4DXJ
Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-propylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| C | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASP98 |
| A | ASP102 |
| A | MG402 |
| A | 0M9404 |
| A | HOH506 |
| A | HOH507 |
| A | HOH508 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | MG401 |
| A | 0M9404 |
| A | HOH504 |
| A | HOH505 |
| A | ASP98 |
| A | ASP102 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 403 |
| Chain | Residue |
| A | ASP250 |
| A | 0M9404 |
| A | HOH501 |
| A | HOH502 |
| A | HOH503 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 0M9 A 404 |
| Chain | Residue |
| A | ASP98 |
| A | ASP102 |
| A | ARG107 |
| A | GLN167 |
| A | LYS207 |
| A | TYR211 |
| A | GLN247 |
| A | ASP250 |
| A | LYS264 |
| A | MG401 |
| A | MG402 |
| A | MG403 |
| A | IPE405 |
| A | HOH501 |
| A | HOH502 |
| A | HOH503 |
| A | HOH504 |
| A | HOH505 |
| A | HOH507 |
| A | HOH508 |
| A | HOH510 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IPE A 405 |
| Chain | Residue |
| A | GLY47 |
| A | LYS48 |
| A | ARG51 |
| A | GLN91 |
| A | ARG108 |
| A | TYR211 |
| A | PHE246 |
| A | GLN247 |
| A | LYS362 |
| A | 0M9404 |
| A | HOH512 |
| A | HOH513 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG A 406 |
| Chain | Residue |
| A | THR42 |
| A | THR43 |
| A | LEU95 |
| A | VAL96 |
| A | ASP99 |
| A | ARG107 |
| A | CYS112 |
| A | TRP113 |
| A | TYR114 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 407 |
| Chain | Residue |
| A | PHE17 |
| A | GLN21 |
| A | HIS141 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | ASP98 |
| B | ASP102 |
| B | ASP170 |
| B | MG402 |
| B | 0M9404 |
| B | HOH556 |
| B | HOH557 |
| B | HOH558 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | ASP98 |
| B | ASP102 |
| B | MG401 |
| B | 0M9404 |
| B | HOH554 |
| B | HOH555 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 403 |
| Chain | Residue |
| B | ASP250 |
| B | 0M9404 |
| B | HOH551 |
| B | HOH552 |
| B | HOH553 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 0M9 B 404 |
| Chain | Residue |
| B | HOH555 |
| B | HOH557 |
| B | HOH558 |
| B | HOH559 |
| B | ASP98 |
| B | ASP102 |
| B | ARG107 |
| B | GLN167 |
| B | LYS207 |
| B | TYR211 |
| B | ASP250 |
| B | LYS264 |
| B | MG401 |
| B | MG402 |
| B | MG403 |
| B | IPE405 |
| B | HOH501 |
| B | HOH551 |
| B | HOH552 |
| B | HOH553 |
| B | HOH554 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE IPE B 405 |
| Chain | Residue |
| B | GLY47 |
| B | LYS48 |
| B | ARG51 |
| B | GLN91 |
| B | ARG108 |
| B | TYR211 |
| B | PHE246 |
| B | GLN247 |
| B | ASP250 |
| B | LYS264 |
| B | 0M9404 |
| B | HOH503 |
| B | HOH505 |
| B | HOH538 |
| B | HOH561 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG B 406 |
| Chain | Residue |
| B | THR43 |
| B | ALA92 |
| B | LEU95 |
| B | VAL96 |
| B | ASP99 |
| B | TRP113 |
| B | TYR114 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 407 |
| Chain | Residue |
| B | GLU13 |
| B | HIS78 |
| B | HIS141 |
| B | TYR142 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 408 |
| Chain | Residue |
| A | LYS158 |
| B | PHE17 |
| B | HIS141 |
| B | HOH546 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE B 409 |
| Chain | Residue |
| A | ILE129 |
| A | LYS132 |
| A | SER133 |
| A | ASP160 |
| B | ILE129 |
| B | LYS132 |
| B | SER133 |
| B | ASP160 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG C 401 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | ASP170 |
| C | MG402 |
| C | 0M9404 |
| C | HOH538 |
| C | HOH539 |
| C | HOH540 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 402 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | MG401 |
| C | 0M9404 |
| C | HOH536 |
| C | HOH537 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 403 |
| Chain | Residue |
| C | ASP250 |
| C | 0M9404 |
| C | HOH533 |
| C | HOH534 |
| C | HOH535 |
| site_id | CC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 0M9 C 404 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | ARG107 |
| C | GLN167 |
| C | LYS207 |
| C | TYR211 |
| C | ASP250 |
| C | LYS264 |
| C | MG401 |
| C | MG402 |
| C | MG403 |
| C | IPE405 |
| C | HOH535 |
| C | HOH536 |
| C | HOH537 |
| C | HOH539 |
| C | HOH540 |
| C | HOH542 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE IPE C 405 |
| Chain | Residue |
| C | GLY47 |
| C | LYS48 |
| C | ARG51 |
| C | GLN91 |
| C | ARG108 |
| C | TYR211 |
| C | PHE246 |
| C | GLN247 |
| C | ASP250 |
| C | LYS362 |
| C | 0M9404 |
| C | HOH505 |
| C | HOH543 |
| C | HOH544 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 406 |
| Chain | Residue |
| C | LYS25 |
| C | HIS141 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG C 407 |
| Chain | Residue |
| C | LEU214 |
| C | MET232 |
| C | GLU236 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C 408 |
| Chain | Residue |
| C | LEU8 |
| C | ASP12 |
Functional Information from PROSITE/UniProt
