | THR149 |
| A | VAL150 |
| A | SER151 |
| A | HIS194 |
| A | GLY246 |
| A | THR248 |
| A | ASP273 |
| A | ALA275 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PVH A 1001 |
| Chain | Residue |
| A | TYR80 |
| A | TYR81 |
| A | PRO82 |
| A | HIS194 |
| A | LYS305 |
| A | PLP1000 |
| A | HOH1110 |
| B | LEU102 |
| B | TYR334 |
| B | LEU353 |
| B | SER354 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP B 1000 |
| Chain | Residue |
| A | LEU353 |
| A | SER354 |
| B | TYR81 |
| B | THR149 |
| B | VAL150 |
| B | SER151 |
| B | HIS194 |
| B | GLY246 |
| B | THR248 |
| B | ASP273 |
| B | ALA275 |
| B | ASN302 |
| B | LYS305 |
| B | PVH1001 |
| B | HOH1180 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PVH B 1001 |
| Chain | Residue |
| A | LEU102 |
| A | TYR334 |
| A | SER354 |
| B | TYR80 |
| B | TYR81 |
| B | PRO82 |
| B | HIS194 |
| B | THR248 |
| B | LYS305 |
| B | ILE436 |
| B | PLP1000 |
| B | HOH1112 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP C 1000 |
| Chain | Residue |
| C | TYR81 |
| C | THR149 |
| C | VAL150 |
| C | SER151 |
| C | HIS194 |
| C | GLY246 |
| C | THR248 |
| C | ASP273 |
| C | ALA275 |
| C | ASN302 |
| C | LYS305 |
| C | PVH1001 |
| C | HOH1166 |
| D | LEU353 |
| D | SER354 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PVH C 1001 |
| Chain | Residue |
| C | TYR80 |
| C | TYR81 |
| C | PRO82 |
| C | HIS194 |
| C | THR248 |
| C | LYS305 |
| C | PLP1000 |
| C | HOH1110 |
| D | LEU102 |
| D | TYR334 |
| D | LEU335 |
| D | SER354 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP D 1000 |
| Chain | Residue |
| C | LEU353 |
| C | SER354 |
| D | TYR81 |
| D | THR149 |
| D | VAL150 |
| D | SER151 |
| D | HIS194 |
| D | GLY246 |
| D | THR248 |
| D | ASP273 |
| D | ALA275 |
| D | ASN302 |
| D | LYS305 |
| D | PVH1001 |
| D | HOH1178 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PVH D 1001 |
| Chain | Residue |
| D | TYR80 |
| D | TYR81 |
| D | PRO82 |
| D | HIS194 |
| D | THR248 |
| D | LYS305 |
| D | ILE436 |
| D | PLP1000 |
| D | HOH1121 |
| C | LEU102 |
| C | TYR334 |
| C | LEU335 |
| C | SER354 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP E 1000 |
| Chain | Residue |
| E | TYR81 |
| E | THR149 |
| E | VAL150 |
| E | SER151 |
| E | HIS194 |
| E | GLY246 |
| E | THR248 |
| E | ASP273 |
| E | ALA275 |
| E | ASN302 |
| E | LYS305 |
| E | PVH1001 |
| F | LEU353 |
| F | SER354 |
| F | HOH1109 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PVH E 1001 |
| Chain | Residue |
| E | TYR80 |
| E | TYR81 |
| E | PRO82 |
| E | HIS194 |
| E | THR248 |
| E | LYS305 |
| E | ILE436 |
| E | PLP1000 |
| E | HOH1106 |
| F | LEU102 |
| F | TYR334 |
| F | LEU353 |
| F | SER354 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP F 1000 |
| Chain | Residue |
| E | LEU353 |
| E | SER354 |
| F | TYR81 |
| F | THR149 |
| F | VAL150 |
| F | SER151 |
| F | HIS194 |
| F | GLY246 |
| F | THR248 |
| F | ASP273 |
| F | ALA275 |
| F | ASN302 |
| F | LYS305 |
| F | PVH1001 |
| F | HOH1123 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PVH F 1001 |
| Chain | Residue |
| E | LEU102 |
| E | TYR334 |
| E | LEU353 |
| E | SER354 |
| F | TYR80 |
| F | TYR81 |
| F | PRO82 |
| F | HIS194 |
| F | THR248 |
| F | LYS305 |
| F | PLP1000 |
| F | HOH1103 |
Functional Information from PROSITE/UniProt
| site_id | PS00392 |
| Number of Residues | 22 |
| Details | DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFtFnpsKWMmVhFDCtgFWvK |
| Chain | Residue | Details |
| A | SER298-LYS319 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
