4DXA
Co-crystal structure of Rap1 in complex with KRIT1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017156 | biological_process | calcium-ion regulated exocytosis |
| A | 0019003 | molecular_function | GDP binding |
| A | 0032486 | biological_process | Rap protein signal transduction |
| A | 0033625 | biological_process | positive regulation of integrin activation |
| A | 0035577 | cellular_component | azurophil granule membrane |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045955 | biological_process | negative regulation of calcium ion-dependent exocytosis |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0061028 | biological_process | establishment of endothelial barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070161 | cellular_component | anchoring junction |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0071320 | biological_process | cellular response to cAMP |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099010 | biological_process | modification of postsynaptic structure |
| A | 1901888 | biological_process | regulation of cell junction assembly |
| A | 2000114 | biological_process | regulation of establishment of cell polarity |
| A | 2000301 | biological_process | negative regulation of synaptic vesicle exocytosis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GSP A 201 |
| Chain | Residue |
| A | VAL12 |
| A | GLU30 |
| A | TYR32 |
| A | THR35 |
| A | GLY60 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER147 |
| A | ALA148 |
| A | GLY13 |
| A | LYS149 |
| A | MG202 |
| A | HOH316 |
| A | HOH354 |
| A | HOH374 |
| A | HOH382 |
| A | HOH386 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GSP201 |
| A | HOH381 |
| A | HOH382 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Region: {"description":"Interaction with KRIT1","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18309292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylserine; by botulinum toxin","evidences":[{"source":"PubMed","id":"3141412","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Region: {"description":"Interaction with RAP1B","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
